Results 61 to 70 of about 49,266 (275)

Distinct Molecular Effects of Angiotensin II and Angiotensin III in Rat Astrocytes

International Journal of Hypertension, 2013
It is postulated that central effects of angiotensin (Ang) II may be indirect due to rapid conversion to Ang III by aminopeptidase A (APA). Previously, we showed that Ang II and Ang III induced mitogen-activated protein (MAP) kinases ERK1/2 and stress ...
Michelle A. Clark, Chinh Nguyen, Hieu Tran   +2 more
doaj   +1 more source

Activation of G1 Progression, JNK Mitogen-activated Protein Kinase, and Actin Filament Assembly by the Exchange Factor FGD1 [PDF]

Journal of Biological Chemistry, 1998
Cdc42 has been shown to control bifurcating pathways leading to filopodia formation/G1 cell cycle progression and to JNK mitogen-activated protein kinase activation. To dissect these pathways further, the cellular effects induced by a Cdc42 guanine nucleotide exchange factor, FGD1, have been examined.
K, Nagata, M, Driessens, N, Lamarche, J L, Gorski, A, Hall   +4 more
openaire   +2 more sources

Rewiring NADH Metabolism Through NQO1‐Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy

Advanced Science, EarlyView.
ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang, Ziqi Wang, Ye Weng, Yulin Fu, Yuelong Jiang, Beilin Zhuang, Wenzi Zeng, Xiangchun Zhang, Bing Xu, Jie Zha, Hongjun Zhuang   +10 more
wiley   +1 more source

JNK kinase regulates phosphorylation of HCoV-229E nucleocapsid protein

npj Viruses
Identifying common host factors essential for the replication cycles of human coronaviruses (HCoV) could help uncover potential therapeutic targets. Mitogen-activated protein kinases (MAPKs) regulate critical cellular signaling pathways.
Yannick Brüggemann, Toni Luise Meister, Natalie Heinen, Emely Richter, Saskia Westhoven, Michael Poppe, Mohammed Samer Shaban, Leyla Sirkinti, Maximilian Nocke, Daniel Todt, Stephanie Pfaender, Michael Kracht, Eike Steinmann   +12 more
doaj   +1 more source

Stress and Vascular Responses: Mitogen-Activated Protein Kinases and Activator Protein-1 as Promising Therapeutic Targets of Vascular Remodeling

Journal of Pharmacological Sciences, 2003
Mitogen-activated protein kinases (MAP kinases), including extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38, play a central role in cellular responses by various stress stimuli such as cell proliferation, apoptosis ...
Shokei Kim, Hiroshi Iwao
doaj   +1 more source

JNK and p38 mitogen-activated protein kinase pathways contribute to porcine epidemic diarrhea virus infection

Virus Research, 2016
The mitogen-activated protein kinase (MAPK) pathways, which are central building blocks in the intracellular signaling network, are often manipulated by viruses of diverse families to favor their replication. Among the MAPK family, the extracellular signal-regulated kinase (ERK) pathway is known to be modulated during the infection with porcine ...
Lee, Changhee, Kim, Youngnam, Jeon, Ji Hyun   +2 more
openaire   +2 more sources

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Anti-Metastatic and Anti-Inflammatory Effects of Matrix Metalloproteinase Inhibition by Ginsenosides

Biomedicines, 2021
Matrix metalloproteinases (MMPs) are proteolytic enzymes which cleave extracellular matrix (ECM) and other substrates. They are deeply involved in both cancer metastasis and human chronic inflammatory diseases such as osteoarthritis and Crohn’s disease ...
Sang Yeol Lee
doaj   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Effects of Selenium in the MAPK Signaling Cascade [PDF]

Journal of Cardiovascular and Thoracic Research, 2015
Introduction: This study aimed to discover by which mechanism selenium (Se) suppresses stimulated platelets stimulation in oxidative stress underlying diseases.
Nadereh Rashtchizadeh, Pouran Karimi, Parvin Dehgan, Mohamadreza Salimi Movahed   +3 more
doaj   +1 more source