Results 261 to 270 of about 457,473 (371)

Patient-reported Effects of Fedratinib, an Oral, Selective Inhibitor of Janus Kinase 2, on Myelofibrosis-related Symptoms and Health-related Quality of Life in the Randomized, Placebo-controlled, Phase III JAKARTA Trial. [PDF]

Hemasphere, 2021
Mesa RA, Schaap N, Vannucchi AM, Kiladjian JJ, Passamonti F, Zweegman S, Talpaz M, Verstovsek S, Rose S, Abraham P, Lord-Bessen J, Tang D, Guo S, Ye X, Harrison CN.   +14 more
europepmc   +1 more source

Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer [PDF]

, 2017
Chen, Ina, et al,
core   +2 more sources

JI‐CJ002 and Dabrafenib Combination Enhances Antitumor Activity in Melanoma Associated With the Downregulation of B7‐H3

Cancer Science, EarlyView.
Schematic pathway diagram illustrating the effects of JI‐CJ002 and dabrafenib on melanoma progression. The combination of JI‐CJ002 and dabrafenib is associated with reduced B7‐H3 expression and modulation of signaling pathways implicated in melanoma progression, including JAK2/STAT3, PI3K/AKT/mTOR, and Rb/E2F1.
Sang‐Eun Lee, Young Ha Kim, Bo Shin Heo, Chunhoo Cheon, Seong‐Gyu Ko   +4 more
wiley   +1 more source

Homeodomain-containing gene 10 contributed to breast cancer malignant behaviors by activating Interleukin-6/Janus kinase 2/Signal transducer and activator of transcription 3 pathway.

Bioengineered, 2022
Shen J, Wang M, Li F, Yan H, Zhou J.
europepmc   +1 more source

Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7 [PDF]

, 2002
Fabrizio Giordanetto, Romano T. Kroemer
openalex   +1 more source

Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors.

ACS Medicinal Chemistry Letters, 2015
A. Hart, Gretchen M. Schroeder, H. Wan, J. Grebinski, J. Inghrim, J. Kempson, Junqing Guo, W. Pitts, J. Tokarski, J. Sack, Javed A Khan, J. Lippy, M. V. Lorenzi, D. You, T. Mcdevitt, R. Vuppugalla, Yueping Zhang, L. Lombardo, G. Trainor, A. Purandare   +19 more
semanticscholar   +1 more source

Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging

Cancer Science, EarlyView.
Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka, Shuhei Hirose, Yu Wang, Tomonori Yaguchi, Kenji Chamoto   +4 more
wiley   +1 more source

Janus Kinase 2 Inhibitor AG490 Inhibits the STAT3 Signaling Pathway by Suppressing Protein Translation of gp130 [PDF]

, 2009
In Ae Seo, Hyun Kyoung Lee, Yoon Kyung Shin, Sang Hwa Lee, Su‐Yeong Seo, Ji Wook Park, Hwan Tae Park   +6 more
openalex   +1 more source

Effect of JAK inhibitors on release of CXCL9, CXCL10 and CXCL11 from human airway epithelial cells [PDF]

, 2015
Barnes, PJ, Donnelly, LE, Fenwick, PS, Macedo, P   +3 more
core   +1 more source

The blockade of Janus kinase-2 (JAK2) signaling ameliorates mouse liver damage due to ischemia and reperfusion

, 2010
Freitas, Maria Cecília de Santos [UNIFESP]
openalex   +1 more source