Results 71 to 80 of about 49,266 (275)

IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α

Animal Models and Experimental Medicine, EarlyView.
IRF‐1 modulates hepatic ferroptosis and aggravates liver ischemia/reperfusion injury via DYRK1α. Abstract Background The purpose is to define the contribution of the interferon regulatory factor‐1–dual‐specificity tyrosine phosphorylation‐regulated kinase 1α (IRF‐1–DYRK1α) axis to hepatocellular ferroptosis during liver ischemia/reperfusion injury ...
Jinping Zhang, Jinming Zhang, Siyuan Song, Mingyang Li, Liying Sun, Zhijun Zhu, Dongdong Lin   +6 more
wiley   +1 more source

Post-translational modification and regulation of human Spir protein

, 2011
Spir proteins are the primodial members of the emerging group of actin nucleation factors, which initiate actin polymerization by binding monomeric actin to one or multiple Wiskott-Aldrich Syndrome protein (WASp) homology-2 domains.
Lakshmi, Sreeja
core   +1 more source

Drosophila heat shock response requires the JNK pathway and phosphorylation of mixed lineage kinase at a conserved serine-proline motif. [PDF]

PLoS ONE, 2012
Defining context specific requirements for proteins and pathways is a major challenge in the study of signal transduction. For example, the stress-activated protein kinase (SAPK) pathways are comprised of families of closely related transducers that are ...
Rebecca L Gonda, Rebecca A Garlena, Beth Stronach   +2 more
doaj   +1 more source

Stress‐responsive JNK mitogen‐activated protein kinase mediates aspirin‐induced suppression of B16 melanoma cellular proliferation [PDF]

British Journal of Pharmacology, 2003
Available anticancer drugs do not seem to modify the prognosis of metastatic melanoma. Salicylate and acetyl salicylic acid (aspirin) were found to suppress growth in a number of transformed cells, that is, prostate and colon. Therefore, we studied the direct effects of aspirin on metastatic B16 melanoma cells.
Ordan, O., Rotem, R., Jaspers, I., Flescher, E.   +3 more
openaire   +3 more sources

Cell therapy comparison of dental pulp stem cells, hepatocytes, and their exosomes for liver fibrosis treatment in rats

Animal Models and Experimental Medicine, EarlyView.
DPSCs, hepatocytes, and exosomes were tested for liver fibrosis therapy. Exosome‐based treatment exhibited superior antioxidative and regenerative effects. Liver enzymes, oxidative stress, and profibrotic markers were significantly reduced. α‐SMA, desmin, and related gene expression were downregulated.
Sahar Rahimi, Seyedeh Mahdieh Khoshnazar, Ali Derakhshani, Nader Shahrokhi   +3 more
wiley   +1 more source

Envolvimento das proteínas quinases ativadas por mitógenos espinhais na lesão medular traumática em ratos [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2011O envolvimento das proteínas quinases ativadas por mitógenos (MAPKs) em lesões do sistema ...
Martini, Alessandra Cadete
core  

Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death

Journal of Biomedical Science, 2012
Background Based on an experimental brain stem death model, we demonstrated previously that activation of the mitogen-activated protein kinase kinase 1/2 (MEK1/2)/extracellular signal-regulated kinase 1/2 (ERK1/2)/mitogen-activated protein kinase signal ...
Chang Alice YW
doaj   +1 more source

Ginkgo biloba extract individually inhibits JNK activation and induces c-Jun degradation in human chondrocytes: potential therapeutics for osteoarthritis. [PDF]

PLoS ONE, 2013
Osteoarthritis (OA) is a common joint disorder with varying degrees of inflammation. The ideal anti-OA drug should have immunomodulatory effects while at the same time having limited or no toxicity.
Ling-Jun Ho, Li-Feng Hung, Feng-Cheng Liu, Tsung-Yun Hou, Leou-Chyr Lin, Chuan-Yueh Huang, Jenn-Haung Lai   +6 more
doaj   +1 more source

Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy

Animal Models and Experimental Medicine, EarlyView.
Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan, Khushbakhat Alia, Yusra Al Dhaheri, Muhammad Naseem, Rabah Iratni, Edgar Serfling, Khalid Muhammad   +6 more
wiley   +1 more source

Comparative study of the efficacy of pulsed electromagnetic field and low level laser therapy on mitogen-activated protein kinases

Biochemistry and Biophysics Reports, 2017
Mitogen-Activated Protein Kinases (MAPKs) consist of three major signaling members: extracellular signal-regulated kinase (ERK), p38 and C-JUN N-terminal kinase (JNK).
Ayman M. El-Makakey, Radwa M. El-Sharaby, Mohammed H. Hassan, Alaa Balbaa   +3 more
doaj   +1 more source