Results 241 to 250 of about 49,266 (275)

The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs)

International Journal of Biochemistry and Cell Biology, 2001
The c-Jun N-terminal protein kinase mitogen-activated protein kinases (JNK MAPKs) are an evolutionarily-conserved family of serine/threonine protein kinases. First identified in 1990 when intraperitoneal injection of the protein synthesis inhibitor cycloheximide activated a 54 kDa protein kinase, the JNK MAPKs have now taken on a prominent role in ...
Marie A Bogoyevitch
exaly   +3 more sources

The mitogen-activated protein kinases (MAPK) p38 and JNK are markers of tumor progression in breast carcinoma

Gynecologic Oncology, 2006
To investigate the activation of mitogen-activated protein kinases (MAPK) in breast carcinoma effusions and to analyze its relationship to anatomic site and clinical parameters.Activated MAPK (p-ERK, p-JNK, and p-p38) expression was studied in 42 effusions and 51 corresponding solid tumors (23 primary, 28 metastases) using immunohistochemistry (IHC ...
Ben Davidson, Lilach Kleinberg, Assia Bassarova   +2 more
exaly   +3 more sources

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

Science, 1994
Growth factors activate mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs) and Jun kinases (JNKs). Although the signaling cascade from growth factor receptors to ERKs is relatively well understood, the pathway leading to JNK activation is more obscure. Activation of JNK by epidermal growth factor (EGF) or
Audrey Minden, Anning Lin, Martin Mcmahon   +2 more
exaly   +3 more sources

Structure and Expression of Carp Mitogen--Activated Protein Kinases Homologous to Mammalian JNK/SAPK

Journal of Biochemistry, 1997
Two distinct stress-activated protein kinase (JNKa and b) cDNAs were isolated from a carp ovary cDNA library. These cDNAs contained a full-length open reading frame encoding 427 amino acid residues with a predicted mass of 48.6 kDa. The deduced amino acid sequences of JNKa and b were 95.8% identical, with 18 residues replaced, and showed a high degree ...
H, Hashimoto, Y, Matsuo, Y, Yokoyama, H, Toyohara, M, Sakaguchi   +4 more
openaire   +2 more sources

Analyzing JNK and p38 mitogen-activated protein kinase activity

2001
Publisher Summary The JNK and p38 mitogen-activated protein (MAP) kinase groups are important for many physiological processes including cell growth, oncogenic transformation, cell differentiation, apoptosis, and the immune response. To understand the role of JNK and p38 MAP kinases in the cell, several protocols for measuring their activation state ...
Whitmarsh, A. J., Davis, R. J.
openaire   +3 more sources

JNK and ERK mitogen-activated protein kinases mediate THDA-induced apoptosis in K562 cells

Cell Biology and Toxicology, 2007
2-(6-(2-thieanisyl)-3(Z)-hexen-1, 5-diynyl) aniline (THDA), an enediyne compound, was identified in our laboratory as a novel antineoplastic agent against human leukemia K562 cells. THDA-induced apoptosis was associated with the upregulation of Bax, downregulation of X-linked inhibitor of apoptosis (XIAP), as well as the activation of caspase-3 and ...
Sheng-Huei, Yang, Zchong-Zcho, Wu, Ching-Ming, Chien, Yu-Hsiang, Lo, Ming-Jung, Wu, Long-Sen, Chang, Shinne-Ren, Lin   +6 more
openaire   +2 more sources

Phospho-specific mitogen-activated protein kinase antibodies for ERK, JNK, and p38 activation

2001
Publisher Summary The phosphorylation of cellular proteins or enzymes may result in alteration of their conformation and/or their enzyme activity. This is best illustrated by a group of enzymes collectively known as mitogen-activated protein (MAP) kinases, whose dual phosphorylation by upstream protein kinases results in their activation.
S A, Goueli, B W, Jarvis
openaire   +2 more sources

Activation of Mitogen-Activated Protein Kinases (ERK/JNK) and AP-1 Transcription Factor in Rat Carotid Arteries After Balloon Injury

Arteriosclerosis, Thrombosis, and Vascular Biology, 1997
Smooth muscle cell proliferation is a key event in neointimal formation after balloon angioplasty. The molecular signals that mediate this process have yet to be identified.
Qingbo Xu
exaly   +2 more sources

Repeated fasting stress causes activation of mitogen-activated protein kinases (ERK/JNK) in rat liver

Hepatology, 2002
Mitogen-activated protein kinases (MAPK)-signaling pathways play key roles in cytoplasmic-nuclear signal transmission in response to various extracellular stimuli. In this study, we investigated the effect of repeated fasting stress on activation of the 3 members of the MAPK family, the extracellular signal-regulated kinase ...
Hajime, Nishio, Hiroko, Kuwabara, Hiroshi, Mori, Koichi, Suzuki   +3 more
openaire   +2 more sources

Targeting the MKK7–JNK (Mitogen-Activated Protein Kinase Kinase 7–c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors

Journal of Medicinal Chemistry, 2019
The protein kinase MKK7 is linked to neuronal development and the onset of cancer. The field, however, lacks high-quality functional probes that would allow for the dissection of its detailed functions. Against this background, we describe an effective covalent inhibitor of MKK7 based on the pyrazolopyrimidine scaffold.
Patrik Wolle, Julia Hardick, Shane J. F. Cronin, Julian Engel, Matthias Baumann, Jonas Lategahn, Josef M. Penninger, Daniel Rauh   +7 more
openaire   +2 more sources