Results 51 to 60 of about 5,814 (145)

Safety and Effectiveness of Dimethyl Fumarate in Japanese Patients With Multiple Sclerosis: 2‐Year Post‐Marketing Surveillance Data

Neurology and Clinical Neuroscience, Volume 14, Issue 1, Page 54-68, January 2026.
ABSTRACT Background Dimethyl fumarate (DMF) is an orally administered disease‐modifying drug used for the treatment of multiple sclerosis (MS) in numerous countries worldwide. Aim An ongoing post‐marketing surveillance (PMS) is assessing the real‐world safety and effectiveness of DMF in Japanese patients with MS.
Hirofumi Ochi, Toshiyuki Fukazawa, Takashi Yamamura, Kazumasa Yokoyama, Takashi Ohashi, Ichiro Nakashima, Masanori Mizuno, Hikoaki Fukaura, Izumi Kawachi, Tatsusada Okuno, Ryusuke Sato, Haruki Makioka, Aya Tsuchiya, Michihiro Kanda, Yayoi Sato, Takahiko Saida   +15 more
wiley   +1 more source

JC Virus and APOL1 Risk Alleles in Black South Africans With Hypertension-Attributed CKD

Kidney International Reports, 2019
Introduction: The polyomaviruses, John Cunningham (JC) and BK, infect humans, with primary infection occurring in childhood. First-degree relatives of African American individuals with nondiabetic chronic kidney disease (CKD) who had 2 apolipoprotein L1 (
Nolubabalo U. Nqebelele, Caroline Dickens, Therese Dix-Peek, Raquel Duarte, Saraladevi Naicker   +4 more
doaj   +1 more source

Progressive multifocal leukoencephalopathy after durvalumab treatment for acute myeloid leukemia: A consequence of an immune reconstitution inflammatory syndrome?

eJHaem, 2022
Progressive multifocal leukoencephalopathy (PML) is a fatal demyelinating disease of the central nervous system resulting from the reactivation of the John Cunningham virus (JCV).
Emeline Vinatier, Caroline Poli, Aurélien Giltat, Christopher Nunes‐Gomes, Corentin Orvain, Mathilde Hunault‐Berger, Pascale Jeannin, Sylvain Thépot   +7 more
doaj   +1 more source

VIRUS DE JOHN CUNNINGHAM: ¿TRANSEÚNTE INOFENSIVO O ASESINO SILENCIOSO? REVISIÓN SOBRE SU ROL PATÓGENO EN LA LEUCOENCEFALOPATÍA MULTIFOCAL PROGRESIVA. RECORRIDO TEÓRICO HACIA LA CAUSALIDAD

Revistas Argentina de Medicina, 2022
La leucoencefalopatía multifocal progresiva (LMP), cuya incidencia creció con la pandemia del virus de inmunodeficiencia humana (VIH), aún no cuenta con tratamientos específicos y requiere la resolución del inmunocompromiso subyacente para la mejoría ...
Maximiliano Castro
doaj   +2 more sources

Advances in pancreatic cancer early diagnosis, prevention, and treatment: The past, the present, and the future

CA: A Cancer Journal for Clinicians, Volume 76, Issue 1, January/February 2026.
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a dismal prognosis, largely because of late‐stage diagnosis and therapeutic resistance. PDAC incidence has been rising, with modifiable and non‐modifiable risk factors contributing to disease development.
Alessandro Mannucci, Ajay Goel
wiley   +1 more source

Diagnostic difficulties in progressive multifocal leukoencephalopathy: a case report

Folia Neuropathologica
Progressive multifocal leukoencephalopathy (PML) is a demyelination disease of the central nervous system (CNS) caused by viral infection with John Cunningham polyomavirus (JC virus, JCV). PML affects mainly patients with immunodeficiency.
Angelika Stapińska-Syniec, Michał Sobstyl, Katarzyna Kurowska, Albert Acewicz, Teresa Wierzba-Bobrowicz   +4 more
doaj   +1 more source

LINE‐1 Retroelement Activation and Neuroinflammation in Persons With Fanconi Anemia

Pediatric Blood &Cancer, Volume 72, Issue 12, December 2025.
ABSTRACT We describe the first immunohistochemical analysis performed on brain lesion biopsies from two young individuals with Fanconi anemia neuroinflammatory syndrome (FANS). We identified aberrant activation of the LINE‐1 retrotransposon as a novel mechanism of neuroinflammation in individuals with hematological disorders.
Allison L. Bartlett, Kristie N. Ramos, Jamen R. Bartlett, Kenneth S. Ramos, Nathan Luebbering, Kasiani C. Myers, Parinda A. Mehta, Stella M. Davies   +7 more
wiley   +1 more source

Soil‐borne fungal diseases in Aotearoa New Zealand pastures: a significant research blind spot

New Zealand Journal of Agricultural Research, Volume 68, Issue 6, Page 1288-1310, December 2025.
ABSTRACT In Aotearoa New Zealand (AoNZ), where pastoral agriculture is vital to the economy, reports of pasture plant species failing to persist in long‐term pastures, particularly in northern regions, are increasingly common. The underlying cause of this decline in pasture persistence remains elusive.
Sarah A. M. van Amsterdam, Matthew D. Templeton, Gavin Lear, Nigel L. Bell   +3 more
wiley   +1 more source

Commodity risk assessment of Castanea sativa plants from the United Kingdom

EFSA Journal, Volume 23, Issue 12, December 2025.
Abstract The European Commission requested the EFSA Panel on Plant Health to prepare and deliver risk assessments for commodities listed in Commission Implementing Regulation (EU) 2018/2019 as ‘High risk plants, plant products and other objects’. This Scientific Opinion covers plant health risks posed by graftwood, whips, bare root plants and potted ...
EFSA Panel on Plant Health (PLH), Antonio Vicent Civera, Paula Baptista, Elisavet Chatzivassiliou, Jaime Cubero, Nik Cunniffe, Eduardo de la Peña, Nicolas Desneux, Anna Filipiak, Paolo Gonthier, Beata Hasiów‐Jaroszewska, Hervé Jactel, Blanca B. Landa, Lara Maistrello, David Makowski, Panagiotis Milonas, Nikos T. Papadopoulos, Roel Potting, Hanna Susi, Dirk Jan van der Gaag, Pedro Gómez, Annemarie Fejer Justesen, Andrea Lucchi, Gregor Urek, Jonathan Yuen, Lucia Zappala, Umberto Bernardo, Giovanni Bubici, Anna Vittoria Carluccio, Michela Chiumenti, Francesco Di Serio, Elena Fanelli, Paraskevi Kariampa, Cristina Marzachì, Agata Kaczmarek, Louise Matic, Dora Mijic, Olaf Mosbach‐Schulz, Anna Berlin   +38 more
wiley   +1 more source

Progressive multifocal leukoencephalopathy in a patient without apparent immunosuppression

Virology Journal, 2010
An 80-year-old man with no history of an immune-compromising disorder was diagnosed with progressive multifocal leukoencephalopathy (PML). He presented with dysphagia and left-sided weakness; magnetic resonance imaging demonstrated marked signal ...
Escobar Miguel A, Lovy Jordan, Sotelo-Rafiq Elsa P, Vaklavas Christos, Tsimberidou Apostolia M   +4 more
doaj   +1 more source