A rare urinary JC virus reactivation after long-term therapy with rituximab [PDF]
International Journal of Infectious Diseases, 2021 The possible role of JC virus in determining urinary tract involvement has only recently been recognized. The case of a man with laboratory-confirmed JC virus replication in the urine after a maintenance schedule of rituximab administered for a ...
Fabrizio Di Maida +8 more
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Adaptive mutations in the JC virus protein capsid are associated with progressive multifocal leukoencephalopathy (PML). [PDF]
PLoS Genetics, 2009 PML is a progressive and mostly fatal demyelinating disease caused by JC virus infection and destruction of infected oligodendrocytes in multiple brain foci of susceptible individuals.
Shamil R Sunyaev +3 more
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Human polyomavirus JC virus genome [PDF]
Journal of Virology, 1984 The complete DNA sequence of the human JC virus, which was found to consist of 5,130 nucleotide pairs, is presented. The amino acid sequence of six proteins could be deduced: the early, nonstructural proteins, large T and small t antigens; the late capsid proteins, VP1, VP2, and VP3; and the agnogene product encoded within the late leader sequence ...
Richard J. Frisque +2 more
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JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patient [PDF]
BMC Neurology, 2022 Background JC virus (JCV) is common among healthy individuals and remains latent but may be reactivated under immunosuppressive conditions, resulting in progressive multifocal leukoencephalopathy (PML).
Xiang Wang +4 more
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JC virus detection and JC virus-specific immunity in natalizumab-treated Multiple Sclerosis patients [PDF]
Journal of Translational Medicine, 2012 Background The use of natalizumab in multiple sclerosis (MS) may favour JC virus reactivation; this phenomenon is usually asymptomatic but can, albeit rarely, evolve into frank progressive multifocal leucoencephalopathy (PML). Methods JCV-specific CD8+ T
Mancuso Roberta +8 more
doaj +5 more sources
Progressive Multifocal Leukoencephalopathy in a HIV-Negative Patient with Small Lymphocytic Leukemia following Treatment with Rituximab [PDF]
Case Reports in Oncology, 2011 We describe a case of progressive multifocal leukoencephalopathy (PML) caused by infection with the human polyomavirus JC virus in a patient with B-cell small lymphocytic leukemia who was treated with rituximab.
Subhankar Chakraborty +5 more
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Oligosaccharides as Receptors for JC Virus [PDF]
Journal of Virology, 2002 ABSTRACT JC virus (JCV) belongs to the polyomavirus family of double-stranded DNA viruses and in humans causes a demyelinating disease of the central nervous system, progressive multifocal leukoencephalopathy. Its hemagglutination activity and entry into host cells have been reported to depend on an N-linked glycoprotein containing sialic ...
Rika Komagome +6 more
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Newly diagnosed AIDS patient with cerebellar JC virus [PDF]
IDCases, 2023 We present a case of a 57-year-old man with newly diagnosed acquired immunodeficiency syndrome (AIDS) infection who initially sought care for progressive dysarthria and gait instability.
Sergio Alvarez-Mulett +2 more
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Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus [PDF]
BMC Cancer, 2005 Background p53 mutations are relatively uncommon in medulloblastoma, but abnormalities in this cell cycle pathway have been associated with anaplasia and worse clinical outcomes. We correlated p53 protein expression with pathological subtype and clinical
Shah Keerti V +5 more
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JC Polyomavirus-Associated Nephropathy Case Report: Clinical and Laboratory Learning [PDF]
British Journal of Biomedical ScienceIntroductionJohn Cunningham (JC) virus is commonly associated with progressive multifocal leukoencephalopathy. However, this polyomavirus can also be a rare etiological agent of nephropathy in renal transplant recipients.
Rachael M. Tomb +5 more
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