Results 71 to 80 of about 204,896 (305)
Job strain as a risk factor for type 2 diabetes: a pooled analysis of 124,808 men and women. [PDF]
, 2014 OBJECTIVE: The status of psychosocial stress at work as a risk factor for type 2 diabetes is unclear because existing evidence is based on small studies and is subject to confounding by lifestyle factors, such as obesity and physical inactivity.Westerlund, Hugo,, Magnusson Hanson, Linda L, Westerlund, H.,, Ferrie, Jane, E, Nyberg, Solja T, Pejtersen, Jan ,, Nordin, Maria,, Bjorner, J. B.,, Nordin, M.,, Virtanen, M., Steptoe, A., Hanson, L. L. M., Koskinen, A.,, Zins, M.,, Dragano, Nico, Knutsson, Anders,, Westerholm, Peter, J M, Koskenvuo, Markku, Hanson, L. L. M.,, Hamer, M.,, Nielsen, Martin ,, Nielsen, Martin,, Brunner, Eric, J, Nyberg, Solja, T, Madsen, Ida, E H, Magnusson Hanson, Linda ,, Westerholm, Peter,, Magnusson Hanson, Linda,, Brunner, Eric J., Marmot, Michael, G, Väänänen, Ari, Brunner, E. J., Oksanen, T.,, Väänänen, A., Bjorner, J. B., Kouvonen, A., Heikkilä, K.,, Ferrie, J. E.,, Oksanen, Tuula, Marmot, M. G., Theorell, T., Westerlund, Hugo, Pentti, J., Dragano, N., Theorell, Töres,, Burr, Hermann, Leineweber, Constanze, Kouvonen, A.,, Ferrie, Jane,, Batty, G. D.,, Ferrie, J. E., Madsen, Ida,, Theorell, Töres, Knutsson, Anders, Virtanen, Marianna, Salo, Paula, Madsen, Ida E. H., Fransson, Eleonor I.,, Fransson, Eleonor, I, Jokela, Markus, Nordin, Maria, Nyberg, Solja ,, Siegrist, J., Goldberg, M., Leineweber, C., Marmot, Michael G., Vahtera, J.,, Madsen, Ida ,, Suominen, S.,, Hamer, Mark, Vahtera, Jussi, Pejtersen, Jan,, Nyberg, Solja T., Rugulies, Reiner, Pejtersen, Jan, H, Pejtersen, J. H.,, Fransson, E. I.,, Ahola, Kirsi, Koskinen, A., Steptoe, A.,, Borritz, Marianne, Nielsen, Martin L, Bjorner, Jakob,, Fransson, Eleonor,, Brunner, Eric J, Magnusson Hanson, Linda L.,, Fransson, Eleonor I, Fransson, Eleonor I,, Madsen, I. E. H.,, Kouvonen, Anne, Madsen, Ida EH, Pentti, Jaana, Magnusson Hanson, Linda, L, Marmot, M. G.,, Borritz, M.,, Marmot, Michael ,, Singh-Manoux, A., IPD-Work Consortium, Väänänen, A.,, Madsen, Ida E H, Bjorner, Jakob B, Ferrie, Jane E, Pentti, J.,, Bjørner, Jakob, Nyberg, Solja,, Fransson, Eleonor I., Fransson, Eleonor ,, Marmot, Michael G, Westerholm, Peter JM, Batty, G. D., Heikkilä, Katriina, Jokela, M.,, Siegrist, Johannes, Rugulies, R.,, Nyberg, S. T., Westerholm, Peter J M, Alfredsson, L.,, Brunner, Eric ,, Borritz, M., Nielsen, M. L.,, Vahtera, J., Koskenvuo, M.,, Westerholm, Peter J. M., Bjorner, Jakob, B, Batty, G David, Jokela, M., Madsen, I. E. H., Alfredsson, Lars, Bjorner, Jakob B., Ferrie, Jane ,, Nordin, M., Hanson, Linda L. Magnusson, Singh-Manoux, A.,, Zins, Marie, Ferrie, Jane E., Alfredsson, L., Brunner, Eric,, Ahola, K.,, Singh-Manoux, Archana, Salo, P.,, Pejtersen, J. H., Nielsen, Martin L., Pejtersen, Jan H., Brunner, E. J.,, Fransson, E. I., Suominen, S., Dragano, N.,, Goldberg, Marcel, Kivimäki, Mika, Goldberg, M.,, Ahola, K., Westerholm, P. J. M., Hamer, M., Westerlund, H., Rugulies, R., Oksanen, T., Leineweber, Constanze,, Burr, H., Burr, H.,, Marmot, Michael,, Siegrist, J.,, Nyberg, S. T.,, Suominen, Sakari, Kivimäki, M.,, Pejtersen, Jan H, Heikkilä, K., Koskinen, Aki, Koskenvuo, M., Nielsen, M. L., Leineweber, C.,, Nielsen, Martin, L, Steptoe, Andrew, Salo, P., Theorell, T.,, Virtanen, M.,, Westerholm, Peter ,, Westerholm, Peter J. M.,, Batty, G. David, Bjorner, Jakob ,, Zins, M., Kivimäki, M., Westerholm, P. J. M., +181 morecore +1 more sourceA novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz +9 morewiley +1 more sourceJob-related stress and burnout
, 2002 Occupational stress is a topic of substantial interest to organizational researchers and managers, as well as society at large. Stress arising from work conditions can be pervasive and significant in its impact on individuals, their families and ...Cooper, Cary L., O’Driscoll, Michael P. +1 morecore ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach +11 morewiley +1 more sourceJob strain and alcohol intake: a collaborative meta-analysis of individual-participant data from 140,000 men and women. [PDF]
, 2012 The relationship between work-related stress and alcohol intake is uncertain. In order to add to the thus far inconsistent evidence from relatively small studies, we conducted individual-participant meta-analyses of the association between work-related ...Westerlund, Hugo,, Houtman, IL, Magnusson Hanson, Linda L, Goedele A. Geuskens (152461), Theorell, T, Ari Väänänen (152575), Nordin, Maria,, Joensuu Matti, Steptoe, A., Sébastien Bonenfant (152442), Lunau Thorsten, Nyberg, S.T., Markku Koskenvuo (152491), Marmot, Michael, Kittel, F., Hooftman, WE, Lunau, T., Constanze Leineweber, Erbel, R., Borritz Marianne, Michael G Marmot, Hanson Linda L. Magnusson, Suominen, S, Constanze Leineweber (136415), Zins Marie, Ferrie, Jane, Houtman, Irene L., Koskenvuo, M, Jane E Ferrie, Paula Salo (152546), Houtman Irene L., Els Clays, Virtanen, M, Bjorner Jakob B., Ari Väänänen, De Bacquer, D, Joeckel, Karl-Heinz, Jaana Pentti, Karl-Heinz Jöckel (15194), Steptoe, A, Clays, Els, Kouvonen, A., Fransson Eleonor I., Kouvonen Anne, Hermann Burr, Fransson, EI, Dragano, N, Alfredsson, L, Katriina Heikkilä (152434), Thorsten Lunau (152514), Martin L Nielsen, Burr, Hermann, G. David Batty (125073), Kittel, France, Theorell, Töres, Virtanen, Marianna, Martin L. Nielsen (152533), Salo, Paula, G David Batty, Theorell Töres, De Bacquer, Dirk, Vahtera Jussi, Westerlund, H, Siegrist Johannes, Geuskens, GA, Siegrist, J., Anders Knutsson (152485), Matti Joensuu (152473), Ferrie, JE, Goldberg, M., Leineweber, C., Casini, A., Nyberg, Solja, Jaana Pentti (152542), Hooftman, Wendela E., Madsen, Ida, Vahtera, Jussi, Paula Salo, Nyberg, Solja T., Vahtera, J, Mark Hamer, Suominen Sakari, Bonenfant, S., Batty G. David, Erbel, R, Peter Westerholm, Archana Singh-Manoux, Töres Theorell, Westerholm, P., Annalisa Casini, Aki Koskinen, Marianne Borritz (152444), Koskinen, A., Borritz, Marianne, Nielsen, Martin L, Clays Els, Archana Singh-Manoux (152590), Nordin, M, Els Clays (152452), Kivimäki, M, Westerlund Hugo, Leineweber, C, Kouvonen, Anne, IPD Work Consortium, Dirk De Bacquer (20705), Clays, E, Nielsen, M.L., Solja T Nyberg, Bonenfant, Sébastien, Geuskens Goedele A., Bjorner, Jakob B, Nielsen, Martin, Marcel Goldberg, Fransson, Eleonor I., Bjørner, Jakob, Westerholm, Peter, Westerholm Peter, Anders Knutsson, Goedele A Geuskens, Heikkilä, Katriina, Batty, David, Maria Nordin, Westerholm, P, Burr Hermann, Siegrist, Johannes, Dragano Nico, Hermann Burr (152447), Lunau, T, Vahtera, J., Rugulies, R, Eleonor I Fransson, Houtman, Irene, Batty, G David, Alfredsson, Lars, Magnusson Hanson, Linda, Väänänen Ari, Zins, Marie, Ferrie, Jane E., Singh-Manoux, Archana, Eleonor I. Fransson (152438), Suominen, S., Wendela E. Hooftman (152466), Kittel France, Kivimäki, Mika, Karl-Heinz Jöckel, Bjorner, J.B., Erbel, Raimund, Linda L Magnusson Hanson, Maria Nordin (152538), Kivimäki Mika, Houtman, Irene L, Hanson, Linda L Magnusson, Rugulies Reiner, Marcel Goldberg (111570), Markku Koskenvuo, Geuskens, Goedele, Borritz, M, Knutsson, A, Jöckel, KH, Kittel, F, Westerlund, H., Leineweber, Constanze,, Nordin Maria, Sakari Suominen, Ferrie Jane E., Ida E H Madsen, Bjorner, Jakob, Pentti Jaana, Lunau, Thorsten, Koskenvuo, M., Peter Westerholm (152578), Anne Kouvonen (152505), Geuskens, Goedele A, Geuskens, G.A., Joensuu, M, Jöckel, Karl-Heinz, Zins, M., Batty, G.D., Heikkilä Katriina, Nyberg, Solja T, Clays, E., Virtanen, M., Marmot, MG, Dragano, Nico, Nico Dragano (49434), Väänänen, A, Koskenvuo, Markku, Hanson, L.L.M., Salo, P, Johannes Siegrist, France Kittel, Thorsten Lunau, Marianne Borritz, Koskinen Aki, Westerholm, Peter,, Houtman, I.L., Aki Koskinen (152497), Nico Dragano, Marie Zins (111574), Väänänen, Ari, Jakob B Bjorner, Steptoe Andrew, De Bacquer Dirk, Goldberg, M, Väänänen, A., Hooftman, Wendela E, Goldberg Marcel, Marianna Virtanen, Hamer Mark, Koskinen, A, Theorell, T., Raimund Erbel, Westerlund, Hugo, Mark Hamer (145558), Linda L. Magnusson Hanson (152527), Johannes Siegrist (49440), Pentti, J., Dragano, N., Theorell, Töres,, Leineweber, Constanze, Annalisa Casini (152455), Casini Annalisa, Raimund Erbel (49439), Knutsson, Anders, Madsen, Ida E. H., Salo Paula, Fransson, E.I., Nordin, Maria, Marmot, M.G., Reiner Rugulies, Hugo Westerlund, Joensuu, Matti, France Kittel (152480), Sakari Suominen (152560), Dirk De Bacquer, Leineweber Constanze, Casini, Annalisa, Bonenfant Sébastien, Marmot, Michael G., Michael G. Marmot (95285), Madsen, IE, Hamer, Mark, Batty, George David, Mika Kivimäki (95277), Andrew Steptoe, Rugulies, Reiner, Jussi Vahtera (130274), Reiner Rugulies (152550), Nyberg, ST, Singh-Manoux Archana, Batty, GD, Joensuu, M., Jöckel, K.-H., Marmot Michael G., Bonenfant, S, Fransson, Eleonor,, Magnusson Hanson, Linda L.,, Fransson, Eleonor I, Lars Alfredsson, Madsen, Ida EH, Pentti, Jaana, Fransson, Eleonor, Irene L. Houtman (152470), Singh-Manoux, A., IPD-Work Consortium, Jane E. Ferrie (152587), Madsen, Ida E H, Sébastien Bonenfant, Hooftman Wendela E., Ferrie, Jane E, Hooftman, W.E., Marianna Virtanen (152568), Knutsson, A., Töres Theorell (66928), Marmot, Michael G, Knutsson Anders, Hooftman, Wendela, Pentti, J, Magnusson Hanson, LL, Borritz, M., Jussi Vahtera, Alfredsson Lars, Nielsen Martin L., Nielsen, Martin Lindhardt, Bjorner, Jakob B., Ferrie, J.E., Hanson, Linda L. Magnusson, Nordin, M., Alfredsson, L., Nielsen, Martin L., Anne Kouvonen, Goldberg, Marcel, Madsen, I.E.H., Matti Joensuu, Mika Kivimäki, Casini, A, Hamer, M, Nyberg Solja T., Geuskens, Goedele A., Nielsen, ML, Singh-Manoux, A, Hamer, M., Marie Zins, Ida E. H. Madsen (152521), Heikkilä, K, Irene L Houtman, Lars Alfredsson (39207), Erbel Raimund, Rugulies, R., Solja T. Nyberg (152436), Zins, M, Hugo Westerlund (136420), Burr, H., Katriina Heikkilä, Jakob B. Bjorner (152440), Suominen, Sakari, Bjorner, JB, Wendela E Hooftman, Heikkilä, K., Andrew Steptoe (36331), Koskinen, Aki, Madsen Ida E. H., Kouvonen, A, Jöckel Karl-Heinz, Steptoe, Andrew, Koskenvuo Markku, Salo, P., Burr, H, Siegrist, J, Batty, G. David, Bacquer, D. de, Kivimäki, M., Virtanen Marianna +332 morecore +1 more sourceScreening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu +9 morewiley +1 more sourceWhy human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung +3 morewiley +1 more source
