Results 61 to 70 of about 74,157 (302)

Efficacy of tofacitinib monotherapy in methotrexate-naive patients with early or established rheumatoid arthritis. [PDF]

, 2016
IntroductionTofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). Tofacitinib monotherapy was previously shown to inhibit structural damage, reduce clinical signs and symptoms of RA, and improve physical ...
DeMasi, Ryan, Fleischmann, Roy M, Huizinga, Tom WJ, Kavanaugh, Arthur F, Kwok, Kenneth, van Vollenhoven, Ronald F, Wilkinson, Bethanie   +6 more
core   +3 more sources

The rationale for Janus kinase inhibitors for the treatment of spondyloarthritis [PDF]

Rheumatology, 2018
The pathogenesis of SpA is multifactorial and involves a range of immune cell types and cytokines, many of which utilize Janus kinase (JAK) pathways for signaling. In this review, we summarize the animal and pre-clinical data that have demonstrated the effects of JAK blockade on the underlying molecular mechanisms of SpA and provide a rationale for JAK
Veale, Douglas J., McGonagle, Dennis, McInnes, Iain B., Krueger, James G., Ritchlin, Christopher T., Elewaut, Dirk, Kanik, Keith S., Hendrikx, Thijs, Berstein, Gabriel, Hodge, Jennifer, Telliez, Jean-Baptiste   +10 more
openaire   +7 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Janus kinase inhibitors in the treatment of psoriatic arthritis

Современная ревматология, 2022
The article presents an analysis of literature data on the use of a new group of targeted synthetic disease-modifying antirheumatic drugs (DMARDs) Janus kinase (JAK) inhibitors – tofacitinib (TOFA) and upadacitinib (UPA) – in psoriatic arthritis (PsA ...
E. Yu. Loginova, T. V. Korotaeva
doaj   +1 more source

MTOR cross-talk in cancer and potential for combination therapy [PDF]

, 2018
The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C., Bria, E., Ciuffreda, L., Cognetti, F., Conciatori, F., Falcone, I., Milella, M, Pilotto, S.   +7 more
core   +3 more sources

Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern. The fragile balance between infections and autoimmunity [PDF]

, 2020
On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency.
Diamanti, A. P., Lagana, B., Pioli, C., Rosado, M. M., Sesti, G.   +4 more
core   +2 more sources

Janus kinase inhibitors for the treatment of COVID-19

Cochrane Database of Systematic Reviews, 2022
With potential antiviral and anti-inflammatory properties, Janus kinase (JAK) inhibitors represent a potential treatment for symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. They may modulate the exuberant immune response to SARS-CoV-2 infection. Furthermore, a direct antiviral effect has been described.
Andre, Kramer, Carolin, Prinz, Falk, Fichtner, Anna-Lena, Fischer, Volker, Thieme, Felicitas, Grundeis, Manuel, Spagl, Christian, Seeber, Vanessa, Piechotta, Maria-Inti, Metzendorf, Martin, Golinski, Onnen, Moerer, Caspar, Stephani, Agata, Mikolajewska, Stefan, Kluge, Miriam, Stegemann, Sven, Laudi, Nicole, Skoetz   +17 more
openaire   +3 more sources

Seta‐Inspired Mechano‐Intelligent Janus Bandage with Coordinated Adhesion–Contraction for Minimizing Scarring

Advanced Materials, EarlyView.
We developed a bioinspired mechano‐intelligent Janus bandage (MIB) with a hydrophobic flat exterior and a hydrophilic interior featuring gecko‐mimicking wedged microstructures, fabricated via micromolding and anisotropic plasma treatment. The MIB dynamically synchronizes adhesion and contraction, enabling precise force modulation.
Di Suo, Yuhe Yang, Shuai Zhao, Ho‐Pan Bei, Avery Chik‐Him Lam, Wei‐Qiang Tan, Kenneth Kak‐yuen Wong, Xin Zhao   +7 more
wiley   +1 more source

Potential applications of JAK inhibitors, clinically approved drugs against autoimmune diseases, in cancer therapy

Frontiers in Pharmacology
Disturbances in immunoregulation may lead to both cancer and autoimmune diseases. Many therapeutic drugs for autoimmune diseases also display anti-tumor efficacy.
Xiao-Huan Wei, Xiao-Huan Wei, Xiao-Huan Wei, Yuan-Yuan Liu, Yuan-Yuan Liu   +4 more
doaj   +1 more source

Janus Kinase (JAK) Inhibitors in Rheumatoid Arthritis

JK Science, 2022
Janus kinase (JAK) and signal transducer and activator of transcription (STAT) signalling has been established to have pathophysiological role in multiple disease states, such as myeloproliferative neoplasms, rheumatoid arthritis, inflammatory bowel ...
Vishal R. Tandon, Annil Mahajan
doaj