Results 41 to 50 of about 48,562 (198)

The rationale for Janus kinase inhibitors for the treatment of spondyloarthritis [PDF]

Rheumatology, 2018
The pathogenesis of SpA is multifactorial and involves a range of immune cell types and cytokines, many of which utilize Janus kinase (JAK) pathways for signaling. In this review, we summarize the animal and pre-clinical data that have demonstrated the effects of JAK blockade on the underlying molecular mechanisms of SpA and provide a rationale for JAK
Veale, Douglas J., McGonagle, Dennis, McInnes, Iain B., Krueger, James G., Ritchlin, Christopher T., Elewaut, Dirk, Kanik, Keith S., Hendrikx, Thijs, Berstein, Gabriel, Hodge, Jennifer, Telliez, Jean-Baptiste   +10 more
openaire   +7 more sources

Janus kinase inhibitors for the treatment of COVID-19

Cochrane Database of Systematic Reviews, 2022
With potential antiviral and anti-inflammatory properties, Janus kinase (JAK) inhibitors represent a potential treatment for symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. They may modulate the exuberant immune response to SARS-CoV-2 infection. Furthermore, a direct antiviral effect has been described.
Andre, Kramer, Carolin, Prinz, Falk, Fichtner, Anna-Lena, Fischer, Volker, Thieme, Felicitas, Grundeis, Manuel, Spagl, Christian, Seeber, Vanessa, Piechotta, Maria-Inti, Metzendorf, Martin, Golinski, Onnen, Moerer, Caspar, Stephani, Agata, Mikolajewska, Stefan, Kluge, Miriam, Stegemann, Sven, Laudi, Nicole, Skoetz   +17 more
openaire   +3 more sources

Janus Kinase (JAK) Inhibitors in Rheumatoid Arthritis

JK Science, 2022
Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signalling has been established to have pathophysiological role in multiple disease states, such as myeloproliferative neoplasms, rheumatoid arthritis, inflammatory bowel ...
Vishal R. Tandon, Annil Mahajan
doaj  

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival [PDF]

, 2012
Recent evidence suggests CML stem cells are insensitive to kinase inhibitors and responsible for minimal residual disease in treated patients. We investigated whether CML stem cells, in a transgenic mouse model of CML-like disease or derived from ...
Allan, Elaine K., Mueller-Tidow, Carsten, Nicolini, Franck E., Bhatia, Ravi, Brunton, Valerie G, Myssina, Svetlana, Hamilton, Ashley, Mysina, Svetlana, Müller-Tidow, Carsten, Koschmieder, Steffen, Allan, Elaine K, Helgason, G. Vignir, Helgason, G Vignir, Brunton, Valerie G., Schemionek, Mirle, Zhang, Bin, Holyoake, Tessa L., Holyoake, Tessa L, Nicolini, Franck E   +18 more
core   +1 more source

The Era of Janus Kinase Inhibitors for Inflammatory Bowel Disease Treatment

, 2021
For a significant proportion of patients with inflammatory bowel disease (IBD), primary non-response and secondary loss of response to treatment remain significant issues. Anti-tumor necrosis factor therapies have been licensed for use in IBD.
Su-Young Kim, Jin-Woo Kim
core   +1 more source

Potential applications of JAK inhibitors, clinically approved drugs against autoimmune diseases, in cancer therapy

Frontiers in Pharmacology
Disturbances in immunoregulation may lead to both cancer and autoimmune diseases. Many therapeutic drugs for autoimmune diseases also display anti-tumor efficacy.
Xiao-Huan Wei, Xiao-Huan Wei, Xiao-Huan Wei, Yuan-Yuan Liu, Yuan-Yuan Liu   +4 more
doaj   +1 more source

Tyrosine kinase 2 and Janus kinase‒signal transducer and activator of transcription signaling and inhibition in plaque psoriasis [PDF]

, 2022
Plaque psoriasis is a common, chronic, systemic, immune-mediated inflammatory disease. The Janus kinase-signal transducer and activator of transcription pathway plays a major role in intracellular cytokine signaling in inflammatory processes involved in ...
Blauvelt, Andrew, McInnes, Iain B., Krueger, James G.   +2 more
core   +1 more source

Treatments for actinic prurigo: A case report with upadacitinib and systematic review

SAGE Open Medical Case Reports
This study aims to evaluate treatments for actinic prurigo, a chronic, photosensitive dermatosis disproportionately affecting Indigenous populations.
Jonah W. Perlmutter, Romy Levy, Cathryn Sibbald   +2 more
doaj   +1 more source

Janus Kinase inhibitors in dermatology: a review

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2023
Janus Kinases (JAKs) are a subset of cytoplasmic protein tyrosine kinases (TYK), crucial for the initiation of signaling pathways activated by cytokines through phosphorylation and activation of the signal transducer and activator of transcription (STAT)
Bárbara Vieira-Granja, Sofia Magina
doaj  

Acneiform Lesions but not Acne after Treatment with Janus Kinase Inhibitors: Diagnosis and Management of Janus Kinase-acne

Acta Dermato-Venereologica, 2023
is missing (Short communication)
Fabienne Ballanger, Nicole Auffret, Marie-Thérèse Leccia, Jean Paul Claudel, Brigitte Dréno   +4 more
doaj   +1 more source