Results 61 to 70 of about 725,265 (297)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The Analysis of a Workplace From an Ergonomically Criterion. Case Study: Preliminary Charge

The Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science, 2013
This paper presents a practical method of analyzing a wokplace from an ergonomically criterion based on an "ergonomic analysis questionnaire", and, also, the conclusions and proposed measures in order to improve the activity of the analyzed workplace.
Adrian VASILIU, Marian BORDEI
doaj  

Enhancing Employment Access for People with Disabilities through Transportation: Insights from Workers with Disabilities, Employers, and Transportation Providers

Disabilities
Transportation is integral to the employment accessibility and sustainability of people with disabilities. This study aims to identify barriers, facilitators, and solutions to commuting for people with disabilities, drawing from their perspectives as ...
Alexandra Tessier, Isabelle Gélinas, Normand Boucher, Claire Croteau, Diane Morin, Philippe S. Archambault   +5 more
doaj   +1 more source

Unlocking success: The mediating power of organizational commitment and job satisfaction between work-life balance and employee performance [PDF]

Problems and Perspectives in Management
Work-life balance is crucial in fostering a sense of ownership and achieving company success. When employees can achieve a good balance between work and personal lives, they are more satisfied and have higher organizational commitment. This study aims to
Ni Made Dwi Puspitawati, Ni Putu Cempaka Dharmadewi Atmaja, Ni Putu Lisa Ernawatiningsih, Putu Pradiva Putra Salain, I Putu Wahyu Dwinata JS   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The relationship between psychological capital and job adjustment of staffs in Kermanshah University of Medical Sciences (The study of mediator role of job self-efficacy)

پژوهان, 2018
Background and Objective: Job adjustment as a psychosocial well-being and adaptive state of the individual to post-employment occupation has positive effects, which necessitates identifying the factors that affecting it.
Sohaila Jalilian, Ghaffar Karimianpour
doaj  

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Professional satisfaction among dental practitioners in Ghaziabad city

Journal of Indian Association of Public Health Dentistry, 2015
Introduction: Professional satisfaction is an important determinant of health worker motivation, retention and performance and are critical improving the functioning of health systems in low-and middle income countries. Objective: To measure professional
Venisha Pandita, Basavaraj Patthi, Ashish Singla, Shilpi Singh, Ravneet Malhi, Vaibhav Vashishtha   +5 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

ErgonAir: A quasi-experimental study on the effects of a job specific kinetic training on the musculoskeletal load of airport luggage handlers [PDF]

, 2022
Johann Popp, Jamal Choudhry, Martin Keuchel, Natalie Krämer, Andreas Schäfer, Patrick Serafin, André Klußmann   +6 more
openalex   +1 more source