Results 81 to 90 of about 86,676 (263)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

open access: yesFEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Stimulating job demand

open access: yesEuropean Employment Policy Observatory Review, 2014
Viewing the hiring subsidies in the Netherlands over the past decade, there seems to be a constant change in Acts: abolishing existing regulations and introducing new ones. The main measures focus on people at a considerable distance from the labour market, including long-term unemployed welfare recipients and people who have a work disability.
Bekker, S., Wilthagen, L
openaire   +3 more sources

Investigating the Mediating Role of Self-Efficacy in the Relationship between Job Demand and Role Ambiguity with Employee Well-Being

open access: yesمدیریت بهره وری
: Improving the well-being and support of employees will lead to the success of the organization because if the organization supports the employees, they will feel more committed to the organization and will work towards increasing performance and ...
Mahnaz Rahimi   +2 more
doaj  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Enhancing Accuracy in Statistics: Examining Work and Performance in Indonesia's BPS

open access: yesScaffolding: Jurnal Pendidikan Islam dan Multikulturalisme
This study delves into the effects of resilience, job resources, and job demands on the performance of BPS's statistical partners mediated by work engagement.
Sri Yusriani   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Job Demand-Control and Hypertension in African Americans and Non-African Americans. [PDF]

open access: yesJ Occup Environ Med, 2022
Raymond A, Grzywacz JG, Robertson AM.
europepmc   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Development of a European job exposure matrix (EuroJEM) for psychosocial exposures and their association with diagnosed depression in register-based cohorts

open access: yesScandinavian Journal of Work, Environment & Health
OBJECTIVE: This study developed a European job exposure matrix (EuroJEM) for psychosocial work factors in order to examine their prospective associations with diagnosed depression in three register-based Nordic cohorts. METHODS: National, gender-specific
Laura Salonen   +7 more
doaj   +1 more source

Home - About - Disclaimer - Privacy