Results 41 to 50 of about 462,984 (266)
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Il lavoro come atto linguistico e la fine dell’etica convenzionale del lavoro [PDF]
S&F_scienzaefilosofia.it, 2019 Job as a speech act and the end of conventional work Ethics According to the author, the work that takes place in the Cyber Physical System (Smart Factory) has the nature of the «performative speech act».
MARI, GIOVANNI
doaj
La formation en animation socioculturelle en Suisse
Revue Internationale Animation, Territoires et Pratiques Socioculturelles, 2013 Cet article présente et analyse la réalité de la formation en animation socioculturelle en Suisse. Il aborde en premier lieu sa genèse et son évolution pour ensuite réaliser un état des lieux de la situation actuelle de la formation ainsi qu’un détour ...
Yuri Tironi +3 more
doaj +1 more source
EFFECT OF LONELINESS IN THE WORKPLACE ON EMPLOYEES’ JOB PERFORMANCE: A STUDY FOR HOSPITAL EMPLOYEES
International Journal of Health Services Research and Policy, 2019 Loneliness has become one of the most important problems of our time. Loneliness can be seen not only in daily life but also in the workplaces. Loneliness in the workplace has many negative effects on both employees and organizations.
Serkan DENİZ
doaj +1 more source
Jobs, jobs, jobs: what’s an analyst to do?
Monthly Labor Review, 2022 Analysts and economists often face the task of using employment metrics to characterize industries of interest. Some key challenges can be understanding where to find employment metrics, the differences in various employment metrics, and when each metric should be used.
Gavin C. Pickenpaugh, Justin M. Adder
openaire +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Job-to-job transitions, job finding and the ins of unemployment
Labour Economics, 2021 Increases in the ins of unemployment during recessions are the result of two major forces: increased layoffs, or a fall in job finding of potential job-to-job transitions. This paper quantifies the contribution of these two channels using the flows approach to the labour market in the UK and US over a period of two decades.
openaire +2 more sources
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source