Results 101 to 110 of about 585 (130)
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Type III CRISPR-Cas provides resistance against nucleus-forming jumbo phages via abortive infection
Molecular Cell, 2022SUMMARYBacteria have diverse defences against phages. In response, jumbo phages evade multiple DNA-targeting defences by protecting their DNA inside a nucleus-like structure. We previously demonstrated that RNA-targeting type III CRISPR–Cas systems provide jumbo phage immunity by recognising viral mRNA exported from the nucleus for translation.
Peter C Fineran
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Characterization of a lipid-based jumbo phage compartment as a hub for early phage infection
Cell Host and MicrobeViral genomes are most vulnerable to cellular defenses at the start of the infection. A family of jumbo phages related to phage ΦKZ, which infects Pseudomonas aeruginosa, assembles a protein-based phage nucleus to protect replicating phage DNA, but how it is protected prior to phage nucleus assembly is unclear.
Deepto Mozumdar, Joseph Bondy-Denomy
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Current Biology, 2023
In this Quick guide, Harding et al. introduce jumbo phages - the overlooked giants of the phage universe.
Kate R, Harding +2 more
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In this Quick guide, Harding et al. introduce jumbo phages - the overlooked giants of the phage universe.
Kate R, Harding +2 more
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Immediate targeting of host ribosomes by jumbo phage encoded proteins
2023AbstractBacteriophages must seize control of the host gene expression machinery to promote their own protein synthesis. Since the bacterial hosts are armed with numerous anti-phage defence systems, it is essential that mechanisms of host take-over act immediately upon infection.
Milan Gerovac +5 more
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Here we collected 59,652,008 putative viral genomes spanning seven different habitats by using 38 public metagenome datasets, an integrated public viral genome database (IGNR), and a pig gut viral genome database (PGV). A total of 10,754 megaphage genomes were obtained with genome sizes from 200 to 831 kb.
Wei, Chao, Huang, Lusheng
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Wei, Chao, Huang, Lusheng
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A novel jumbo Tenacibaculum maritimum lytic phage with head-fiber-like appendages
Archives of Virology, 2019A novel jumbo bacteriophage (myovirus) is described. The lytic phage of Tenacibaculum maritimum, which is the etiological agent of tenacibaculosis in a variety of farmed marine fish worldwide, was plaque-isolated from seawater around a fish aquaculture field in Japan. The phage had an isometric head 110-120 nm in diameter, from which several 50- to 100-
Yasuhiko Kawato +9 more
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A cytoskeletal vortex drives phage nucleus rotation during jumbo phage replication in E. coli.
2022Nucleus-forming jumbo phages establish an intricate subcellular organization, enclosing phage genomes within a proteinaceous shell called the phage nucleus. During infection in Pseudomonas, some jumbo phages assemble a bipolar spindle of tubulin-like PhuZ filaments that positions the phage nucleus at midcell and drives its intracellular rotation.
Birkholz, Erica A +8 more
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Conserved jumbo phage factors required for protein import into a phage nucleus
AbstractBacteriophages use diverse mechanisms to evade anti-phage defenses systems. ΦKZ-like jumbo phages assemble a proteinaceous nucleus-like compartment that excludes antagonistic host nucleases, while internalizing DNA replication and transcription machinery1,2,3,4.Claire Kokontis +3 more
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Investigating the early stages of infection of nucleus-forming jumbo phage
Biophysical Journal, 2023Zaida K. Rodriguez +9 more
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