Results 41 to 50 of about 436,548 (250)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A Study on the Bond Strength of Plastic–Metal Direct Bonds Using Friction Press Joining

, 2021
Friction press joining (FPJ) is an innovative joining process for bonding plastic components and metal sheets without additives in an overlap configuration. This paper focuses on the resulting bond strength.
Maren T. Herold, Stefan P. Meyer, Jan B. Habedank, Michael F. Zaeh   +3 more
core   +1 more source

The effect of temperature and joining speed on the joining quality for conduction laser joining of metals to polymers [PDF]

, 2021
Laser joining of metals to polymers offers several advantages to produce lightweight hybrid assemblies. An important one is the exceptional control over the heat input which defines the temperature at the interface of the materials.
PLAPPER, Peter, Hennico, Max, AMNE ELAHI, Mahdi   +2 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Joining of Metal to Ceramic Plate Using Super-Spread Wetting

, 2020
Ceramic-metal composites with novel performance are desirable materials; however, differences in their properties result in difficulties in joining. In this study, the joining of metal to ceramic is investigated.
Masashi Nakamoto, Jaebong Yeon, Toshihiro Tanaka, Michiru Yamamoto, Peiyuan Ni   +4 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Triple joining of different sheets with self-pierce riveting method

, 2022
Self-piercing riveting (SPR) is a high-speed mechanical joining technique for sheet metal materials. In this study, the mechanical properties of DC04 steel and AA5182 aluminium alloy in triple combinations joined by the SPR method were investigated.
Bakırcı, A., Dinkçi, H., Çavuşoğlu, Oktay, Yılmazoğlu, A. G.   +3 more
core   +2 more sources

Glass–ceramic joining of duplex SiCf/SiC cladding tubes by localized rapid heating and its interfacial hydrothermal corrosion behavior

Journal of Advanced Ceramics
SiCf/SiC cladding tubes were joined to end plugs using Y2O3–Al2O3–SiO2 (YAS) glass filler through localized rapid induction heating at 1400–1500 °C. The joint fabricated at 1450 °C exhibited a dense and uniform glass–ceramic interlayer with the highest ...
Chuang-Tian Zhan, Kun-Heng Huang, Jia-Pei Chen, Qu Ai, Yu Tian, Li-Xiang Wu, Yun Li, Wei-Ming Guo, Yang Liu, Rong-Kun Yang, Jia-Xiang Xue, Hua-Tay Lin   +11 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source