Results 91 to 100 of about 161,447 (312)

Dual p38/JNK Mitogen Activated Protein Kinase Inhibitors Prevent Ozone-Induced Airway Hyperreactivity in Guinea Pigs

PLoS ONE, 2013
Ozone exposure causes airway hyperreactivity and increases hospitalizations resulting from pulmonary complications. Ozone reacts with the epithelial lining fluid and airway epithelium to produce reactive oxygen species and lipid peroxidation products, which then activate cell signaling pathways, including the mitogen activated protein kinase (MAPK ...
Kirsten C Verhein, Francesco G Salituro, Mark W Ledeboer, Allison D Fryer, David B Jacoby   +4 more
openaire   +4 more sources

Calcium retinoate nanoparticle mediated microglial polarization to regulate inflammatory microenvironment for therapy of neuroinflammatory disease

BMEMat, EarlyView.
A nano‐drug based on retinoic acid and calcium is developed, which can be rapily endocytosed by microglia and decomposed into small molecule/ion storms in lysosomes. This nano‐drug regulates microglial phenotype switching from M1 to M2 while indirectly guiding neuronal differentiation of endogenous neural stem cells, thereby ameliorating ...
Shuo Zhang, Yuan Yao, Wenfeng Shao, Jiapei Shi, Benjie Wei, Chunhui Sun, Jingang Wang, Jiaming Shi, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Na Ren, Yuchun Tang, Wenjuan Zhou, Shuping Wang   +13 more
wiley   +1 more source

Morphine Postconditioning Protects against Reperfusion Injury via Inhibiting JNK/p38 MAPK and Mitochondrial Permeability Transition Pores Signaling Pathways

Cellular Physiology and Biochemistry, 2016
Background: The purpose of this study was to determine whether c-jun NH2 amino-terminal kinases (JNK) and p38 mitogen-activated protein kinases (MAPK) were involved in morphine postconditioning (MpostC).
Zuolei Chen, Xuewei Zhang, Yingzhi Liu, Zhongkai Liu   +3 more
doaj   +1 more source

Normal mesenteric lymph ameliorates lipopolysaccharide challenge-induced spleen injury [PDF]

Acta Cirúrgica Brasileira, 2015
PURPOSE: This study was conducted to investigate the effect of normal mesenteric lymph (NML) from mice on the spleen injury induced by lipopolysaccharide (LPS) challenge.METHODS: Mice in the LPS and LPS+NML groups received an intraperitoneal injection of
Li-min Zhang, Wen Song, Hao Cui, Li-qiang Xing, Hui-bo Du, Ying Cui, Wei-hong Chen, Zi-gang Zhao, Chun-yu Niu   +8 more
doaj   +1 more source

Cell Surface AMPA Receptors in the Rat Nucleus Accumbens Increase during Cocaine Withdrawal But Internalize after Cocaine Challenge in Association with Altered Activation of Mitogen-Activated Protein Kinases

Journal of Neuroscience, 2007
Although some studies report increased responsiveness of nucleus accumbens (NAc) AMPA receptors (AMPARs) after withdrawal from repeated cocaine treatment, others report decreased responsiveness after withdrawal plus cocaine challenge.
Amy C. Boudreau, Jeremy M. Reimers, M. Milovanovic, M. Wolf   +3 more
semanticscholar   +1 more source

Activation of G1 Progression, JNK Mitogen-activated Protein Kinase, and Actin Filament Assembly by the Exchange Factor FGD1 [PDF]

Journal of Biological Chemistry, 1998
Cdc42 has been shown to control bifurcating pathways leading to filopodia formation/G1 cell cycle progression and to JNK mitogen-activated protein kinase activation. To dissect these pathways further, the cellular effects induced by a Cdc42 guanine nucleotide exchange factor, FGD1, have been examined.
K, Nagata, M, Driessens, N, Lamarche, J L, Gorski, A, Hall   +4 more
openaire   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Deregulated JNK signaling enhances apoptosis during hyperthermia

International Journal of Hyperthermia
Purpose c-Jun N-terminal kinases (JNKs) comprise a subfamily of mitogen-activated protein kinases (MAPKs). The JNK group is known to be activated by a variety of stimuli.
Atsushi Enomoto, Takemichi Fukasawa, Hiroshi Terunuma, Keiichi Nakagawa, Ayumi Yoshizaki, Shinichi Sato, Noriko Hosoya, Kiyoshi Miyagawa   +7 more
doaj   +1 more source

Gαi3-dependent inhibition of JNK activity on intracellular membranes

Frontiers in Bioengineering and Biotechnology, 2015
Heterotrimeric G-protein signalling has been shown to modulate a wide variety of intracellular signalling pathways including the mitogen-activated protein kinase (MAPK) family.
Guillaume eBastin, Jin Ye eYang, Scott Patrick Heximer   +2 more
doaj   +1 more source

Activation of mitogen‐activated protein kinases (p38‐MAPKs, SAPKs/JNKs and ERKs) by adenosine in the perfused rat heart [PDF]

FEBS Letters, 1998
Adenosine and mitogen‐activated protein kinases (MAPKs) have been separately implicated in cardiac ischaemic preconditioning. We investigated the activation of MAPK subfamilies by adenosine in perfused rat hearts. p38‐MAPK was rapidly phosphorylated and activated (10‐fold activation, maximal at 5 min) by 10 mM adenosine, as was the p38‐MAPK substrate ...
Haq, Syed E.A., Clerk, Angela, Sugden, Peter H.   +2 more
openaire   +2 more sources