Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway. [PDF]
, 2010 BACKGROUND: Although an increasing number of histone demethylases have been identified and biochemically characterized, their biological functions largely remain uncharacterized, particularly in the context of human diseases such as cancer.
Field, Helen I +12 more
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The Functions and Mechanisms of Histone Demethylase JMJD1A in Urinary Bladder Cancer Development [PDF]
, 2015 JMJD1A（JumonjiCdomain-containing1A），又名JHDM2A，KDM3A，是一种组蛋白去甲基化酶，可以特异性去除H3K9位点的一甲基化和二甲基化，在组蛋白甲基化修饰中起到重要作用。JMJD1A表达受到低氧诱导因子HIF-1α（hypoxia-induciblefactor1α）的调节，并且参与到肿瘤细胞对低氧环境的适应性调节过程中。 膀胱癌是世界范围内高发和高致死率的恶性肿瘤之一。已有报道JMJD1A在膀胱癌肿瘤组织中高表达，但是JMJD1A在膀胱癌的发生发展机制尚不清楚 ...
秦丽萍
core
Role of histone methyltransferase “EZH2” in human cancer [PDF]
, 2011 Epigenetic alternations significantly contribute many disease progressions as the genetic changes do. However, there is a crucial difference between genetic and epigenetic alterations, which has important implications for development of cancer treatments.
Sahu, Rashmi Ranjan
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Small molecule inhibitor of jumonji C domain–containing histone demethylases (JHDMs) [PDF]
Science-Business eXchange, 2011 openaire +1 more source
Characterization of Arabidopsis thaliana mutants lacking a jumonji domain containing histone demethylase and a set domain containing histone methyl transferase [PDF]
, 2010 Condensation of chromatin and alteration of chemical groups in the proteins around which the DNA is wrapped play major role in regulation of transcription.
Reddy, Swetha Mamidi
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Quantitative analysis of jumonji C domain–containing histone demethylase (JHDM)-targeting compounds [PDF]
Science-Business eXchange, 2013 openaire +1 more source
Epigenome Modifying Tools In Asthma [PDF]
, 2015 Adcock,, Brook, PO, Durham, AL, Perry, M
core +1 more source
The effects of 2-hydroxyglutarate on the tumorigenesis of gliomas [PDF]
, 2018 Klein, Andreas +2 more
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Inhibition of H3K27me3 Histone Demethylase Activity Prevents the Proliferative Regeneration of Zebrafish Lateral Line Neuromasts [PDF]
, 2017 Beier Bao +4 more
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SUN-210 THE HISTONE DEMETHYLASE JUMONJI DOMAIN-CONTAINING PROTEIN 3 ACTS AS AN EPIGENETIC SUPPRESSOR OF RENAL FIBROSIS [PDF]
Kidney International Reports, 2019 openaire +1 more source