Results 81 to 90 of about 852,963 (281)
Constructing Optimal Bushy Processing Trees for Join Queries is NP-hard [PDF]
, 1996 We show that constructing optimal bushy processing trees for join queriesis NP-hard. More specifically, we show that even the construction of optimal bushy trees for computing the cross product for a set of relations is NP ...
Moerkotte, Guido, Scheufele, Wolfgang
core
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The irregularity of graphs under graph operations
Discussiones Mathematicae Graph Theory, 2014 The irregularity of a simple undirected graph G was defined by Albertson [5] as irr(G) = ∑uv∈E(G) |dG(u) − dG(v)|, where dG(u) denotes the degree of a vertex u ∈ V (G).
Abdo Hosam, Dimitrov Darko
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Crossing number of Cartesian product of prism and path
AKCE International Journal of Graphs and Combinatorics, 2020 An m-prism is the Cartesian product of an m-cycle and a path with 2 vertices. We prove that the crossing number of the join of an m-prism () and a graph with k isolated vertices is km for each We then use this result to prove that the crossing number of ...
Yip C. Yiew, Gek L. Chia, Poh-Hwa Ong
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
On Sequentially Cohen-Macaulay Complexes and Posets
, 2007 The classes of sequentially Cohen-Macaulay and sequentially homotopy Cohen-Macaulay complexes and posets are studied. First, some different versions of the definitions are discussed and the homotopy type is determined.
Björner, Anders +2 more
core +2 more sources
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Influencing the mechanical properties of pre-JOINED hybrid semi-finished products by impact extrusion [PDF]
, 2023 A. PIWEK +3 more
openalex +1 more source
FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source