Results 191 to 200 of about 74,157 (302)

Janus Kinase Inhibitors for Treatment of Palmoplantar Pustulosis, Generalized Pustular Psoriasis, and Palmoplantar Pustular Psoriasis: A Systematic Review of the Literature. [PDF]

Health Sci Rep
Ansari MS, Heidari S, Pourgholi E, Bahramian S, Tootoonchi N, Vahabi SM.   +5 more
europepmc   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

Comparative ocular safety of dupilumab and oral Janus kinase inhibitors in atopic dermatitis: A real-world propensity-matched analysis. [PDF]

JAAD Int
Adler R, Kozlov M, Stratigakis N, Gandhi I, Lohani D, Mehta MD, Cowen E, Svigos K, Feig JL.   +8 more
europepmc   +1 more source

JI‐CJ002 and Dabrafenib Combination Enhances Antitumor Activity in Melanoma Associated With the Downregulation of B7‐H3

Cancer Science, EarlyView.
Schematic pathway diagram illustrating the effects of JI‐CJ002 and dabrafenib on melanoma progression. The combination of JI‐CJ002 and dabrafenib is associated with reduced B7‐H3 expression and modulation of signaling pathways implicated in melanoma progression, including JAK2/STAT3, PI3K/AKT/mTOR, and Rb/E2F1.
Sang‐Eun Lee, Young Ha Kim, Bo Shin Heo, Chunhoo Cheon, Seong‐Gyu Ko   +4 more
wiley   +1 more source

Next-generation Janus kinase inhibitors: Integrating synthetic innovation, structural biology, and computational design for precision drug discovery. [PDF]

Pharm Sci Adv
Karunakar KK, Cheriyan BV, Philiph S, Shanmugam RK, Sree J.   +4 more
europepmc   +1 more source

Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging

Cancer Science, EarlyView.
Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka, Shuhei Hirose, Yu Wang, Tomonori Yaguchi, Kenji Chamoto   +4 more
wiley   +1 more source

Systemic Inflammation Marker Alterations in Severe Alopecia Areata Patients Treated with Janus Kinase Inhibitors. [PDF]

J Clin Med
Sahin G, Aydin F, Pancar Yuksel E.
europepmc   +1 more source

From Sprinters to Marathoners: Rethinking Therapeutic Speed and Disease Modification in Atopic Dermatitis

Allergy, EarlyView.
Thomas Bieber, Felix Lauffer
wiley   +1 more source

Janus kinase inhibitors in pulmonary and extra-pulmonary sarcoidosis: A case series and a systematic review of the literature. [PDF]

Sarcoidosis Vasc Diffuse Lung Dis
Quaggetto M, Ben Salem T, Haroche J, Campagne J, Moyon Q, Lhote R, Amoura Z, Cohen Aubart F.   +7 more
europepmc   +1 more source

Effect of Delgocitinib Cream on Health‐Related Quality of Life in Patients With Moderate to Severe Chronic Hand Eczema

Contact Dermatitis, EarlyView.
Patient‐reported outcomes are an important complement to physician‐assessed clinical outcome measures in Chronic Hand Eczema. In a pooled analysis of two randomised, controlled trials, twice‐daily treatment with delgocitinib cream 20 mg/g significantly improved the health‐related quality of life of patients with moderate to severe Chronic Hand Eczema ...
Andrea Bauer, Lyn Guenther, Richard Woolf, Eydna Didriksen Apol, Douglas Maslin, Nanna Nyholm, Henrik Thoning, Marie Louise Schuttelaar   +7 more
wiley   +1 more source