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Unmasking Juvenile Systemic Lupus Erythematosus (JSLE): Multisystemic Manifestations in an Adolescent Male, A Rare Case Report [PDF]

Clinical Case Reports
Juvenile Systemic Lupus Erythematosus (JSLE) is a rare and chronic multisystem autoimmune condition with an accelerated course compared with adult‐onset SLE.
Shafaq Nazia, Aliza Andaleeb, Abdul Moiz, Hareem Ahmed, Muhammad Hassaan Javaid, Abubakr Mahmoud   +5 more
doaj   +2 more sources

An Unprecedented Triad: Simultaneous Acute Pancreatitis, Axonal Polyneuropathy, and Type 1 Diabetes Mellitus in a Catastrophic Juvenile Lupus Flare [PDF]

Clinical Case Reports
A 14‐year‐old female with juvenile systemic lupus erythematosus (jSLE) presented with a life‐threatening and previously unreported triad: the simultaneous onset of acute pancreatitis, severe axonal polyneuropathy, and autoimmune Type 1 Diabetes (T1D ...
Laiba Hashmi, Fazeela Bibi, Kishan Chand Lohana, Khalil El Abdi, Zonaira Mushahid, Muhammad Asad Asif, Mahnoor Ilyas, Osvani Leyva Matos, Ariba Munam, Muhammad Saad Sammi, Samaha Kanden Mohammed Shafi, Said Hamid Sadat   +11 more
doaj   +2 more sources

Case Report: Novel UNC93B1 variant causes rheumatoid arthritis and interstitial pneumonia [PDF]

Frontiers in Immunology
BackgroundUNC93B1 is a transmembrane protein essential for regulating toll-like receptors (TLRs). Pathogenic variants in human UNC93B1 have recently been described in a limited number of patients with childhood systemic lupus erythematosus and chilblain ...
Tingyan He, Junbin Ou, Lijuan Huang, Xinyi Zhou, Linlin Wang, Xiaolin Li, Jun Yang   +6 more
doaj   +2 more sources

The role of assessment of renal biopsy in electron microscopy in making a diagnosis of juvenile-onset systemic lupus erythematosus in a 16-year-old female patient with depression and proteinuria – case report

Central European Journal of Immunology, 2022
The course of juvenile-onset systemic lupus erythematosus may vary, from rapid multiorgan involvement to insidious development mimicking different medical conditions.
Tomasz Koszutski, Agnieszka Wiernik, Lidia Hyla-Klekot, Natalia Matysiak, Grażyna Kucharska   +4 more
doaj   +1 more source

Abstract 13 — Comparison of Clinical and Serological Features in Juvenile and Adult-Onset Systemic Lupus Erythematosus

Journal of Clinical Rheumatology and Immunology, 2023
Background Systemic lupus erythematosus (SLE) has varying clinical and serological features in juvenile and adult-onset disease groups, depending on the ethnicity. Objectives: To compare the disease characteristics of patients with adult-onset (ASLE) and
Babur Salim, Anum Khan, Haris Gul, Saba Samreen, Shahida Perveen   +4 more
doaj   +1 more source

Juvenile systemic lupus erythematosus presenting only as nonscarring alopecia

Indian Journal of Paediatric Dermatology, 2022
Juvenile onset systemic lupus erythematosus (JSLE) is a rare multisystem, autoimmune disorder. Alopecia in SLE generally follows a pre-established disease with systemic symptoms. A 13-year-old girl presented with sudden hair loss over the vertex of scalp
N M Vinitha, Reena Rai, G Uma Maheswari
doaj   +1 more source

Association of rs7574865 G/T polymorphism of STAT4 gene with juvenile onset of systemic lupus erythematosus

Современная ревматология, 2022
Systemic lupus erythematosus (SLE) with juvenile onset (jSLE) is a complex autoimmune disease involving many organs and systems. The single nucleotide polymorphism rs7574865 of the STAT4 (signal switch and transcription activator 4) gene is associated ...
M. Yu. Krylov, M. I. Kaleda, I. A. Guseva, N. V. Konovalova, D. A. Varlamov   +4 more
doaj   +1 more source

Macrophage activation syndrome triggered by systemic lupus erythematosus flare: successful treatment with a combination of dexamethasone sodium phosphate, intravenous immunoglobulin, and cyclosporine: a case report

Journal of Medical Case Reports, 2021
Background Macrophage activation syndrome is classified as a secondary form of hemophagocytic lymphohistiocytosis. It is a hyperinflammatory complication observed to be comorbid with a variety of autoimmune diseases, including adult-onset Still’s disease
Wesam Gouda, Faisal Alsaqabi, Abdelhfeez Moshrif, Awad S. Abbas, Tarek M. Abdel-Aziz, Md Asiful Islam   +5 more
doaj   +1 more source

Clinical variants of skin and mucous membrane lesions in systemic lupus erythematosus with juvenile onset

Современная ревматология, 2023
Skin and mucous membrane lesions are frequently seen in systemic lupus erythematosus (SLE) with the juvenile onset (juSLE), and they are extremely diverse.
M. I. Kaleda, S. O. Salugina, I. P. Nikishina, A. N. Arefieva   +3 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source