Results 51 to 60 of about 48,562 (198)

Rapid resolution of non-segmental vitiligo in a patient treated with abrocitinib: A case report

SAGE Open Medical Case Reports
Vitiligo is a common, autoimmune, depigmenting disorder of the skin. Janus Kinase inhibitors have emerged as promising topical and oral therapeutic options for vitiligo.
Seyyon Satkunanathan, Mina Boshra, Janis Chang, Reetesh Bose   +3 more
doaj   +1 more source

Evaluating Janus Kinase Inhibitors as Target Therapies in Atopic Dermatitis

, 2022
Atopic dermatitis (AD) pathogenesis involves cytokines that harness the Janus kinase/signal transducer and activator of the transcription (JAK-STAT) signaling cascade.1 For this reason, Janus Kinase inhibitors (JAKi) are target therapies in AD.1 This ...
Reno, Hunter
core  

Cooperative effects of Janus and Aurora kinase inhibition by CEP701 in cells expressing Jak2V617F [PDF]

, 2013
peer reviewedThe Janus kinase 2 mutant V617F occurs with high frequency in myeloproliferative neoplasms. Further mutations affecting the Janus kinase family have been discovered mostly in leukaemias and in myeloproliferative neoplasms.
Eulenfeld, R., Palissot, V., BEHRMANN, Iris, Berchem, G., ROLVERING, Catherine, Méndez, S. A., Gäbler, Karoline, KACZOR, Jakub, HAAN, Claude   +8 more
core   +1 more source

Indirect inhibition of the NLRP3-interleukin-1β axis contributes to the efficacy of JAK1 inhibitors in experimental colitis and human ulcerative colitis

Nature Communications
Tofacitinib, a pan–Janus kinase inhibitor, and the Janus kinase 1–preferential inhibitors Upadacitinib and Filgotinib are approved for the treatment of ulcerative colitis, yet their molecular mechanisms of action remain incompletely understood.
Beibei Liu, Marianne R. Spalinger, Annalisa Invernizzi, Eike Gerdes, Babett Steglich, Marlene Schwarzfischer, Andres Machicote, Penelope Pelczar, Doris Pöhlmann, Mikolaj Nawrocki, Marius Böttcher, Ayob Aleko, Lis Noelia Velasquez, Sandra Wende, Franziska Stallbaum, Justus Neuendorff, Saskia Grosshauser, Franziska Muscate, Gemma Douilhet, Laura Garcia Perez, Morsal Sabihi, Katharina Möller, Florian Viehweger, Jan P. Sutter, Christoph Kilian, Yogesh Kumar, Thorben Fründt, Guido Sauter, Thomas Rösch, Nicola Gagliani, Amedeo Caflisch, Michael Scharl, Samuel Huber   +32 more
doaj   +1 more source

Treatment of rheumatoid arthritis with janus kinase inhibitors [PDF]

Rheumatoid arthritis (RA) is a frequent systemic inflammatory polyarthritis. In recent years, considerable knowledge has been gained in the treatment and diagnosis field.
Lomborg, Niels, Thorhauge, Pernille Holme, Ottesen, Anders Løkke   +2 more
core   +1 more source

Modern Management Approaches for Alopecia Areata

Вопросы современной педиатрии
Alopecia areata is a chronic genetically determined inflammatory autoimmune disease damaging hair follicles and leading to temporary or persistent nonscarring hair loss.
Eduard T. Ambarchyan, Vladislav V. Ivanchikov, Anastasiya D. Alekseeva, Olga B. Gordeeva, Leyla S. Namazova-Baranova   +4 more
doaj   +1 more source

A novel treatment for psoriatic arthritis: Janus kinase inhibitors

Chinese Medical Journal, 2020
. Psoriatic arthritis (PsA) is a type of chronic inflammatory arthritis which is associated with psoriasis. The early recognition and treatment for PsA are of critical importance.
Miao Chen, Sheng-Ming Dai, Li-Shao Guo
doaj   +1 more source

Janus kinase-1 and Janus kinase-2 inhibitors for treating myelofibrosis

, 2013
This is the protocol for a review and there is no abstract. The objectives are as follows: To determine the clinical efficacy and safety of JAK1 and JAK2 inhibitors for treating MF generated by hematologic or non-hematologic conditions. © 2013 The Cochrane Collaboration.
Martí-Carvajal A.J., Cardona A.F., Anand V., Solà I.   +3 more
openaire   +2 more sources

Janus kinase inhibitors in dermatology: Part II. A comprehensive review

, 2021
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) intracellular signaling pathway is implicated in the pathogenesis of a number of inflammatory dermatoses. Clinical trials and other studies have demonstrated the efficacy of JAK
Chapman, Stephanie, Lim, Henry W, Stein Gold, Linda F   +2 more
core  

Figure S1 - Supplemental material for The Use of Janus Kinase Inhibitors for Lichen Planus: An Evidence-Based Review

, 2023
Supplemental material, Figure S1, for The Use of Janus Kinase Inhibitors for Lichen Planus: An Evidence-Based Review by Abrahim Abduelmula, Ahmed Bagit, Asfandyar Mufti, Katie C.Y.
Ahmed Bagit (12573562), Asfandyar Mufti (9700375), Katie C.Y. Yeung (14671852), Jensen Yeung (5170499), Abrahim Abduelmula (10488626)   +4 more
core   +1 more source