Results 51 to 60 of about 297,973 (327)
International Journal of COPD, 2023 Chen Z, Zhang Y, Wu J, et al. Int J Chron Obstruct Pulmon Dis. 2021;16:877–885. The Editor and Publisher of International Journal of Chronic Obstructive Pulmonary Disease are retracting the published article.
Chen Z +7 more
doaj
JNK isoforms control mammal adult hippocampal neurogenesis
Mexican Journal of Medical Research ICSA, 2020 In mammals, the term “adult hippocampal neurogenesis” defines the process through which, throughout adulthood, new granular neurons are produced by neural stem cells (NSC) in the subgranular zone (SGZ) in the dentate gyrus (DG) of the hippocampus or, by ...
Carme Auladell +5 more
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Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: Implication for neuroprotective therapies [PDF]
, 2013 Neuroprotective therapies based on brain-derived neurotrophic factor (BDNF) administration have been proposed for Huntington's disease (HD) treatment. However, our group has recently reported reduced levels of TrkB in HD mouse models and HD human brain ...
Alberch, J. +5 more
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The Role of JNk Signaling Pathway in Obesity-Driven Insulin Resistance
Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2020 Obesity is not only closely related to insulin resistance but is one of the main factors leading to the formation of Type 2 Diabetes (T2D) too.
Jia Feng +8 more
semanticscholar +1 more source
Bistability in the JNK cascade [PDF]
Current Biology, 2001 Important signaling properties, like adaptation, oscillations, and bistability, can emerge at the level of relatively simple systems of signaling proteins. Here, we have examined the quantitative properties of one well-studied signaling system, the JNK cascade.
Bagowski, Christoph P, Ferrell, James E
openaire +2 more sources
Drug Design, Development and Therapy, 2020 Peng Sun,1,2 Qichang Yang,1 Yanben Wang,2 Jiaxuan Peng,3 Kangxian Zhao,1 Yewei Jia,2 Tan Zhang,2 Xuanyuan Lu,2 Weiqi Han,2 Yu Qian1,2 1The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang ...
Sun P +9 more
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Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogenactivated protein kinases in THP-1 monocytic cells [PDF]
, 2006 Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins. Normally, MMP-9 expression is tightly controlled in cells. Sustained or
Bogoyevitch +13 more
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The ERK and JNK pathways in the regulation of metabolic reprogramming
Oncogene, 2018 Most tumor cells reprogram their glucose metabolism as a result of mutations in oncogenes and tumor suppressors, leading to the constitutive activation of signaling pathways involved in cell growth.
S. Papa, Pui Man Choy, C. Bubici
semanticscholar +1 more source
Molecules and Cells, 2006 The literature provides strong precedent for both pro-tumorigenic and tumor suppressor roles for the c-Jun N-terminal kinases (JNKs) in the setting of oncogenesis. Clearly, JNKs are activated by numerous oncogenes and growth factors and the literature documents a role for these MAP kinases in cell proliferation and transformation.
Lynn E, Heasley, Sun-Young, Han
openaire +2 more sources
Role of G{alpha}12 and G{alpha}13 as Novel Switches for the Activity of Nrf2, a Key Antioxidative Transcription Factor [PDF]
, 2007 G{alpha}12 and G{alpha}13 function as molecular regulators responding to extracellular stimuli. NF-E2-related factor 2 (Nrf2) is involved in a protective adaptive response to oxidative stress.
Cho, Min Kyung +6 more
core +2 more sources