Results 271 to 280 of about 399,504 (355)

Clinical and Molecular Effect of the Anti–IL‐18 Antibody Aletekitug in Adults With Atopic Dermatitis

Allergy, EarlyView.
At Week 12, aletekitug was associated with a −68.3% percentage change from baseline in EASI score. Aletekitug improved the transcriptional profile of lesional skin towards that of non‐lesional skin at Week 4 and Week 12. Aletekitug was well‐tolerated; no serious adverse event or death occurred, and no patient withdrew due to an adverse event.
Joanne Ellis, Léa Fortunato, Hannah Wajdner, Ester Del Duca, Joanna Barnard, Joanna C. Betts, Swaroop Bose, John Browning, Núria Buil‐Bruna, Scott Van Buren, Eden David, Scott Dinehart, Puneet Dhawan, Yeriel Estrada, Parima Ghafoori, Kiranmai Gumireddy, Zhenghong Li, Wei Jing Loo, Fiona Lovegrove, Jenny Lowe, Lawrence Charles Parish, Will Powley, Naveen Prasad, Joel Correa Da Rosa, Marieta Ruseva, Neda Shokrian, Farhat Syed, Chun‐Hang Tang, Gabriel K. Wong, John B. Kelly, Nicolas Wisniacki, Iain Uings, Emma Guttman‐Yassky   +32 more
wiley   +1 more source

Angiotensin‐II type 1 receptor‐mediated Janus kinase 2 activation induces liver fibrosis

Hepatology, 2014
M. Granzow, R. Schierwagen, S. Klein, B. Kowallick, S. Huss, M. Linhart, Irela Mazar, J. Görtzen, A. Vogt, F. Schildberg, M. Gonzalez-Carmona, A. Wojtalla, B. Krämer, J. Nattermann, S. Siegmund, N. Werner, D. Fürst, W. Laleman, P. Knolle, V. Shah, T. Sauerbruch, J. Trebicka   +21 more
semanticscholar   +1 more source

Targeting Immunologic Pathways in Eosinophilic Granulomatosis With Polyangiitis: Translating Emerging Evidence Into Clinical Practice

Allergy, EarlyView.
ABSTRACT Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare and potentially life‐threatening systemic, inflammatory disease with multi‐organ manifestations, variable presentation and complex pathology. Multiple interconnected immunological pathways are implicated in EGPA pathology, including a type‐2 immune response driving predominantly ...
Harold Wilson‐Morkeh, Lior Seluk, Philipp Bosch, Carolina Aguiar, Jens Thiel, Bernhard Hellmich, Michael E. Wechsler, Salman Siddiqui   +7 more
wiley   +1 more source

MicroRNA-216a inhibits pancreatic cancer by directly targeting Janus kinase 2.

Oncology Report, 2014
Siliang Wang, Xiaodong Chen, M. Tang
semanticscholar   +1 more source

Histopathological Characterization and Differential Expression of miRNAs in Male Pediatric Patients With Lichen Sclerosus

Andrology, EarlyView.
ABSTRACT Background Lichen sclerosus is a chronic, inflammatory, scarring disease of the skin that manifests mostly in the genital region. Objective We studied the histomorphological characteristics, grade, and pattern of inflammation in male pediatric patients with lichen sclerosus.
Valerie Flammang, Arndt Hartmann, Robert Stöhr, Katrin Weigelt, Carol Geppert, Frederik A. Stuebs, Matthias W. Beckmann, Bernd Wullich, Helge Taubert, Marios Marcou, Sven Wach   +10 more
wiley   +1 more source

Statement of Retraction: Homeodomain-containing gene 10 contributed to breast cancer malignant behaviors by activating Interleukin-6/Janus kinase 2/Signal transducer and activator of transcription 3 pathway. [PDF]

Bioengineered
europepmc   +1 more source

Limited efficacy of BMS-911543 in a murine model of Janus kinase 2 V617F myeloproliferative neoplasm [PDF]

, 2015
Anthony D. Pomicter, Anna M. Eiring, Anna V. Senina, Matthew S. Zabriskie, James E. Marvin, Josef T. Prchal, Thomas O’Hare, Michael W. Deininger   +7 more
openalex   +1 more source

When, which and how to switch: Navigating JAK inhibitors in myelofibrosis

British Journal of Haematology, EarlyView.
Navigating choice of JAK inhibitor (JAKi) therapy for patients with myelofibrosis who are JAKi‐naïve and for those who have previously been treated with a JAKi.
Jennifer O'Sullivan, Imran Omerdeen, Bethan Psaila   +2 more
wiley   +1 more source

Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7 [PDF]

, 2002
Fabrizio Giordanetto, Romano T. Kroemer
openalex   +1 more source

The Janus Kinase 2 Inhibitor Fedratinib Inhibits Thiamine Uptake: A Putative Mechanism for the Onset of Wernicke’s Encephalopathy

Drug Metabolism And Disposition, 2014
Qiang Zhang, Yan Zhang, S. Diamond, J. Boer, Jennifer J. Harris, Yu Li, Mark J. Rupar, E. Behshad, Christine M. Gardiner, P. Collier, Phillip C. C. Liu, T. Burn, R. Wynn, G. Hollis, S. Yeleswaram   +14 more
semanticscholar   +1 more source