Results 51 to 60 of about 2,997,799 (357)

Fire resistance of steel beam to square CFST column composite joints using RC slabs: Experiments and numerical studies [PDF]

open access: yes, 2019
In this paper, experimental investigation and numerical simulation of steel beam to square concrete-filled steel tube (CFST) column composite joints that use reinforced concrete (RC) slabs subjected to localized and global fire conditions are presented ...
Fu, F., Yang, Y-F.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The Beneficial Effect of Praeruptorin C on Osteoporotic Bone in Ovariectomized Mice via Suppression of Osteoclast Formation and Bone Resorption

open access: yesFrontiers in Pharmacology, 2017
Being a highly prevalent disease, osteoporosis causes metabolism defects. Low bone density, compromised bone strength, and an increased danger of fragility fracture are its main characteristics.
Xuqiang Liu   +9 more
doaj   +1 more source

Active joints for microrobot limbs [PDF]

open access: yes, 1992
The authors propose an electrostatic actuator for active joints. The active joint consists of two plates, one of which is a bilayer and bent by the bimorph effect. The plates are clamped to each other at one edge.
Elwenspoek, M., Hok, B., Smith, L.
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

FMEA of gasketed and non-gasketed bolted flanged pipe joints [PDF]

open access: yes, 2005
Limited work is available in the literature on the Failure Mode and Effects Analysis of bolted flanged pipe joints. From previous comparative reliability studies of both gasketed and non-gasketed bolted flanged pipe joints, generally it is found that ...
Abid, Muhammad, Nash, David
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Research on the Electric Field Distribution and Structure Optimizing  of Integral Prefabricated Joint and Taped Joint

open access: yesJournal of Harbin University of Science and Technology, 2018
Integral prefabricated joint and taped joint are two kinds of widely used cable joint.Because of the different structure and conductivity of insulation, there is great difference in the electric field distribution between the two kinds of joints .In this
CHEN Zhen-xin   +7 more
doaj   +1 more source

Design and analysis of joints between light composite superstructure and steel hull

open access: yesZhongguo Jianchuan Yanjiu, 2020
[Objectives] Designing effective and reliable composite and steel joints is one of the difficulties faced in the application of composite superstructure in ships.[Methods] Considering the advantages and disadvantages of various joint structures,the π ...
LI Han, GUO Zhanyi
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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