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Humoral response to John Cunningham virus during pregnancy in multiple sclerosis [PDF]
Multiple Sclerosis and Related Disorders, 2018 Pregnancy induces an immunosuppressive state in the mother to ensure immunological acceptance of the foetus. Impairment of cell-mediated immune responses may render the mother susceptible to intracellular pathogens. It is not presently known whether pregnancy alters the immunosurveillance for John Cunningham virus (JCV), an opportunistic pathogen ...
Maija Saraste
exaly +5 more sources
Seminars in Arthritis and Rheumatism, 2015 The John Cunningham virus (JCV) is a generally benign and asymptomatic polyomavirus. Due to an association of the anti-integrin agent natalizumab with progressive multifocal leukoencephalopathy (PML) in patients with multiple sclerosis (MS), a newly developed anti-JCV antibody assay has been implemented as a risk-stratification tool for natalizumab ...
Joel M Kremer, Dominic Börie
exaly +3 more sources
European Journal of Neurology, 2017 Background and purposeInfection with the John Cunningham virus (JCV) is required for the development of progressive multifocal leukoencephalopathy, the feared complication of natalizumab treatment in multiple sclerosis patients. The JCV seroconversion rate seems higher in natalizumab treated patients than in the normal population, with an unknown cause.
Zoé van Kempen +2 more
exaly +4 more sources
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European Neurology, 2020
Introduction: Presence of anti-JC-virus antibodies (JCVAbs) is associated with the increased risk of natalizumab (NAT)-related progressive multifocal leukoencephalopathy (PML). Little is known about seroconversion rate and time to seroconversion in relapsing-remitting multiple sclerosis (RRMS) patients treated with NAT in Poland.
Katarzyna Kapica-Topczewska +7 more
openaire +2 more sources
Introduction: Presence of anti-JC-virus antibodies (JCVAbs) is associated with the increased risk of natalizumab (NAT)-related progressive multifocal leukoencephalopathy (PML). Little is known about seroconversion rate and time to seroconversion in relapsing-remitting multiple sclerosis (RRMS) patients treated with NAT in Poland.
Katarzyna Kapica-Topczewska +7 more
openaire +2 more sources
JAMA Neurology, 2017
Although seroepidemiological studies indicate that greater than 50% of the population has been infected with John Cunningham virus (JCV), the sites of JCV persistence remain incompletely characterized.To determine sites of JCV persistence in immunologically healthy individuals.Tissue specimens from multiple sites including brain, renal, and nonrenal ...
Joseph R, Berger +12 more
openaire +2 more sources
Although seroepidemiological studies indicate that greater than 50% of the population has been infected with John Cunningham virus (JCV), the sites of JCV persistence remain incompletely characterized.To determine sites of JCV persistence in immunologically healthy individuals.Tissue specimens from multiple sites including brain, renal, and nonrenal ...
Joseph R, Berger +12 more
openaire +2 more sources
Potential of Carcinogenesis Induced by John-Cunningham Virus and Crude-Oil Extracts [PDF]
International Archives of Medical Microbiology, 2018 Lin Shih-Chao +2 more
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2021 International Conference on Information and Communication Technology for Sustainable Development (ICICT4SD), 2021
Parasites and viruses are responsible for attacking the immune system of human body and destroying it in the process which makes detection of parasites and virus a penultimate task in modern medical analysis. The detection process is often characterized with symptoms, microscopic tests.
Md Mahadi Hasan
exaly +2 more sources
Parasites and viruses are responsible for attacking the immune system of human body and destroying it in the process which makes detection of parasites and virus a penultimate task in modern medical analysis. The detection process is often characterized with symptoms, microscopic tests.
Md Mahadi Hasan
exaly +2 more sources