Results 271 to 280 of about 161,447 (312)

Postconditioning attenuates cardiomyocyte apoptosis via inhibition of JNK and p38 mitogen-activated protein kinase signaling pathways

Apoptosis, 2006
A sequence of intermittent interruptions of oxygen supply (i.e., postconditioning, Postcon) at reoxygenation reduces oxidant-induced cardiomyocyte loss. This study tested the hypothesis that prevention of cardiomyocyte apoptosis by Postcon is mediated by mitogen-activated protein kinases pathways.
He-Ying, Sun, Ning-Ping, Wang, Michael, Halkos, Faraz, Kerendi, Hajime, Kin, Robert A, Guyton, Jakob, Vinten-Johansen, Zhi-Qing, Zhao   +7 more
openaire   +2 more sources

Roles of p38 and JNK mitogen-activated protein kinase pathways during cantharidin-induced apoptosis in U937 cells

Biochemical Pharmacology, 2004
Cantharidin is an active compound from blister beetles traditionally used for the treatment of cancer. It is known to exert its antitumor activity by inducing apoptosis in cancer cells. However, its signaling pathway still remains unclear. Therefore, we investigated the roles of the mitogen-activated protein kinases (MAPKs) and the tumor suppressor ...
Jeong-Eun, Huh, Kyung-Sun, Kang, Chanhee, Chae, Hyung-Min, Kim, Kyoo-Seok, Ahn, Sung-Hoon, Kim   +5 more
openaire   +2 more sources

Effect of c-Jun N-terminal kinase (JNK)/p38 mitogen-activated protein kinase (p38 MAPK) in morphine-induced tau protein hyperphosphorylation

Behavioural Brain Research, 2013
Opioids have been widely used in clinical practice as potent pain relievers for centuries. However, opioids have many deleterious effects. It has been reported that opioid increases tau protein phosphorylation. Hyperphosphorylation of tau is also a pathological feature of Alzheimer's disease and other chronic neurodegenerative disorders.
Minghui, Cao, Funing, Liu, Fengtao, Ji, Jianjun, Liang, Ling, Liu, Qiang, Wu, Tinghuai, Wang   +6 more
openaire   +2 more sources

The mitogen-activated protein kinases (MAPK) p38 and JNK are markers of tumor progression in breast carcinoma

Gynecologic Oncology, 2006
To investigate the activation of mitogen-activated protein kinases (MAPK) in breast carcinoma effusions and to analyze its relationship to anatomic site and clinical parameters.Activated MAPK (p-ERK, p-JNK, and p-p38) expression was studied in 42 effusions and 51 corresponding solid tumors (23 primary, 28 metastases) using immunohistochemistry (IHC ...
Ben, Davidson, Sophya, Konstantinovsky, Lilach, Kleinberg, Mai T P, Nguyen, Assia, Bassarova, Gunnar, Kvalheim, Jahn M, Nesland, Reuven, Reich   +7 more
openaire   +2 more sources

Effect of Ang III on JNK mitogen activated protein (MAP) kinase in Wistar rat VSMCs

The FASEB Journal, 2016
Objective We investigated whether angiotensin (Ang) III induces JNK mitogen activated protein (MAP) kinase protein phosphorylation in isolated rat vascular smooth muscle cells (VSMCs). Moreover, we compared its effect with Ang II. Background
Ahmed Z. Alanazi, Michelle A. Clark
openaire   +1 more source

Mitogen-activated protein kinases p38 and JNK mediate Actinobacillus pleuropneumoniae exotoxin ApxI-induced apoptosis in porcine alveolar macrophages

Veterinary Microbiology, 2011
Actinobacillus pleuropneumoniae exotoxins (Apx) are major virulence factors that play important roles in the pathogenesis of pleuropneumonia in swine. A previous study has demonstrated that native ApxI at low concentrations induces apoptosis in primary porcine alveolar macrophages (PAMs) via a caspase-3-dependent pathway.
Chi-Ming, Wu, Zeng-Weng, Chen, Ter-Hsin, Chen, Jiunn-Wang, Liao, Cheng-Chung, Lin, Maw-Sheng, Chien, Wei-Cheng, Lee, Shih-Ling, Hsuan   +7 more
openaire   +2 more sources

Mitogen‐activated protein kinase (p38‐, JNK‐, ERK‐) activation pattern induced by extracellular and intracellular singlet oxygen and UVA

European Journal of Biochemistry, 1999
Ultraviolet A (UVA; 320–400 nm) radiation in human skin fibroblasts induces a pattern of mitogen‐activated protein kinase (MAPK) activation consisting of a rapid and transient induction of p38 and c‐Jun‐N‐terminal kinase (JNK) activity but not extracellular signal‐regulated kinases (ERK).
L O, Klotz, C, Pellieux, K, Briviba, C, Pierlot, J M, Aubry, H, Sies   +5 more
openaire   +2 more sources

Antimelanogenesis Activity of Hydrolyzed Ginseng Extract (GINST) via Inhibition of JNK Mitogen‐activated Protein Kinase in B16F10 Cells

Journal of Food Science, 2016
Abstract GINST is a hydrolyzed ginseng extract produced by an in vitro process that imitates the metabolic function of bacteria in the human digestive track and has approved by the Ministry of Food and Drug Safety of Korea for the management of postprandial hyperglycemia ...
Joon-Seung, Han, Jong Hwan, Sung, Seung Kwon, Lee   +2 more
openaire   +2 more sources

Mitogen-Activated Protein Kinase Phosphatase-5 is Required for TGF-β Signaling Through a JNK-Dependent Pathway

Molecular and Cellular Biology
Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) constitute members of the dual-specificity family of protein phosphatases that dephosphorylate the MAPKs. MKP-5 dephosphorylates the stress-responsive MAPKs, p38 MAPK and JNK, and has been shown to promote tissue fibrosis.
Sam Dorry, Sravan Perla, Anton M. Bennett   +2 more
openaire   +2 more sources

[The expressions of P38 mitogen-activated protein kinases and JNK mitogen-activated protein kinases in the renal tissue of rats with acute paraquat poisoning and the therapeutical effects of melatonin].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 2015
Xin Wang, Yanxia Zhao, Haixia Li, Shuang Liu, Ying-ping Tian, Ai-qun Li   +5 more
semanticscholar   +1 more source