Results 161 to 170 of about 630,673 (354)

Revisiting intraperitoneal chemotherapy for advanced high‐grade serous ovarian cancer

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To compare overall survival (OS) in patients with high‐grade serous ovarian cancer (HGSOC) treated with intraperitoneal (IP) chemotherapy versus intravenous (IV) chemotherapy. Methods A retrospective study of Stage III HGSOC with optimal primary cytoreduction during 2007–2019, followed by adjuvant IP or IV chemotherapy.
Joshua S Cheruvathur   +7 more
wiley   +1 more source

Loving in Secret, Grieving in Silence: Emotion‐Focused Therapy With the Other Woman After an Affair in a Japanese Cultural Context

open access: yesJournal of Clinical Psychology, EarlyView.
ABSTRACT Although extensive literature exists on supporting couples after an affair, there is a notable lack of clinical focus on working with the other woman—a figure often viewed as a moral transgressor and subjected to social stigma. Despite this marginalization, her experience is frequently marked by secrecy, emotional ambivalence, and a mix of ...
Shigeru Iwakabe
wiley   +1 more source

In the Furtherance of Justice, Injustice, or Both? A Multilevel Analysis of Courtroom Context and the Implementation of Three Strikes [PDF]

open access: yes, 2014
A hierarchical logistic model is used to analyze data on Three Strikes-eligible offenders in California and the counties in which they are sentenced.
Chen, Elsa Y.
core   +1 more source

Clinical Evaluation of Drug–Drug Interactions Between Bictegravir and Strong Inhibitors/Inducers of the CYP3A4, UGT1A1, or P‐gp Pathways

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract In addition to antiretroviral therapy (ART), people with HIV often take medications to treat comorbidities. It is therefore important to assess these medications for potential drug‐drug interactions, which may affect the safety and efficacy of ART. Three phase I studies were conducted in adult participants without HIV. The pharmacokinetics (PK)
Priyanka Arora   +4 more
wiley   +1 more source

¿Pueden los juzgadores penales inaplicar el Código Penal?

open access: yesForo, Revista de Derecho, 2017
¿Un juez penal puede inaplicar una disposición del código penal o del procedimiento penal? En general, por el principio de legalidad, no. Sin embargo, la jurisprudencia y la doctrina han demostrado que sí se puede inaplicar normas penales, cuando éstas ...
Ramiro Fernando Ávila Santamaría
doaj  

Pharmacokinetics and Safety of Fezolinetant in Women with Hepatic or Renal Impairment

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract The neurokinin 3 receptor antagonist fezolinetant is an approved treatment for vasomotor symptoms due to menopause. The impacts of hepatic and renal impairment on the pharmacokinetics and safety of a single oral dose of fezolinetant 30 mg were investigated in two independent studies.
Megumi Iwai   +8 more
wiley   +1 more source

A Phase 1 Randomized Study: Garadacimab Pharmacokinetics, Safety, and Tolerability After Administration via Autoinjector/Pre‐Filled Pen Versus Pre‐Filled Syringe in Healthy Participants

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract Garadacimab is a novel, fully human, anti‐activated factor XII monoclonal antibody approved for long‐term prophylaxis of patients with hereditary angioedema. This open‐label, parallel‐group, Phase 1, single‐center, bridging study in healthy adults (18–55 years of age) characterized the pharmacokinetics and safety of a single 200 mg ...
Fiona Glassman   +9 more
wiley   +1 more source

INTER-REGIONAL SCIENCE & PRACTICE CONFERENCE «JUDICIAL DISCRETION: ITS CONCEPT, GROUNDS, AND CONSTRAINTS»

open access: yesТеория и практика судебной экспертизы, 2015
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O. Miklyaeva
doaj  

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