Results 21 to 30 of about 97,726 (142)

Low natalizumab trough concentrations are associated with reduced seroconversion of the John Cunningham virus in natalizumab-treated patients with multiple sclerosis. [PDF]

J Neurol Neurosurg Psychiatry
Background Natalizumab is a highly effective drug for patients with relapsing-remitting multiple sclerosis (MS). A disadvantage of this treatment is the risk of progressive multifocal leukoencephalopathy in patients who are seropositive for the John ...
Gelissen LMY, Toorop AA, Schipper PM, Hoitsma E, Zeinstra EMPE, van Rooij LC, van Munster CEP, Vennegoor A, Mostert J, Wokke B, Kalkers NF, Hoogervorst ELJ, van Eijk J, Roosendaal CM, Kragt JJ, Eurelings M, van Genugten J, Nielsen J, Sinnige LGF, Kloosterziel ME, Arnoldus EPJ, Bouvy WH, Strijbis EM, Oosten BV, De Jong BA, Uitdehaag BMJ, Lissenberg-Witte BI, Loeff FC, Rispens T, Killestein J, van Kempen ZLE.   +30 more
europepmc   +2 more sources

Anti-John Cunningham virus antibody index levels in multiple sclerosis patients treated with rituximab, fingolimod, and dimethyl fumarate. [PDF]

Surg Neurol Int, 2019
Background: Progressive multifocal leukoencephalopathy (PML), a potentially fatal demyelinating disease caused by the John Cunningham virus (JCV), can occur as a complication of treatment with rituximab, fingolimod, and dimethyl fumarate.
Farley S, Gottesman MH, Friedman-Urevich S, Ye J, Shen M, Grueneberg D, Martone L, Calixte R.   +7 more
europepmc   +2 more sources

Systematic review of the published data on the worldwide prevalence of John Cunningham virus in patients with multiple sclerosis and neuromyelitis optica. [PDF]

Epidemiol Health, 2018
OBJECTIVES John Cunningham virus (JCV) is a polyoma virus that infects humans, mainly in childhood or adolescence, and presents no symptomatic manifestations. JCV can cause progressive multifocal leukoencephalopathy (PML) in immunosuppressed individuals,
Paz SPC, Branco L, Pereira MAC, Spessotto C, Fragoso YD.   +4 more
europepmc   +2 more sources

"Pardon My Language": The Curious Case of a Bloody Sandwich and the John Cunningham Virus Reactivation in the Era of Immunomodulatory Drugs. [PDF]

Cureus
Progressive multifocal leukoencephalopathy (PML) is a rare diagnosis associated with high mortality in different clinical settings. PML has been attributed to the reactivation of the John Cunningham (JC) virus (JCV).
Guerra-Bauman F, Tseng JE, Latif A, Cohan C, Assalita J, Waheed A.   +5 more
europepmc   +2 more sources

Viruria of Human BK Virus and John Cunningham Virus among Renal Transplant Recipients and Healthy Control in Southeast of Caspian Sea [PDF]

Intervirology, 2021
Background: Members of the Polyomaviridae family, BK virus (BKV), and John Cunningham virus (JCV) are linked to polyomavirus-associated nephropathy-associated transplant rejection in immunodeficient patients.
F. Safaei, Alireza Mohebbi, Mina Hassanpour, Hadi Razavi Nikoo, A. Tabarraei   +4 more
semanticscholar   +3 more sources

The Incidence and Predisposing Factors of John Cunningham Virus-Induced Progressive Multifocal Leukoencephalopathy in Southern Finland: A Population-Based Study. [PDF]

Open Forum Infect Dis, 2019
This is an observational study of PML cases during 2004-2016 where each case was identified and verified by clinical data by several specialties and biomarkers. Better safety protocols are recommended for all PML related medications.
Kartau M, Verkkoniemi-Ahola A, Paetau A, Palomäki M, Janes R, Ristola M, Lappalainen M, Anttila VJ.   +7 more
europepmc   +2 more sources

A case of recurrent progressive multifocal leukoencephalopathy after human stem cell transplant, with detection of John Cunningham virus and human herpesvirus 6 on cerebrospinal fluid, treated with Mirtazapine, Olanzapine and Foscarnet. [PDF]

Intractable Rare Dis Res, 2019
We reported the case of a John Cunningham virus (JCV) and human herpesvirus 6 (HHV-6) mediated progressive multifocal leukoencephalopathy (PML) after human stem cell transplant, reactivated 6 months later in absence of immunosuppressive therapy ...
Pasca M, Picchioni A, Mazzeo S, Terenzi F, Prestipino E, Fratangelo R, Repice AM, Carlucci G, Massacesi L, Barilaro A.   +9 more
europepmc   +2 more sources

Analysis of John Cunningham Virus DNA in Immunosuppressed Patients

Gümüşhane üniversitesi sağlık bilimleri dergisi, 2023
Progresif multifokal lökoensefalopati (PML), John Cunningham Virüsünün (JCV) etken olduğu merkezi sinir sisteminin demiyelinizan bir hastalığıdır. İmmünkompetan bireylerde JCV nadiren patojeniktir, ancak immünsuprese hastalarda reaktive olarak PML’ye ...
Füsun Kırca, B. Dinç
semanticscholar   +3 more sources

John Cunningham Virus Status, Seroconversion Rate, and the Risk of Progressive Multifocal Leukoencephalopathy in Polish John Cunningham Virus-Seronegative Patients with Relapsing-Remitting Multiple Sclerosis

European Neurology, 2020
Introduction: Presence of anti-JC-virus antibodies (JCVAbs) is associated with the increased risk of natalizumab (NAT)-related progressive multifocal leukoencephalopathy (PML).
K. Kapica-Topczewska, F. Collin, J. Tarasiuk, Agata Czarnowska, M. Chorąży, A. Mirończuk, J. Kochanowicz, A. Kułakowska   +7 more
semanticscholar   +3 more sources

BK and JC polyomavirus co-infection resulting in polyomavirus nephropathy and progressive multifocal leukoencephalopathy at the same time, a case report [PDF]

Brazilian Journal of Infectious Diseases
John Cunningham Virus (JCV) and BK Virus (BKV) are the most extensively studied Human Polyomaviruses (HPyVs), primarily associated with Progressive Multifocal Leukoencephalopathy (PML) and BKV Nephropathy (BKVN), respectively.
Sébastien Briol, Laura Labriola, Arnaud Devresse, Benoit Kabamba, Valeria Onofrj, Leïla Belkhir   +5 more
doaj   +2 more sources