Results 151 to 160 of about 6,272,020 (179)

Monitoring the John Cunningham virus throughout natalizumab treatment in multiple sclerosis patients

European Journal of Neurology, 2015
Background and purposeProgressive multifocal leukoencephalopathy (PML) cases have arisen amongst multiple sclerosis patients treated with natalizumab. Our objective was to gain a better understanding of the mechanisms that underlie the John Cunningham virus (JCV) infection which causes PML.MethodsA study was made of (i) the quarterly JCV DNA levels in ...
M I, Domínguez-Mozo, M, García-Montojo, A, Arias-Leal, Á, García-Martínez, J L, Santiago, I, Casanova, V, Galán, R, Arroyo, M, Fernández-Arquero, R, Alvarez-Lafuente   +9 more
openaire   +2 more sources

Amino Acid Uptake, Glucose Metabolism, and Neuroinflammation in John Cunningham Virus Associated Progressive Multifocal Leukoencephalopathy

Clinical Nuclear Medicine, 2022
Abstract A 69-year-old woman presented with progressive dysarthria and cognitive deficits. On MRI, a T2-hyperintense, non–contrast-enhancing lesion was found in the left precentral area. 18F-FET and 18F-FDG PET scans revealed faint amino acid uptake and glucose hypometabolism of the lesion.
Marcus, Unterrainer, Christoph, Mahler, Adrian-Minh, Schumacher, Viktoria, Ruf, Bernhard, Blum, Stefanie, Quach, Matthias, Brendel, Rainer, Rupprecht, Peter, Bartenstein, Martin, Kerschensteiner, Tania, Kümpfel, Nathalie L, Albert   +11 more
openaire   +2 more sources

Analysis of John Cunningham Virus DNA in Immunosuppressed Patients

2023
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the central nervous system caused by John Cunningham Virus (JCV). JCV is rarely pathogenic in immunocompetent individuals but can reactivate in immunosuppressed patients and cause PML. This study aimed to analyze JCV DNA in immunosuppressed patients by quantitative real-time
KIRCA, Füsun, DİNÇ, Bedia
openaire   +1 more source

Progressive Multifocal Leukoencephalopathy due to John Cunningham (JC) virus following Allogeneic Haematopoietic Cell Transplantation

Antiviral Therapy, 2016
Progressive multifocal leukoencephalopathy (PML) is an uncommon infectious complication post allogeneic stem cell transplant. We present a case report of a patient developing this complication with a review of the current literature. It also describes the first use of artesunate in a clinical case of PML with no beneficial effect.
Wilson, Lam, Zeyad, Al-Shaibani, Deepali, Kumar, Auro, Viswabandya, Santhosh, Thyagu, Fotios V, Michelis, Dennis Dong-Hwan, Kim, Jeffrey H, Lipton, Hans A, Messner, Uday, Deotare   +9 more
openaire   +2 more sources

Molekulárně-biologická diagnostika John Cunningham viru z klinického materiálu

2022
JC virus (John Cunningham virus) is one of the polyomaviruses found in humans. Global penetration is estimated at approximately 80 % of the human population. The infection occurs from childhood and does not manifest itself during life. The primary JCV infection is usually asymptomatic.
openaire   +1 more source

John Cunningham Virus (JCV) in Renal Allograft Recipients (RAR)

Journal of the American Society of Nephrology, 2020
Bushra Z. Saleem, Sonika Puri, Zahidul H. Mondal   +2 more
openaire   +1 more source

John Cunningham virus: an overview on biology and disease of the etiological agent of the progressive multifocal leukoencephalopathy.

The new microbiologica, 2018
John Cunningham virus (JCV), the etiological agent of progressive multifocal leukoencephalopathy (PML), is the first human polyomavirus described. After asymptomatic primary infection which occurs in childhood, the virus spreads by the hematogenous route from the primary site of infection to secondary sites including kidneys, lymphoid tissues ...
Pietropaolo V, Prezioso C, BAGNATO, FRANCESCA ROSARIA, Antonelli G   +3 more
openaire   +2 more sources

Anti-John Cunningham Virus antibody prevalence in multiple sclerosis patients in Turkey

2013
Exposure to John Cunningham Virus (JCV) has been associated with Progressive Multifocal Leukoencephalopathy (PML) in Multiple Sclerosis (MS) patients under specific treatments. In order to assess the identifiable risks of Turkish relapsing-remitting multiple sclerosis (RRMS) patients, the seroprevalence rate of JCV antibodies was investigated and ...
ERAKSOY, Mefkure, AGAN, Kadriye, AK, Fikri, ANLAR, Omer, BALCI, Belgin, BOZ, Cavit, CELIK, Yahya, DEMIRKAYA, Seref, EFENDI, Husnu, GECIZLIOGLU, Muhtesem, GUNAL, Dilek, AYDIN GUNGOR, Hulya, ISIK, Nihal, IDILMAN, Egemen, KARABUDAK, Rana, KURNE, Aslı, NEYAL, Munife, OZAKBAS, Serkan, EKMEKCI OZBAY, Ozgul, OZCAN, Cemal, OZTEKIN, Nese, OZTURK, Musa, SAIP, Sabahattin, SIVA, Aksel, SOYSAL, Aysun, TASKAPILIOGLU, Ozlem, TERZI, Murat, TURAN, Omer, TURKOGLU, Recai, YUCEMEN, Nezih, YUCEYAR, Ayse, ZORLU, Yasar, ULKU, Cunay, DIB, Huseyin, UREN, Deniz   +34 more
openaire   +1 more source

The effect of tonsillectomy on John Cunningham virus serological status in multiple sclerosis patients: A retrospective case–control study

Multiple Sclerosis Journal, 2021
Mirla Avila, Smathorn Thakolwiboon, Annette Okai   +2 more
exaly  

Mutations in the John Cunningham virus VP1 gene could predispose to the development of progressive multifocal leukoencephalopathy in multiple sclerosis patients undergoing treatment with natalizumab

Multiple Sclerosis and Related Disorders, 2021
Veronica Rivas-Alonso, G Ordonez, J Flores   +2 more
exaly