Mitogen activated protein kinase phosphatase 5 alleviates liver ischemia-reperfusion injury by inhibiting TAK1/JNK/p38 pathway [PDF]
, 2023 Qiwen Yu +6 more
openalex +1 more source
The Emphatic Role of Mitogen-Activated Protein Kinases (MAPKs) in the Cellular Mechanisms Mediating Alzheimer's Disease [PDF]
, 2007 Alzheimer's disease (AD) is a neurogenetic condition that affects the processes via which the brain functions. Major observable hallmarks of AD are accumulated clusters of proteins in the brain.
Haddad, John J.
core
Natural products targeting tumour angiogenesis
British Journal of Pharmacology, Volume 182, Issue 10, Page 2094-2136, May 2025.Abstract Tumour angiogenesis is the formation of new blood vessels to support the growth of a tumour. This process is critical for tumour progression and metastasis, making it an attractive approach to cancer therapy. Natural products derived from plants, animals or microorganisms exert anti‐angiogenic properties and can be used to inhibit tumour ...
Xiaohua Lu +2 more
wiley +1 more source
Clinical and Translational Science, Volume 18, Issue 5, May 2025.ABSTRACT Low dose methotrexate (LD‐MTX) remains the gold standard in rheumatoid arthritis (RA) therapy. Multiple mechanisms on a variety of immune cells contribute to the anti‐inflammatory effects of LD‐MTX. Inflammatory signaling is deeply implicated in hematopoiesis by regulating hematopoietic stem and progenitor cell (HSPC) fate decisions; raising ...
Maximilien Lora +5 more
wiley +1 more source
Mechanisms of diabetic cardiomyopathy: Focus on inflammation
Diabetes, Obesity and Metabolism, Volume 27, Issue 5, Page 2326-2338, May 2025.Abstract Purpose of Review Type 2 diabetes (T2D) significantly increases the risk of heart failure (HF), either through the progression of coronary artery disease (CAD) or through direct myocardial alterations, termed diabetic cardiomyopathy. This review examines key pathophysiological mechanisms underlying diabetic cardiomyopathy, focusing on the role
Myriam Bellemare +5 more
wiley +1 more source
Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations [PDF]
arXivThe intrinsic dynamics of most proteins are central to their function. Protein tyrosine kinases such as Abl1 undergo significant conformational changes that modulate their activity in response to different stimuli. These conformational changes constitute a conserved mechanism for self-regulation that dramatically impacts kinases' affinities for ...
arxiv
Host Defense Peptide LL-37-Mediated Chemoattractant Properties, but Not Anti-Inflammatory Cytokine IL-1RA Production, Is Selectively Controlled by Cdc42 Rho GTPase via G Protein-Coupled Receptors and JNK Mitogen-Activated Protein Kinase [PDF]
, 2018 Mahadevappa Hemshekhar +2 more
openalex +1 more source
The FEBS Journal, Volume 292, Issue 9, Page 2173-2188, May 2025.Mitogen‐activated protein kinases (MAPKs) regulate various cellular processes, including proliferation, differentiation, and motility. Alterations in these signalling pathways can lead to various diseases, including cancer. The atypical MAPKs ERK3 (MAPK6), ERK4 (MAPK4), ERK7/8 (MAPK15) and NLK have long been neglected in kinomic studies.
Katrin Dahm +4 more
wiley +1 more source
Molecule Generation for Target Protein Binding with Hierarchical Consistency Diffusion Model [PDF]
arXivEffective generation of molecular structures, or new chemical entities, that bind to target proteins is crucial for lead identification and optimization in drug discovery. Despite advancements in atom- and motif-wise deep learning models for 3D molecular generation, current methods often struggle with validity and reliability.
arxiv
Obesity, white adipose tissue and cancer
The FEBS Journal, Volume 292, Issue 9, Page 2189-2207, May 2025.White adipose tissue (WAT) is essential for energy balance and hormone regulation. In obesity, WAT becomes dysfunctional, leading to inflammation and other changes that promote different stages of carcinogenesis. This review explores how unhealthy WAT under obese conditions supports carcinoma growth through both systemic effects and modulation of the ...
Estel Solsona‐Vilarrasa +1 more
wiley +1 more source