Results 221 to 229 of about 20,657 (229)

Abstract LB-2: Open innovation drug discovery: A study in JQ1.

Cancer Research, 2013
Abstract Collaborative research from our laboratory, in 2010, produced a first-in-class inhibitor of BET bromodomain proteins (JQ1). As an effort to promote a more open-innovation model of drug discovery, we endeavored to provide JQ1 without restriction of cost or delay to the scientific community.
Daniel L. Shaw, Charles Y. Lin, Richard P. Oakley, Nicholas P. Semenkovich, Jun Qi, James E. Bradner   +5 more
openaire   +1 more source

Abstract 1293: JQ1 sensitivity of patient-derived xenograft models of cholangiocarcinoma

Cancer Research, 2016
Abstract Cholangiocarcinoma (CCA) is a lethal malignancy arising from cholangiocytes in any part of the biliary tree. The incidence of CCA has been on the rise worldwide, and the prognosis and clinical outcome have remained essentially unchanged for 30 years.
Aubrey L. Miller, Patrick L. Garcia, Tracy L. Gamblin, Leona N. Council, Xiangqin Cui, James E. Bradner, Eddy S. Yang, Karina J. Yoon   +7 more
openaire   +1 more source

JQ1, a Potential Therapeutic Molecule for Myeloid Leukemia with PTEN Deficiency

Blood, 2016
Abstract Acute myeloid leukemia (AML) is a hematologic malignancy that continues to have high relapse and treatment-related mortality rates, despite recent advances in clinical management and therapy. Janus kinase (JAK) inhibitors inhibit the activity of the JAK/STAT pathway and have demonstrated some clinical responses in AML patients ...
Nicholas J Baltz, Natalia C Colorado, Yan Yan, Shelly Lensing, Delli Robinson, Michele H. Cottler-Fox, Jason E Farrar, Peter Dean Emanuel, Y. Lucy Liu   +8 more
openaire   +1 more source

A folic acid-decorated nanoparticles loaded JQ1 for oral squamous cell carcinoma therapy

Chinese Chemical Letters, 2023
De-ling Zeng, Zhongkai Ma, Xin Zan, Ting Luo, Xiang Wang, Xiang Gao, Xianghui Fu   +6 more
semanticscholar   +1 more source

Effects of bromodomain and extra-terminal inhibitor JQ1 and interleukin-6 on breast cancer cells

Molecular Biology Reports, 2023
Atefeh Sharifhoseini, Masoud Heshmati, A. Soltani, Mahshad Entezam, H. Shirzad, M. Sedehi, Babri A Judd, M. Jami, Mahdi Ghatrehsamani   +8 more
semanticscholar   +1 more source

T020 Targeting SALL4 by JQ1 in serous epithelial ovarian cancer

Clinica Chimica Acta, 2022
Y. Wu, Y. Pei, K. Li, X. Lou, W. Cui
openaire   +1 more source

BRD4 inhibition by JQ1 protects against LPS-induced cardiac dysfunction by inhibiting activation of NLRP3 inflammasomes

Molecular Biology Reports, 2022
Wenjun Li, Xiufeng Shen, Shenglan Feng, Yue Liu, Huiying Zhao, Guohao Zhou, Ming Sang, Xiaodong Sun, Rong Jiao, Fuyuan Liu   +9 more
semanticscholar   +1 more source

The epigenetic modifying compound, JQ1+, increases apoptosis in pituitary tumours

Endocrine Abstracts, 2016
Kate E. Lines, Mark Stevenson, Panagis Filippakopoulos, Susanne Muller, Stefan Knapp, Chas Bountra, Rajesh V Thakker   +6 more
openaire   +1 more source

Letter to the Editor, “BET Inhibitor JQ1 Blocks Inflammation and Bone Destruction”

Journal of Dental Research, 2014
S J, Hogg, R W, Johnstone, J, Shortt
openaire   +2 more sources