Results 101 to 110 of about 128,017 (118)

Insulin–Dendrimer Nanocomplex for Multi‐Day Glucose‐Responsive Therapy in Mice and Swine

Advances in Materials, 2023
The management of diabetes in a manner offering autonomous insulin therapy responsive to glucose‐directed need, and moreover with a dosing schedule amenable to facile administration, remains an ongoing goal to improve the standard of care.
Sijie Xian, Yuanhui Xiang, Dongping Liu, Bowen Fan, Katarína Mitrová, Rachel C. Ollier, Bo Su, M. Alloosh, Jiří Jiráček, Michael Sturek, M. Alloosh, M. Webber   +11 more
semanticscholar   +1 more source

Insulin Analogues with Altered Insulin Receptor Isoform Binding Specificities and Enhanced Aggregation Stabilities.

Journal of Medicinal Chemistry, 2021
Insulin is a lifesaver for millions of diabetic patients. There is a need for new insulin analogues with more physiological profiles and analogues that will be thermally more stable than human insulin.
T. Páníková, K. Mitrová, Tereza Halamová, Karolína Mrzílková, J. Pícha, Martina Chrudinová, A. Kurochka, I. Selicharová, L. Žáková, J. Jiráček   +9 more
semanticscholar   +1 more source

Chiral analysis of -alanyl-d,l-tyrosine and its derivatives and estimation of binding constants of their complexes with 2-hydroxypropyl-β-cyclodextrin by capillary electrophoresisS.

Journal of Separation Science, 2022
Chiral CE methods were developed for elucidation of l- or d-configuration of tyrosine residue in antimicrobial dipeptide β-alanyl-tyrosine (β-Ala-Tyr) isolated from hemolymph of larvae of fleshfly Neobellieria bullata and for evaluation of enantiopurity ...
P. Sázelová, Veronika Šolínová, Tereza Schimperková, J. Jiráček, V. Kašička   +4 more
semanticscholar   +1 more source

Diboronate-Modified Hyaluronic Acid for Glucose-Responsive Insulin Delivery.

Biomacromolecules
Diabetes requires precise insulin management to maintain glycemic control and prevent severe complications. Glucose-responsive delivery systems envision an autonomous approach to improve insulin therapy.
Sijie Xian, Yuanhui Xiang, Katarína Mitrová, Jiří Jiráček, Matthew J. Webber   +4 more
semanticscholar   +1 more source

Functional stapled fragments of human preptin of minimised length.

Organic and biomolecular chemistry, 2022
Preptin is a 34-amino-acid-long peptide derived from the E-domain of a precursor of insulin-like growth factor 2 (pro-IGF2) with bone-anabolic and insulin secretion amplifying properties.
Marta Lubos, L. Mrázková, Petra Gwozdiaková, J. Pícha, M. Buděšínský, J. Jiráček, Jakub Kaminský, L. Žáková   +7 more
semanticscholar   +1 more source

Targeting the insulin receptor with hormone and peptide dimers

Journal of Peptide Science, 2022
Insulin is a key hormone involved in the regulation of overall energetic homeostasis of the organism. The dimeric character of the receptor for insulin evokes ideas about its activation or inhibition with peptide dimers that could either trigger or block
Jingjing Lin, I. Selicharová, K. Mitrová, B. Fabre, V. M. Miriyala, M. Lepšík, J. Jiráček, María Soledad Garre Hernández   +7 more
semanticscholar   +1 more source