Results 151 to 160 of about 457,473 (371)

Overexpression of Na+/Mg2+ exchanger SLC41A1 attenuates pro-survival signaling [PDF]

, 2017
The Na+/Mg2+ exchanger SLC41A1 (A1), a key component of intracellular Mg homeostasis (IMH), is the major cellular Mg2+ efflux system, and its overexpression decreases [Mg2+]intracellular.
Abdulhanan, Nasrin, Aschenbach, Jörg R., Cibulka, Michal, Fröhlich, Nadine, Kolisek, Martin, Mastrototaro, Lucia, Pilchova, Ivana, Racay, Peter, Röntgen, Monika, Sponder, Gerhard   +9 more
core   +1 more source

Profile of pacritinib and its potential in the treatment of hematologic disorders

Journal of Blood Medicine, 2014
Eleftheria Hatzimichael, Evangelos Tsolas, Evangelos Briasoulis Department of Haematology, University Hospital of Ioannina, Ioannina, Greece Abstract: Pacritinib (previously known as SB-1518) is an innovative selective inhibitor of Janus kinase 2 and ...
Hatzimichael E, Tsolas E, Briasoulis E
doaj  

Role of Janus kinase-2 in insulin-mediated phosphorylation and inactivation of protein phosphatase-2A and its impact on upstream insulin signalling components [PDF]

, 1999
Najma BEGUM, Louis Ragolia
openalex   +1 more source

The Burden of Alopecia Areata and Management with Baricitinib in the United Arab Emirates: A Narrative Review

Dermatology and Therapy
Alopecia areata is an inflammatory autoimmune disease that presents as non-scarring hair loss in adults and children and causes substantial psychological distress, economic burden, and reduced quality of life for those affected.
Hussein Abdel Dayem, Anwar Al Hammadi, Ashraf Reda, Fatima Albreiki, Ayman Al Naeem, Ahmed Ameen, Mohamed Ahmed, Huda Rajab Ali, Mohamed Elrayes, Gozde Senay, Muna Al Murrawi   +10 more
doaj   +1 more source

Assessment of interleukin-10 level and Janus kinase 2 V617F mutation incidence in patients with primary myelofibrosis

Iraqi Journal of Hematology, 2016
Background: Myelofibrosis (MF) is largely documented by an abnormal cytokine expression, which in turn could contribute to bone marrow fibrosis, angiogenesis, and constitutional symptoms.
Shahla′a Fadhil Sabir
doaj   +1 more source

Detection of Exon 12 and 14 Mutations in Janus Kinase 2 Gene Including a Novel Mutant in V617F Negative Polycythemia Vera Patients from Pakistan [PDF]

, 2018
Afia Muhammad Akram, Humera Kausar, Asma Chaudhary, Ahmad Mukhtar Khalid, Muhammad Mudassar Shahzad, Muhammad Akhtar, Muhammad Farooq Sabar, Nadia Sajid, Nawaf Al Anazi, Aamir Aleem, Zafar Iqbal   +10 more
openalex   +1 more source

2-Methoxystypandrone inhibits signal transducer and activator of transcription 3 and nuclear factor-κB signaling by inhibiting Janus kinase 2 and IκB kinase

Cancer Science, 2014
Constitutive activation of the signal transducer and activator of transcription 3 (STAT3) or the nuclear factor‐κB (NF‐κB) pathway occurs frequently in cancer cells and contributes to oncogenesis.
Shan Kuang, Chunting Qi, Jiawei Liu, Xiaoxiao Sun, Qing Zhang, Zhenhua Sima, Jingli Liu, Wuguo Li, Qiang Z. Yu   +8 more
semanticscholar   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Clinical Manifestation of Calreticulin Gene Mutations in Essential Thrombocythemia without Janus Kinase 2 and MPL Mutations: A Chinese Cohort Clinical Study

Chinese Medical Journal, 2016
Background: Recently, calreticulin (CALR) gene mutations have been identified in patients with essential thrombocythemia (ET). A high-frequency of ET cases without Janus kinase 2 (JAK2) mutations contain CALR mutations and exhibit clinical ...
Chao Sun, Xin Zhou, Zhi-Jian Zou, Hong-Feng Guo, Jian-Yong Li, Chun Qiao   +5 more
doaj   +1 more source

α2,3‐Sialyltransferase (ST3Gal1) regulates endometrioid‐type epithelial ovarian cancer cell migration and invasion via VEGF‐R2/JAK2/STAT3 signaling cascades

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the role of ST3 β‐galactoside α‐2,3‐sialyltransferase 1 (ST3Gal1) and vascular endothelial growth factor receptor 2 (VEGF‐R2) in endometrioid‐type epithelial ovarian cancer (E‐OC) because aberrant α2,3‐sialylation mediated by ST3Gal1 and VEGF‐R2‐related angiogenesis is linked with tumor progression. Methods ST3Gal1 and
Wei‐Ting Chao, Chia‐Hao Liu, Szu‐Ting Yang, Chen‐Hao Lin, Liang‐Wei Wang, Peng‐Hui Wang   +5 more
wiley   +1 more source