Results 71 to 80 of about 436,548 (250)

Laser joining

334Joining with laser radiation is a technology that has long been industrially established for joining a wide variety of materials. Primarily materials of the same type are joined by melting processes with and without additive material supply by local ...
Olowinsky., Alexander M., Gillner, Arnold, Petring, Dirk   +2 more
core   +1 more source

WHOM THE SOVEREIGN EMPEROR HIS MAJESTY OF RUSSIA HAS DEIGNED TO ACCEPT ON MAY 19, 1881 EXACTLY AT ONE O’CLOCK P.M

Неофилология, 2017
The questions connected with joining of the Turkmen earths to the Russian empire are considered, namely those armed events which occurred in 1879 and 1881 under command of Russian generals on the one hand and leaders of a Turkmen home guard on the other ...
Muradgeldi Soyegov
doaj  

A review on solid riveting techniques in aircraft assembling

Manufacturing Review, 2020
Solid riveting is the most widely used joining technique in aircraft assembly, and the current key problems affecting practical application and reliable lifting are concentrated on static strength and fatigue.
Zhao Hongwei, Xi Jiangjing, Zheng Kailun, Shi Zhusheng, Lin Jianguo, Nikbin Kamran, Duan Shihui, Wang Binwen   +7 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Innovative Surface Treatment Techniques for Carbon Fiber-Based Polymer Matrix Composites

Solids
Adhesive bonding has emerged as a promising technology for joining carbon fiber reinforced polymer (CFRP) structures in aircraft, offering advantages over traditional mechanical fastening such as weight reduction and uniform stress distribution.
Mehmet Erdem Iris, Metin Tanoglu, Elmas Salamci, Serkan Dehneliler, Hande Iplikci, Gozde Esenoglu   +5 more
doaj   +1 more source

Integration of multiple-linear and tumbling kinematics into self-piercing riveting [PDF]

MATEC Web of Conferences
Conventional mechanical joining processes are typically rigid in their tool systems and can only react to changing process and disturbance variables to a limited extent.
Holtkamp Pia, Wituschek Simon, Lechner Michael, Meschut Gerson   +3 more
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Investigation failure behavior in the shear tensile test with variety of specimen stiffness [PDF]

MATEC Web of Conferences
This paper focuses on the failure behavior of clinched specimens with various stiffnesses under shear tensile loading. The primary objective is to assess the influence of the specimen stiffness with an arrangement of clinched joints.
Wolf Eugen, Brosius Alexander
doaj   +1 more source