Results 21 to 30 of about 53,292,385 (218)

Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus (jSLE)

open access: yesMolecular and Cellular Pediatrics, 2023
AbstractSystemic lupus erythematosus (SLE) is a rare autoimmune/inflammatory disease with significant morbidity and mortality. Approximately 15–20% of SLE patients develop the disease during childhood or adolescence (juvenile-onset SLE/jSLE). Patients with jSLE exhibit more variable and severe disease when compared to patients with disease-onset during
Valentina Natoli   +3 more
openaire   +3 more sources

The role of neutrophil apoptosis in juvenile‐onset systemic lupus erythematosus [PDF]

open access: yesArthritis & Rheumatism, 2009
AbstractObjectiveAccumulation of apoptotic cells may lead to the development of systemic lupus erythematosus (SLE) through a breakdown in immune tolerance. Altered neutrophil apoptosis may contribute to nuclear autoantigen exposure, ultimately leading to autoantibody generation.
Angela, Midgley   +4 more
openaire   +2 more sources

IgG anti-apolipoprotein A-1 antibodies in patients with systemic lupus erythematosus are associated with disease activity and corticosteroid therapy: an observational study. [PDF]

open access: yes, 2015
IgG anti-apolipoprotein A-1 (IgG anti-apoA-1) antibodies are present in patients with systemic lupus erythematosus (SLE) and may link inflammatory disease activity and the increased risk of developing atherosclerosis and cardiovascular disease (CVD) in ...
Davari, M   +19 more
core   +1 more source

Lack of the long pentraxin PTX3 promotes autoimmune lung disease but not glomerulonephritis in murine systemic lupus erythematosus. [PDF]

open access: yes, 2011
The long pentraxin PTX3 has multiple roles in innate immunity. For example, PTX3 regulates C1q binding to pathogens and dead cells and regulates their uptake by phagocytes. It also inhibits P-selectin-mediated recruitment of leukocytes.
Mantovani Alberto   +32 more
core   +1 more source

Severe Juvenile-Onset Systemic Lupus Erythematosus: A Case Series-Based Review and Update

open access: yesChildren, 2023
Juvenile-onset systemic lupus erythematosus (jSLE) is a multisystemic disease diagnosed in young patients based on the clinical criteria of the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR).
Sergi Huerta-Calpe   +4 more
doaj   +1 more source

Disease characteristics in patients with juvenile- and adult-onset systemic lupus erythematosus: A multi-center comparative study

open access: yesThe Turkish Journal of Gastroenterology, 2022
Objectives: This study aims to compare disease characteristics in patients with juvenile-onset systemic lupus erythematosus (JSLE) and adult-onset systemic lupus erythematosus (ASLE). Patients and methods: Between June 2010 and March 2020, a total of
Sherif M Gamal   +4 more
doaj  

The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis [PDF]

open access: yes, 2013
Systemic sclerosis (SSc) is a fibrotic autoimmune disease in which the genetic component plays an important role. One of the strongest SSc association signals outside the human leukocyte antigen (HLA) region corresponds to interferon (IFN) regulatory ...
Schuerwegh, A. J.   +219 more
core   +2 more sources

Juvenile-onset systemic lupus erythematosus in Malay children

open access: yesSaudi Medical Journal, 2018
[No abstract available].
Ali S, Jawad, Wan Zuraida W A, Hamid
openaire   +2 more sources

Autoantibodies against complement C1q in systemic lupus erythemathosus [PDF]

open access: yes, 2008
Complement and C1q, the first component of the classical pathway of activation of the complement system, are considered to be involved in the pathogenesis of systemic lupus erythematosus (SLE), a systemic autoimmune disease.
Bigler, Cornelia
core   +1 more source

Phototesting and photoprotection in LE [PDF]

open access: yes, 1997
Photosensitivity and induction of skin lesions following UV radiation is a common problem of patients with cutaneous and systemic forms of lupus erythematosus.
Kind, P., Walchner, M., Messer, G.
core   +1 more source

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