Results 81 to 90 of about 4,434,471 (304)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Professional satisfaction among dental practitioners in Ghaziabad city

Journal of Indian Association of Public Health Dentistry, 2015
Introduction: Professional satisfaction is an important determinant of health worker motivation, retention and performance and are critical improving the functioning of health systems in low-and middle income countries. Objective: To measure professional
Venisha Pandita, Basavaraj Patthi, Ashish Singla, Shilpi Singh, Ravneet Malhi, Vaibhav Vashishtha   +5 more
doaj   +1 more source

Why High and Low Performers Leave and What They Find Elsewhere: Job Performance Effects on Employment Transitions [PDF]

, 2007
Little is known about how high and low performers differ in terms of why they leave their jobs, and no work examines whether pre-quit job performance matters for post-quit new-job outcomes. Working with a sample of approximately 2,500 former employees of
Hausknecht , John P., Howard , Michael J., Trevor , Charlie O.   +2 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

THE BOOK OF JOB AS A DEPICTION OF A PERSON’S SPIRITUAL BIRTH PROCESS

Вісник Харківського національного університету імені В.Н. Каразіна. Серія Філософія, філософські перипетії, 2019
The article focuses on the eternal theme of human life: suffering and its cause, deeply revealed in the biblical Book of Job. Although from ancient times this problem and its disclosure were interpreted both in philosophy and in religion, it has remained
Natalya V. Shelkovaya
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Correlation among job-induced stress, overall well-being, and cardiovascular risk in Italian workers of logistics and distribution

Frontiers in Public Health
IntroductionWork-related stress is an occupational risk that has been linked to the development of cardiovascular disease (CVD). While previous studies have explored this association in various work contexts, none have focused specifically on logistics ...
Santo Fruscione, Ginevra Malta, Maria Gabriella Verso, Anna Calascibetta, Daniela Martorana, Emanuele Cannizzaro   +5 more
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

INTERACTION OF UNIVERSITIES AND VENTURE COMPANIES TO PROVIDE EMPLOYMENT AND DEVELOPMENT OF LABOR RELATIONS

Модернизация, инновация, развитие, 2017
The current economic situation is a consequence of the low innovation activity of the real sector. To go to a new quality of the national economy requires the development of venture business segment. However, along with the problem of lack of investment,
A. S. Senin, T. A. Klepova
doaj   +1 more source