Results 61 to 70 of about 2,997,799 (357)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Using deep networks for knee range of motion monitoring in total knee arthroplasty rehabilitation

Frontiers in Bioengineering and Biotechnology
BackgroundKnee range of motion (ROM) is a key indicator of rehabilitation after total knee arthroplasty (TKA). Current tools, such as visual and protractor measurements, are cumbersome, imprecise, and require professional training, limiting their use in ...
Yi-Xiang Zhang, Yi-Xiang Zhang, Qiu-Yu Wang, Tao Yang, Tao Yang, Jia-He Wang, Hao-Tian Yin, Hao-Tian Yin, Lei Wang, Jun Liu, Jun Liu   +10 more
doaj   +1 more source

Quantitative sensory testing in painful hand osteoarthritis demonstrates features of peripheral sensitisation. [PDF]

, 2012
Hand osteoarthritis (HOA) is a prevalent condition for which treatments are based on analgesia and physical therapies. Our primary objective was to evaluate pain perception in participants with HOA by assessing the characteristics of nodal involvement ...
Ejindu, V, Hermansson, M, Heron, C, Kiely, P, Sofat, N, Wajed, J   +5 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Glaucocalyxin A delays the progression of OA by inhibiting NF-κB and MAPK signaling pathways

Journal of Orthopaedic Surgery and Research
Background Osteoarthritis (OA) is a common degenerative joint condition marked by inflammation and cartilage breakdown. Currently, there is a dearth of treatment medications that can clearly slow the course of OA.
Xin Hong, Xuqiang Liu, Bo Li, Shoujie Shi, Kai Xiao, Tiantian Xu, Yaoyang Nie, Min Dai, Meisong Zhu   +8 more
doaj   +1 more source

Videos in short-video sharing platforms as sources of information on osteoarthritis: cross-sectional content analysis study

Frontiers in Digital Health
BackgroundOsteoarthritis (OA) is a debilitating condition characterized by pain, stiffness, and impaired mobility, significantly affecting patients' quality of life. Health education is crucial in helping individuals understand OA and its management.
Yi-xiang Zhang, Yi-xiang Zhang, Hao-tian Yin, Hao-tian Yin, Ya-xing Liu, Ya-xing Liu, Xin Fu, Jun Liu, Jun Liu, Jun Liu   +9 more
doaj   +1 more source

Corrosion Properties of Various Copper Pipes Joints

Communications, 2014
The paper presents the experimental results of various Cu pipes joint corrosion behavior. Joining of copper pipes used for liquid media transport can be made as demountable and fixed joints.
Tatiana Liptakova, Monika Halamova, Ayman Alaskari, Martin Lovisek, Maxim Puchnin   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Modelling of timber joints in traditional structures [PDF]

, 2006
Original unstrengthened timber connections and the effects of different strengthening techniques have been evaluated experimentally with tests on full-scale birdsmouth joints.
Branco, J., Cruz, P., Piazza, M., Varum, H.   +3 more
core   +1 more source

Stress distribution of secondary bending in single-lap bolted joints with dissimilar joining plates and plate types [PDF]

, 2016
Single-lap joints are an important class of bolted joint in the aerospace and civil engineering sectors. This type of joint is preferred as it can reduce weight and hence help to optimize fuel efficiency.
Ahmad, Hilton
core   +1 more source