Results 91 to 100 of about 79,924 (277)

Caenorhabditis elegans and probiotics interactions from a prolongevity perspective [PDF]

, 2019
Probiotics exert beneficial effects on host health through different mechanisms of action, such as production of antimicrobial substances, competition with pathogens, enhancement of host mucosal barrier integrity and immunomodulation.
Barbara Guantario, Chiara Devirgiliis, Daniela Uccelletti, Marianna Roselli, Paola Zinno, SCHIFANO, EMILY   +5 more
core   +1 more source

Activation of G1 Progression, JNK Mitogen-activated Protein Kinase, and Actin Filament Assembly by the Exchange Factor FGD1 [PDF]

Journal of Biological Chemistry, 1998
Cdc42 has been shown to control bifurcating pathways leading to filopodia formation/G1 cell cycle progression and to JNK mitogen-activated protein kinase activation. To dissect these pathways further, the cellular effects induced by a Cdc42 guanine nucleotide exchange factor, FGD1, have been examined.
K, Nagata, M, Driessens, N, Lamarche, J L, Gorski, A, Hall   +4 more
openaire   +2 more sources

Vitamins as potent cancer treatments through regulating the activity and expression of MMP‐2 and MMP‐9

Bulletin of the Korean Chemical Society, EarlyView.
Vitamins could regulate both MMP‐2 and MMP‐9 expression and activity through transcriptional and MAPK signaling pathway modulation. This study highlights the potential of vitamins as low‐toxicity therapeutic or adjunct agents for targeting MMP‐mediated cancer progression. Abstract Matrix metalloproteinases (MMP‐2 and MMP‐9) are key regulators of cancer
Yen Thi Nguyen, Eungchan Kim, Ha Vy Thi Vo, Song Ja Kim, Namdoo Kim, Hyuck Jin Lee   +5 more
wiley   +1 more source

Morphine Postconditioning Protects against Reperfusion Injury via Inhibiting JNK/p38 MAPK and Mitochondrial Permeability Transition Pores Signaling Pathways

Cellular Physiology and Biochemistry, 2016
Background: The purpose of this study was to determine whether c-jun NH2 amino-terminal kinases (JNK) and p38 mitogen-activated protein kinases (MAPK) were involved in morphine postconditioning (MpostC).
Zuolei Chen, Xuewei Zhang, Yingzhi Liu, Zhongkai Liu   +3 more
doaj   +1 more source

Normal mesenteric lymph ameliorates lipopolysaccharide challenge-induced spleen injury [PDF]

Acta Cirúrgica Brasileira, 2015
PURPOSE: This study was conducted to investigate the effect of normal mesenteric lymph (NML) from mice on the spleen injury induced by lipopolysaccharide (LPS) challenge.METHODS: Mice in the LPS and LPS+NML groups received an intraperitoneal injection of
Li-min Zhang, Wen Song, Hao Cui, Li-qiang Xing, Hui-bo Du, Ying Cui, Wei-hong Chen, Zi-gang Zhao, Chun-yu Niu   +8 more
doaj   +1 more source

Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation [PDF]

, 2019
The aberrant activation of hedgehog (HH) signaling is a leading cause of the development of medulloblastoma, a pediatric tumor of the cerebellum. The FDA‑approved HH inhibitor, Vismodegib, which targets the transmembrane transducer SMO, has shown limited
Agostinelli, Enzo, Antonucci, Laura, Bordone, Rosa, Caimano, Miriam, Canettieri, Gianluca, Capalbo, Carlo, Checquolo, Saula, Coni, Sonia, D'Amico, Davide, De Smaele, Enrico, Di Magno, Laura, Di Marcotullio, Lucia, Di Pastena, Fiorella, Giorgi, Alessandra, Manni, Simona, Maroder, Marella, Petroni, Marialaura, Schininà, Maria Eugenia, Serrao, Silvia Maria, Yates Iii, John R, Yurtsever, Zuleyha Nihan   +20 more
core   +1 more source

Activation of mitogen‐activated protein kinases (p38‐MAPKs, SAPKs/JNKs and ERKs) by adenosine in the perfused rat heart [PDF]

FEBS Letters, 1998
Adenosine and mitogen‐activated protein kinases (MAPKs) have been separately implicated in cardiac ischaemic preconditioning. We investigated the activation of MAPK subfamilies by adenosine in perfused rat hearts. p38‐MAPK was rapidly phosphorylated and activated (10‐fold activation, maximal at 5 min) by 10 mM adenosine, as was the p38‐MAPK substrate ...
Haq, Syed E.A., Clerk, Angela, Sugden, Peter H.   +2 more
openaire   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Gαi3-dependent inhibition of JNK activity on intracellular membranes

Frontiers in Bioengineering and Biotechnology, 2015
Heterotrimeric G-protein signalling has been shown to modulate a wide variety of intracellular signalling pathways including the mitogen-activated protein kinase (MAPK) family.
Guillaume eBastin, Jin Ye eYang, Scott Patrick Heximer   +2 more
doaj   +1 more source

Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7 [PDF]

Biochemical Journal, 2000
Stress-activated protein kinase 1 (SAPK1), also called c-Jun N-terminal kinase (JNK), becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated ...
Y, Fleming, C G, Armstrong, N, Morrice, A, Paterson, M, Goedert, P, Cohen   +5 more
openaire   +2 more sources