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Mutations in the John Cunningham virus VP1 gene could predispose to the development of progressive multifocal leukoencephalopathy in multiple sclerosis patients undergoing treatment with natalizumab.

Multiple Sclerosis and Related Disorders, 2021
BACKGROUND Patients with Multiple Sclerosis (MS) undergoing treatment with natalizumab (NTZ) are at risk of developing progressive multifocal leukoencephalopathy (PML) due to the reactivation of John Cunningham (JC) virus. A relevant characteristic among
J. Flores   +13 more
semanticscholar   +3 more sources

JCVirusNEntamoebaNET (JCENET): A Deep Neural Network for John Cunningham Virus and Entamoeba Parasite Detection

2021 International Conference on Information and Communication Technology for Sustainable Development (ICICT4SD), 2021
Parasites and viruses are responsible for attacking the immune system of human body and destroying it in the process which makes detection of parasites and virus a penultimate task in modern medical analysis.
M. Hasan, Muhammad Usama Islam
semanticscholar   +2 more sources

Monitoring the John Cunningham virus throughout natalizumab treatment in multiple sclerosis patients

European Journal of Neurology, 2016
Background and purposeProgressive multifocal leukoencephalopathy (PML) cases have arisen amongst multiple sclerosis patients treated with natalizumab. Our objective was to gain a better understanding of the mechanisms that underlie the John Cunningham virus (JCV) infection which causes PML.MethodsA study was made of (i) the quarterly JCV DNA levels in ...
M. Domínguez-Mozo   +9 more
semanticscholar   +3 more sources

John Cunningham virus as cause of progressive multifocal leukoencephalopathy.

Neurologia i Neurochirurgia Polska
T. Wierzba-Bobrowicz   +6 more
semanticscholar   +3 more sources

John Cunningham virus granule cell neuronopathy in a mildly immunosuppressed patient with systemic lupus erythematosus

Internal Medicine Journal, 2019
1 Salvarani C, Cantini F, Hunder GG. Polymyalgia rheumatica and giant-cell arteritis. Lancet 2008; 372: 234–45. 2 Gonzalez-Gay MA, Barros S, LopezDiaz MJ, Garcia-Porrua C, SanchezAndrade A, Llorca J.
Michael Zhong, P. Kempster, T. Phan
semanticscholar   +2 more sources

Detection of Residual Tumor With 68Ga-Pentixafor PET/CT in a Patient With Waldenström Macroglobulinemia and Concurrent John Cunningham Virus-Related Progressive Multifocal Leukoencephalopathy.

Clinical Nuclear Medicine, 2020
A 75-year-old man diagnosed with Waldenström macroglobulinemia (WM) complained of neurological symptoms. Baseline F-FDG PET/CT showed diffusely increased radioactivity in the bone marrow and decreased FDG uptake in the right cerebellum.
Q. Pan, Yaping Luo, M. Qian
semanticscholar   +1 more source

Long-term progressive multifocal leukoencephalopathy risk stratification in multiple sclerosis patients treated with natalizumab with positive John Cunningham virus index.

Neurologia i Neurochirurgia Polska
INTRODUCTION To evaluate the long-term follow-up in patients with multiple sclerosis (MS) with positive John Cunningham virus (JCV) index treated with natalizumab. CLINICAL RATIONALE FOR THE STUDY The prognosis in MS patients with positive JCV index in
Natalia Szejko   +3 more
semanticscholar   +1 more source

Progressive Multifocal Leukoencephalopathy due to John Cunningham (JC) virus following Allogeneic Haematopoietic Cell Transplantation

Antiviral Therapy, 2016
Progressive multifocal leukoencephalopathy (PML) is an uncommon infectious complication post allogeneic stem cell transplant. We present a case report of a patient developing this complication with a review of the current literature. It also describes the first use of artesunate in a clinical case of PML with no beneficial effect.
Wilson, Lam   +9 more
openaire   +2 more sources

Stereotactic brain biopsy of John Cunningham virus-polymerase chain reaction-negative progressive multifocal leukoencephalopathy: a case report

Journal of the Korean Society of Stereotactic and Functional Neurosurgery
Progressive multifocal leukoencephalopathy (PML) is a rare demyelinating disease of the central nervous system caused by ...
S. Ahn   +3 more
semanticscholar   +1 more source

Molekulárně-biologická diagnostika John Cunningham viru z klinického materiálu

2022
JC virus (John Cunningham virus) is one of the polyomaviruses found in humans. Global penetration is estimated at approximately 80 % of the human population. The infection occurs from childhood and does not manifest itself during life. The primary JCV infection is usually asymptomatic.
openaire   +1 more source

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