Results 111 to 120 of about 18,544,393 (301)
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Job quality in European employment policy: one step forward, two steps back?
Transfer - European Review of Labour and Research, 2019 This article analyses the development and use of the concept ‘job quality’ in European Union (EU) employment policy. Using a set of complementary public policy theories, it examines how both political and conceptual factors contributed to the failure to ...
Agnieszka Piasna +2 more
semanticscholar +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Digitalisation, Remote Work, and Perceived Job Security and Quality in Post-COVID-19 Portugal
Administrative SciencesThis study investigates how pandemic-induced digitalisation, understood as the transition to remote work combined with the enforced use of digital tools and the reconfiguration of tasks and digital skills at the job level, has affected job security and ...
Catarina Lucas +5 more
doaj +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Przeglad Socjologii JakosciowejThis article examines the job quality of psychotherapists from the perspective of the sociology of work. Given the increasing demand for mental health services, psychotherapists are classified as ‘essential workers’.
Justyna Zielińska
doaj +1 more source
The Interplay between Education, Skills, and Job Quality
Social Inclusion, 2019 Compared to general education, vocational education and training (VET) has been shown to facilitate young people’s integration into the labour market.
Alexandra Wicht +3 more
semanticscholar +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source