Results 221 to 230 of about 167,044 (343)

Reactive Oxygen Species and Antioxidants in Wound Healing: Mechanisms and Therapeutic Potential

International Wound Journal, Volume 22, Issue 5, May 2025.
ABSTRACT Wound healing is a complex biological process encompassing haemostasis, inflammation, proliferation and matrix remodelling. Reactive oxygen species (ROS) play a pivotal role in regulating key events such as antimicrobial defence, platelet activation and angiogenesis.
Kelechi Ukaegbu, Edward Allen, Kathy K. H. Svoboda   +2 more
wiley   +1 more source

PhosNetVis: a web-based tool for fast kinase-substrate enrichment analysis and interactive 2D/3D network visualizations of phosphoproteomics data [PDF]

arXiv
Protein phosphorylation involves the reversible modification of a protein (substrate) residue by another protein (kinase). Liquid chromatography-mass spectrometry studies are rapidly generating massive protein phosphorylation datasets across multiple conditions.
arxiv  

Protein Biomarkers in Venous Leg Ulcer Fluid: A Systematic Review

International Wound Journal, Volume 22, Issue 5, May 2025.
ABSTRACT Venous leg ulcers (VLUs) are common and cause significant morbidity and poor quality of life. There is a poor understanding of the biology underlying non‐healing VLUs. VLU exudates may reflect the underlying wound microenvironment. This systematic review aims to identify potentially diagnostic and/or prognostic protein biomarkers within VLU ...
Renitha Reddi, Matthew Tan, Alun Huw Davies, Sarah Onida   +3 more
wiley   +1 more source

Activation of c-Jun N-terminal kinase and p38 after cerebral ischemia upregulates cerebral sodium-glucose transporter type 1

Journal of Pharmacological Sciences, 2018
Cerebral ischemic stress increases cerebral sodium-glucose transporter type 1 (SGLT-1). However, the mechanism by which cerebral ischemia leads to the up-regulation of SGLT-1 remains unclear.
Yui Yamazaki, Kyoko Arita, Shinichi Harada, Shogo Tokuyama   +3 more
doaj  

Dual inhibition of TGFβ and PDGF improves RV remodeling and function in response to RV pressure or volume‐loading

Physiological Reports, Volume 13, Issue 9, May 2025.
Abstract Right ventricular (RV) pressure and volume loading induce RV fibrosis in association with RV dysfunction, morbidity, and mortality in repaired tetralogy of Fallot. Transforming‐growth factor‐β1 (TGFβ1) and platelet‐derived growth factor (PDGF) activate common downstream signaling pathways via TGFβ canonical and non‐canonical signaling to ...
John D. Dauz, Kana Yazaki, Yohei Akazawa, Theo A. Meister, Golam Kabir, Sachiko Kadowaki, Osami Honjo, Scott P. Heximer, Rachel M. Wald, Kim A. Connelly, Mark K. Friedberg   +10 more
wiley   +1 more source

Intracellular Sphingosine‐1‐Phosphate Induces Lipolysis Through Direct Activation of Protein Kinase C Zeta

The FASEB Journal, Volume 39, Issue 7, 15 April 2025.
We have identified intracellular S1P as a direct activator of PKC zeta, leading to potent activation of lipolysis in 3T3‐L1 and primary adipocytes in vitro, while inhibition of S1P degradation by blocking S1P lyase through VD‐78 further enhances this effect.
Sarah Weske, Melissa Kim Nowak, Alex Zaufel, Lea Esser, Christoph Peter, Lisa Walz, Helena Kühn, Tsyon Wolde, Julia Hoppe, Nathalie Hannelore Schröder, Tobias Buschmann, Philipp Wollnitzke, Bodo Levkau   +12 more
wiley   +1 more source

Induction of apoptosis and autophagy via regulation of AKT and JNK mitogen-activated protein kinase pathways in breast cancer cell lines exposed to gold nanoparticles loaded with TNF-α and combined with doxorubicin [PDF]

, 2023
Marwa Jawad, Majid S. Jabir, Kamile Öztürk, Ghassan M. Sulaiman, Mosleh M. Abomughaid, Salim Albukhaty, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb, Waleed Khalid Al‐Azzawi, Mazin A. A. Najm, Sabrean F. Jawad   +10 more
openalex   +1 more source

Lipid-soluble cigarette smoking particles induce expression of inflammatory and extracellular-matrix-related genes in rat cerebral arteries

Vascular Health and Risk Management, 2009
Petter Vikman, Cang-Bao Xu, Lars EdvinssonDepartment of Clinical Sciences, Experimental Vascular Research, Lund, SwedenAims: Cigarette smoking is one of the strongest risk factors for stroke.
Petter Vikman, Cang-Bao Xu, Lars Edvinsson   +2 more
doaj  

Protein Kinases as Mediators for miRNA Modulation of Neuropathic Pain. [PDF]

Cells
Chang L, Čok Z, Yu L.
europepmc   +1 more source

Anisomycin Induces Apoptosis of Glucocorticoid Resistant Acute Lymphoblastic Leukemia CEM-C1 Cells via Activation of Mitogen-Activated Protein Kinases p38 and JNK

, 2012
Y Liu, Jiao Ge, Q. LI, Lingkun Gu, Xiaojin Guo, Заседателева М.Г., Yu Zhu   +6 more
openalex   +2 more sources