Results 191 to 200 of about 20,657 (229)

Bromodomain and Extraterminal Protein Inhibition: A Novel Therapeutic Strategy in Arthritis. [PDF]

J Inflamm Res
Sheng W, Zhao J, Yu F, Wang D, Zeng H, Liu P.   +5 more
europepmc   +1 more source

HIV proviral transcription and infectivity are enhanced by neddylation. [PDF]

J Virol
Vaca CC, Hudson H, Clerc I, Song C, D'Aquila RT.   +4 more
europepmc   +1 more source

Controlling Intramolecular Rotation with Five-Membered Heterocycles Facilitates the Design of Highly Cell-Permeable Xanthene-Based Fluorogenic Probes. [PDF]

J Am Chem Soc
Reja SI, Hori Y, Takeda Y, Nishiura M, Minoshima M, Kikuchi K.   +5 more
europepmc   +1 more source

Exploring the Impact of miR-34b-5p on BRD4 Gene Expression in Triple-Negative Breast Cancer Cells. [PDF]

Biomed Res Int
Ibrahim MA, Jalali H, Azarnia M.
europepmc   +1 more source

Fluorinated prodrug-engineered nano-remodeler relieves tumor hypoxia for dual-enhanced ferroptosis-immunotherapy. [PDF]

Cell Rep Med
Lei J, Sun X, Shi J, Wang P, Guan Q, Zhang Z, He Z, Sun J, Huang P, Lin J, Luo C, Zhang S.   +11 more
europepmc   +1 more source

The BRD4-nucleosome interaction is enhanced modestly and non-selectively by histone acetylation. [PDF]

Nucleic Acids Res
Lambrechts LS, Reid XJ, Kambanis L, Luong C, Kobakhidze E, Daners A, Zhong Y, Patel K, Franck CK, Sani HM, Taylor C, Low JKK, Payne RJ, Mackay JP.   +13 more
europepmc   +1 more source

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Synthesis, SAR, and application of JQ1 analogs as PROTACs for cancer therapy.

Bioorganic & Medicinal Chemistry
JQ1 is a wonder therapeutic molecule that selectively inhibits the BRD4 signaling pathway and is thus widely used in the anticancer drug discovery program.
Soumik De, Raghaba Sahu, Shubhendu Palei, Laxmi Narayan Nanda   +3 more
semanticscholar   +3 more sources

Charge Reversal Yolk-Shell Liposome Co-loaded JQ1 and Doxorubicin with High Drug Loading and Optimal Ratio for Synergistically Enhanced Tumor Chemo-immunotherapy via Blockade PD-L1 Pathway.

International journal of pharmaceutics, 2023
Antitumor immunotherapy has become a powerful therapeutic modality to identify and kill various malignant tumors by harnessing the immune system. However, it is hampered by the immunosuppressive microenvironment and poor immunogenicity in malignant ...
Dechun Liu, Kunwei Li, Linlin Gong, Luyao Fu, Dan Yang   +4 more
semanticscholar   +1 more source

JQ1 attenuates psychostimulant- but not opioid-induced conditioned place preference

Behavioural Brain Research, 2022
Epigenetic mechanisms play important roles in the neurobiology of substance use disorder. In particular, bromodomain and extra-terminal domain (BET) proteins, a class of histone acetylation readers, have been found to regulate cocaine conditioned behaviors, but their role in the behavioral response to other drugs of abuse remains unclear.
C J, Babigian, H J, Wiedner, C, Wahlestedt, G C, Sartor   +3 more
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JQ1: a novel potential therapeutic target.

Die Pharmazie, 2018
The bromo- and extra-terminal domain (BET) signaling pathway plays an important role in cell proliferation, immune responses, and pro-inflammatory events. JQ1 as a first-in-class potent and selective inhibitor of the BRD4 signaling pathway is widely used for tumor biology studies.
Xiaoyu Shi, Xiaoyu Shi, Chen Liu, Chen Liu, Baoqing Liu, Baoqing Liu, Juntao Chen, Juntao Chen, Xiaoying Wu, Xiaoying Wu, jWeihua Gong, Weihua Gong   +5 more
openaire   +2 more sources