Results 71 to 80 of about 466,686 (266)

Teaching as a Calling and Well-Being of Slovenian and Croatian Teachers

open access: yesPsychological Topics, 2020
In a sample of 347 elementary school subject teachers from Slovenia (N = 176) and Croatia (N = 171), the authors investigated teachers’ orientations to work (as a job, a career, and a calling) and their well-being with respect to different stages of ...
Polona Gradišek   +3 more
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

The Realizations in Çankırı According to 1844 and 1846 by Dated Chankırı Jizya Books

open access: yesAlınteri sosyal bilimler dergisi, 2018
The Ottoman State gave embezzlement status to these people in order to determine the legal status of non-Muslims. The state of embezzlement is considered by the state as a trust of God and the life, property and honor security of these individuals are ...
Burak KOCAOĞLU
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Comparison of occupation (certain income) and job skills of addiction recovered with return and non-return history

open access: yesمجله علوم روانشناختی, 2021
Background: Numerous studies have been conducted on the role of occupational therapy in the treatment of addicts and the role of job skills in non-return to drug use.
Ali Sheykholeslami   +2 more
doaj  

Impactos socioeconômicos do cultivo de camarão marinho em municípios selecionados do Nordeste brasileiro

open access: yesRevista de Economia e Sociologia Rural, 2008
Neste trabalho, analisa-se o impacto do camarão marinho cultivado sobre a economia de dez municípios selecionados do Nordeste brasileiro. Para tanto, foi desenvolvido o modelo da economia municipal e são usadas matrizes de insumo-produto para calcular os
Yony Sampaio   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

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