JC virus detection and JC virus-specific immunity in natalizumab-treated Multiple Sclerosis patients [PDF]
Journal of Translational Medicine, 2012 Background The use of natalizumab in multiple sclerosis (MS) may favour JC virus reactivation; this phenomenon is usually asymptomatic but can, albeit rarely, evolve into frank progressive multifocal leucoencephalopathy (PML). Methods JCV-specific CD8+ T
Mancuso Roberta +8 more
doaj +6 more sources
Fatal encephalopathy with wild-type JC virus and ruxolitinib therapy. [PDF]
Ann Neurol, 2019 JC virus (JCV) infection is a lytic infection of oligodendrocytes in progressive multifocal leukoencephalopathy; less common forms of central nervous system manifestations associated with JCV infection include granule cell neuronopathy, encephalopathy ...
Reoma LB +14 more
europepmc +4 more sources
Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease. [PDF]
Nat Rev Neurol, 2021 Progressive multifocal leukoencephalopathy (PML) is a devastating CNS infection caused by JC virus (JCV), a polyomavirus that commonly establishes persistent, asymptomatic infection in the general population. Emerging evidence that PML can be ameliorated
Cortese I, Reich DS, Nath A.
europepmc +2 more sources
Adoptive Transfer of JC Virus-Specific T Lymphocytes for the Treatment of Progressive Multifocal Leukoencephalopathy. [PDF]
Ann Neurol, 2021 Progressive multifocal leukoencephalopathy (PML) is still burdened by high mortality in a subset of patients, such as those affected by hematological malignancies.
Berzero G +21 more
europepmc +2 more sources
Trafficking of JC virus-like particles across the blood-brain barrier. [PDF]
Nanoscale Adv, 2021 Hollow viral vectors, such as John Cunningham virus-like particles (JC VLPs), provide a unique opportunity to deliver drug cargo into targeted cells and tissue. Current understanding of the entry of JC virus in brain cells has remained insufficient.
Ye D +13 more
europepmc +2 more sources
The Role of the JC Virus in Central Nervous System Tumorigenesis. [PDF]
Int J Mol Sci, 2020 Cancer is the second leading cause of mortality worldwide. The study of DNA tumor-inducing viruses and their oncoproteins as a causative agent in cancer initiation and tumor progression has greatly enhanced our understanding of cancer cell biology.
Ahye N, Bellizzi A, May D, Wollebo HS.
europepmc +2 more sources
JC virus-induced progressive multifocal leukoencephalopathy in a presumably healthy patient [PDF]
BMC Neurology, 2022 Background JC virus (JCV) is common among healthy individuals and remains latent but may be reactivated under immunosuppressive conditions, resulting in progressive multifocal leukoencephalopathy (PML).
Xiang Wang +4 more
doaj +2 more sources
Progressive multifocal leukoencephalopathy in a patient post allo-HCT successfully treated with JC virus specific donor lymphocytes [PDF]
Journal of Translational Medicine, 2020 Background Progressive multifocal leukoencephalopathy is a demyelinating CNS disorder. Reactivation of John Cunningham virus leads to oligodendrocyte infection with lysis and consequent axonal loss due to demyelination.
Maximilian Steinhardt +19 more
openalex +2 more sources
Newly diagnosed AIDS patient with cerebellar JC virus [PDF]
IDCases, 2023 We present a case of a 57-year-old man with newly diagnosed acquired immunodeficiency syndrome (AIDS) infection who initially sought care for progressive dysarthria and gait instability.
Sergio Alvarez-Mulett +2 more
doaj +2 more sources
Fatal ruxolitinib-related JC virus meningitis
Journal of NeuroVirology, 2017 We report a possible association between ruxolitinib and JC virus meningitis. A 72-year-old man with myelofibrosis started treatment with ruxolitinib. Fourteen days later, the patient presented to the emergency department with fever and nausea. HIV test was negative. Ruxolitinib was suspended.
Begoña Ballesta +3 more
semanticscholar +7 more sources