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Background Lupus nephritis (LN) affects up to 80% of juvenile-onset systemic lupus erythematosus (JSLE) patients. The value of commonly available biomarkers, such as anti-dsDNA antibodies, complement (C3/C4), ESR and full blood count parameters in the identification of active LN remains uncertain.
Michael W Beresford +2 more
exaly +3 more sources
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Study of NLRP3 Single Nucleotide Polymorphisms in Juvenile Systemic Lupus Erythematosus (JSLE)
Immunological Investigations, 2023Juvenile systemic lupus erythematosus (JSLE) is a multifaceted multifactorial disorder with an unclear etiopathogenesis. Environmental factors, genetic factors, and dysregulated and defective immune system responses are known to have a role in JSLE etiopathogenesis.
Nima Rezaei +2 more
exaly +3 more sources
AB0658 Predictors of access to care in JSLE - evidence from the UK JSLE cohort study
Annals of the Rheumatic Diseases, 2012Background Delays in access to specialist care for children with paediatric rheumatic disease are likely to be associated with adverse outcomes 1,2 . Factors influencing access to care for Juvenile-onset Systemic Lupus Erythematosus (JSLE) remain mainly unknown.
E. Smith +4 more
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Up to 80% of juvenile-onset systemic lupus erythematosus (jSLE) patients develop lupus nephritis (LN) that affects treatment and prognosis. Easily accessible biomarkers do not exist to reliably diagnose LN, leaving kidney biopsies as the gold-standard.
Christian M Hedrich +2 more
exaly +3 more sources
Clinical Predictors of Active LN Development in Children – Evidence From the UK JSLE Cohort Study
Background Juvenile-onset systemic lupus erythematosus (JSLE) patients may develop lupus nephritis (LN) during their initial presentation, or later in their disease. This study aimed to assess whether clinical/demographic factors characterize patients with LN within the United Kingdom JSLE Cohort Study, and ...
Michael W Beresford +2 more
exaly +3 more sources
International Journal of Pediatric Otorhinolaryngology, 2017
Juvenile Systemic lupus erythematosus (jSLE) is an autoimmune disease with the potential to affect a variety of organs in children or adolescents. jSLE is characterized by its severity and more widespread organ involvement specially central nervous system.To evaluate auditory processing and cognitive functions in children and adolescents with SLE ...
Takwa Gabr
exaly +3 more sources
Juvenile Systemic lupus erythematosus (jSLE) is an autoimmune disease with the potential to affect a variety of organs in children or adolescents. jSLE is characterized by its severity and more widespread organ involvement specially central nervous system.To evaluate auditory processing and cognitive functions in children and adolescents with SLE ...
Takwa Gabr
exaly +3 more sources
Objective To systematically review and summarize the available literature regarding the effectiveness and safety of biologics in the treatment of juvenile-onset systemic lupus erythematosus. Methods PubMed was systematically searched ...
Matthew P Keasey, Michael W Beresford
exaly +4 more sources
FRI0364 Neuropsychiatric manifestations in juvenile systemic lupus erythematosus (JSLE)
Annals of the Rheumatic Diseases, 2012Background The nervous system affects children and adults with systemic lupus erythematosus (SLE) and is associated with a worse prognosis and elevated mortality. In juvenil onset SLE (jSLE) the prevalence of neuropsychiatric manifestations is even more frequently observed when compared to adult onset SLE.
A.T. Lapa +6 more
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FRI0334 Juvenile systemic lupus erythematosus (JSLE) debut and clinical course
Annals of the Rheumatic Diseases, 2012Background JSLE is a multisystemic auto immune disease but its onset not always is multiorganic. Different types of onset have been recognized. Multysistemic onset is the typical type, an oligosystemic (less than 4 target organs involved) is also observed, other patients have an atypical onset of SLE and others had an anti-phospholipid syndrome as a ...
A. Mosquera, C. Malagon
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