Results 91 to 100 of about 86,676 (263)

Psychosocial factors at work, long work hours, and obesity: a systematic review

Scandinavian Journal of Work, Environment & Health, 2013
OBJECTIVES: Associations between psychosocial work environment and excess weight have not been systematically addressed. The aim of this systematic review was to summarize the published evidence for the associations of psychosocial factors at work and ...
Svetlana Solovieva, Tea Lallukka, Marianna Virtanen, Eira Viikari-Juntura   +3 more
doaj   +1 more source

Job-demand and family business resources in pandemic context: How they influence burnout and job satisfaction. [PDF]

Front Psychol, 2022
Llanos-Contreras O, Ibáñez MJ, Prado-Gascó VJ.   +2 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Work-related psychosocial factors and working life expectancy among Finnish public sector employees aged 50 years or older

Scandinavian Journal of Work, Environment & Health
OBJECTIVE: This study aimed to examine the associations between work-related psychosocial factors and working life expectancy (WLE) across occupational groups among Finnish public sector employees aged ≥50 years.
Eija Haukka, Katriina Heikkilä, Jaana Pentti, Jussi Vahtera, Holendro Singh Chungkham, Paola Zaninotto, Mika Kivimäki, Jenni Ervasti, Sari Stenholm   +8 more
doaj   +1 more source

When Job Demands Trigger Employee Burnout

Philanthropy: Journal of Psychology
Human resources have an important role in maintaining organizational performance, especially in the competitive retail industry such as PT Ramayana Lestari Sentosa Tbk.
Leoni Monicha Siagian, Sylvia Novarita Ginting, Sri Hartini, Rianda Elvinawanty   +3 more
doaj   +1 more source

Job demands and alcohol use: testing a moderated mediation model

Scandinavian Journal of Work, Environment & Health, 2015
OBJECTIVES: The aim of this two-wave prospective study was to determine how and when job demands are related to alcohol use among employees. By integrating the Job Demands–Control model with the Tension-Reduction theory, we tested a conditional process ...
Morten Birkeland Nielsen, Live Bakke Finne, Jan Olav Christensen, Stein Knardahl   +3 more
doaj   +1 more source

The Impact of Job-Demand-Control-Support on Leptin and Ghrelin as Biomarkers of Stress in Emergency Healthcare Workers. [PDF]

Nutrients, 2022
Bouillon-Minois JB, Outrey J, Pereira B, Adeyemi OJ, Sapin V, Bouvier D, Thivel D, de Saint-Vincent S, Ugbolue UC, Baker JS, Bagheri R, Schmidt J, Trousselard M, Dutheil F.   +13 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The demands–control–support work stress model and risk of ischemic heart disease: causal inference based on observational epidemiology

Scandinavian Journal of Work, Environment & Health
OBJECTIVE: Reviews consistently suggest an association between job strain and ischemic heart disease (IHD), but causality remains uncertain. This study aimed to critically assess causal inference using the most informative epidemiological studies ...
Jens Peter Bonde, Stinna Skaaby, Esben Meulengracht Flachs, Maureen Dollard, Katherine Keyes, Annika Rosengren, Ingrid S Mehlum, Sigurd Mikkelsen   +7 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source