Results 81 to 90 of about 466,686 (266)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

PREPARATION OF FUTURE WEB DEVELOPERS TO KNOWLEDGE CERTIFICATION AND EMPLOYMENT IN UNIVERSITIES OF UKRAINE

Ìнформаційні технології в освіті, 2015
One of the main factors of successful employment is a choosing a profession, which would be demanded enough at the modern labour market. According to the opinion of many experts, development of modern technologies is the main factor that stimulates ...
V. Osadchyi, V. Kruglyk
doaj  

Can diabetes be treated as an indirectly work-related disease?

Medycyna Pracy, 2017
In this article the authors attempted to analyze the arguments for considering diabetes as a work-related disease. An overview of literature has been done out of articles published in the years 1980–2016, with the use of combination of key words ...
Andrzej Marcinkiewicz, Anna Radomska, Wojciech Hanke, Jolanta Walusiak-Skorupa   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Exigências nos percursos profissionais de gerentes de banco Demands regarding professional and personal trajectories of bank managers

Psicologia & Sociedade, 2011
Este artigo aborda os percursos de trabalho e formação de gerentes de bancos públicos e privados da cidade de João Pessoa, desde sua inserção até a promoção à função gerencial.
Thaís Augusta Cunha de Oliveira Máximo, Anísio José da Silva Araújo, Paulo César Zambroni-de-Souza, Maria de Fátima Pereira Alberto   +3 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Workplace for individuals in the context of recession [PDF]

Computational Methods in Social Sciences, 2016
Work has been and remains a topic of interest to specialists in the field, but also for labor market actors (bearers of demand and supply, and intermediates).
Mohammad Jaradat, Cicioc Nicoleta, Şerb Diana   +2 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Workability for persons with chronic diseases. A systematic review of validity and utility of assessments in German language / Valide und praktikable deutschsprachige Assessments zur Erfassung der Arbeitsfähigkeit bei Menschen mit chronischen Erkrankungen – eine systematische Review

International Journal of Health Professions, 2018
People with chronic diseases are often limited in their workability. Evaluating and enabling workability is central in rehabilitation. The aim of this study was to evaluate validity and utility of workability assessments in German for persons with ...
Friedli Thomas, Villiger Peter M., Gantschnig Brigitte E.   +2 more
doaj   +1 more source