Results 61 to 70 of about 20,657 (229)

Small Molecule BRD4 Inhibitors Apabetalone and JQ1 Rescues Endothelial Cells Dysfunction, Protects Monolayer Integrity and Reduces Midkine Expression

Molecules, 2022
NF-κB signaling is a key regulator of inflammation and atherosclerosis. NF-κB cooperates with bromodomain-containing protein 4 (BRD4), a transcriptional and epigenetic regulator, in endothelial inflammation.
S. Shahid, Marlena Pantakani, L. Binder, Andreas Fischer, Krishna Pantakani, A. R. Asif   +5 more
semanticscholar   +1 more source

Energy transmutation in nonequilibrium quantum systems [PDF]

, 2014
We investigate the particle and heat transport in quantum junctions with the geometry of star graphs. The system is in a nonequilibrium steady state, characterized by the different temperatures and chemical potentials of the heat reservoirs connected to ...
Mintchev, Mihail, Santoni, Luca, Sorba, Paul   +2 more
core   +3 more sources

Chromatin remodeling induced by ARID1A loss in lung cancer promotes glycolysis and confers JQ1 vulnerability.

Cancer Research, 2022
ARID1A is a key mammalian SWI/SNF complex subunit that is mutated in 5%-11% of lung cancers. Although recent studies have elucidated the mechanism underlying dysregulation of SWI/SNF complexes in cancers, the significance of ARID1A loss and its ...
Xiaoyu Liu, Zhi Li, Zhongmin Wang, Fei Liu, Linling Zhang, Ji-Hong Ke, Xu Xu, Yue-fang Zhang, Yiting Yuan, T. Wei, Qungang Shan, Yingjie Chen, Wei Huang, Jie Gao, N. Wu, Fuliang Chen, Lunquan Sun, Z. Qiu, Yuezhen Deng, Wang Xiaojing   +19 more
semanticscholar   +1 more source

Evaluation of JQ1 Combined With Docetaxel for the Treatment of Prostate Cancer Cells in 2D- and 3D-Culture Systems

Frontiers in Pharmacology, 2022
Introduction: Prostate cancer (PCa) is dependent on coupled androgen-androgen receptor (AR) signaling for growth and progression. Significant efforts have been made in this research field, as hormonal therapies have greatly improved the survival of ...
Yipeng Xu, Gabriela Páchniková, Dorothea Przybilla, R. Schäfer, Yingying Cui, Dan Zhou, Zihao Chen, Anthony Zhao, U. Keilholz   +8 more
semanticscholar   +1 more source

Targeting Hippo coactivator YAP1 through BET bromodomain inhibition in esophageal adenocarcinoma

Molecular Oncology, 2020
Hippo/YAP1 signaling is a major regulator of organ size, cancer stemness, and aggressive phenotype. Thus, targeting YAP1 may provide a novel therapeutic strategy for tumors with high YAP1 expression in esophageal cancer (EC).
Shumei Song, Yuan Li, Yan Xu, Lang Ma, Melissa Pool Pizzi, Jiankang Jin, Ailing W Scott, Longfei Huo, Ying Wang, Jeffrey H. Lee, Manoop S. Bhutani, Brian Weston, Namita D Shanbhag, Randy L. Johnson, Jaffer A. Ajani   +14 more
doaj   +1 more source

BET Protein Inhibition Regulates Macrophage Chromatin Accessibility and Microbiota-Dependent Colitis

Frontiers in Immunology, 2022
IntroductionIn colitis, macrophage functionality is altered compared to normal homeostatic conditions. Loss of IL-10 signaling results in an inappropriate chronic inflammatory response to bacterial stimulation.
Michelle Hoffner O’Connor, Michelle Hoffner O’Connor, Ana Berglind, Ana Berglind, Meaghan M. Kennedy Ng, Meaghan M. Kennedy Ng, Benjamin P. Keith, Benjamin P. Keith, Zachary J. Lynch, Matthew R. Schaner, Erin C. Steinbach, Erin C. Steinbach, Jeremy Herzog, Omar K. Trad, William R. Jeck, Janelle C. Arthur, Janelle C. Arthur, Janelle C. Arthur, Jeremy M. Simon, Jeremy M. Simon, Jeremy M. Simon, Jeremy M. Simon, R. Balfour Sartor, Terrence S. Furey, Terrence S. Furey, Terrence S. Furey, Shehzad Z. Sheikh, Shehzad Z. Sheikh   +27 more
doaj   +1 more source

Human Galectin-9 Is a Potent Mediator of HIV Transcription and Reactivation. [PDF]

, 2016
Identifying host immune determinants governing HIV transcription, latency and infectivity in vivo is critical to developing an HIV cure. Based on our recent finding that the host factor p21 regulates HIV transcription during antiretroviral therapy (ART),
Abdel-Mohsen, Mohamed, Chavez, Leonard, Chew, Glen M, Danesh, Ali, Deeks, Steven G, Deng, Xutao, Hirashima, Mitsuomi, Hoh, Rebecca, Keating, Sheila, Lanteri, Marion, Ndhlovu, Lishomwa C, Niki, Toshiro, Norris, Philip J, Pillai, Satish K, Sacha, Jonah B, Samuels, Michael L, Shikuma, Cecilia M, Tandon, Ravi   +17 more
core   +4 more sources

An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4.

PLoS Pathogens, 2016
The human HSV-1 and -2 are common pathogens of human diseases. Both host and viral factors are involved in HSV lytic infection, although detailed mechanisms remain elusive.
Ke Ren, Wei Zhang, Xiaoqing Chen, Yingyu Ma, Yue Dai, Yimei Fan, Yayi Hou, Ren Xiang Tan, Erguang Li   +8 more
doaj   +1 more source

Single-cell trajectory analysis reveals a CD9 positive state to contribute to exit from stem cell-like and embryonic diapause states and transit to drug-resistant states

Cell Death Discovery, 2023
Bromo- and extra-terminal domain (BET) inhibitors (BETi) have been shown to decrease tumor growth in preclinical models and clinical trials. However, toxicity and rapid emergence of resistance have limited their clinical implementation. To identify state
Xi Li, Alfonso Poire, Kang Jin Jeong, Dong Zhang, Gang Chen, Chaoyang Sun, Gordon B. Mills   +6 more
doaj   +1 more source

Verlinde's emergent gravity in an $\boldsymbol{n-}$dimensional, non-additive Tsallis' scenario

, 2018
This paper brings together four distinct but very important physical notions: 1) Entropic force, 2) Entropy-along-a-curve, 3) Tsallis' q-statistics, and 4) Emergent gravitation.
Ferri, G. L., Plastino, A., Rocca, M. C., Zamora, D. J.   +3 more
core   +1 more source