The roles of XJ13 and XJ44-specific mutations within the Candid #1 GPC in Junin virus attenuation [PDF]
Frontiers in Immunology, 2023 Junin virus (JUNV) is a member of the Arenaviridae family of viruses and is the pathogen responsible for causing Argentine hemorrhagic fever, a potentially lethal disease endemic to Argentina.
John Tyler Manning +8 more
doaj +2 more sources
Nuclease Activity of the Junín Virus Nucleoprotein C-Terminal Domain [PDF]
Viruses, 2023 The mammarenavirus Junín (JUNV) is the causative agent of Argentine hemorrhagic fever, a severe disease of public health concern. The most abundant viral protein is the nucleoprotein (NP), a multifunctional, two-domain protein with the primary role as ...
Alicia Armella Sierra +6 more
doaj +2 more sources
Junin Virus Activates p38 MAPK and HSP27 Upon Entry [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Junín virus (JUNV), a New World arenavirus, is a rodent-borne virus and the causative agent of Argentine hemorrhagic fever. Humans become infected through exposure to rodent host secreta and excreta and the resulting infection can lead to an acute ...
Collin J. Fitzpatrick +11 more
doaj +2 more sources
Junín Virus Pathogenesis and Virus Replication [PDF]
Viruses, 2012 Junín virus, the etiological agent of Argentine hemorrhagic fever, causes significant morbidity and mortality. The virus is spread through the aerosolization of host rodent excreta and endemic to the humid pampas of Argentina.
Olga Kolokoltsova +6 more
doaj +2 more sources
Immunization with GP1 but Not Core-like Particles Displaying Isolated Receptor-Binding Epitopes Elicits Virus-Neutralizing Antibodies against Junín Virus [PDF]
Vaccines, 2022 New World arenaviruses are rodent-transmitted viruses and include a number of pathogens that are responsible for causing severe human disease. This includes Junín virus (JUNV), which is the causative agent of Argentine hemorrhagic fever.
Gleyder Roman-Sosa +11 more
doaj +2 more sources
Junín virus induces autophagy in human A549 cells. [PDF]
PLoS ONE, 2019 Autophagy, a highly regulated degradative process that promotes cellular homeostasis, is increasingly recognised as a fundamental component of the cellular response against viral infection.
Maria Laura A Perez Vidakovics +4 more
doaj +2 more sources
Single dose rVSVΔG-JUNVGP vaccine protects guinea pigs against lethal Junin virus challenge [PDF]
npj Vaccines, 2021 Junin virus (JUNV) is a pathogen of biodefense importance due to its potential for aerosol transmission and mortality rates reaching 30%. Currently, there are no JUNV vaccines licensed by the United States Food and Drug Administration (FDA) for at-risk ...
Teresa E. Sorvillo +6 more
doaj +2 more sources
Development of a Reverse Genetic System to Generate Recombinant Chimeric Tacaribe Virus that Expresses Junín Virus Glycoproteins [PDF]
Pathogens, 2020 Mammarenaviruses are enveloped and segmented negative-stranded RNA viruses that comprise several pathogenic members associated with severe human hemorrhagic fevers. Tacaribe virus (TCRV) is the prototype for the New World group of mammarenaviruses and is
Sabrina Foscaldi +5 more
doaj +2 more sources
A single mutation (V64G) within the RING Domain of Z attenuates Junin virus. [PDF]
PLoS Neglected Tropical Diseases, 2020 Junin virus (JUNV) is a New World arenavirus that is the causative agent of Argentine hemorrhagic fever (AHF). Candid#1 (Can) is a live-attenuated vaccine strain of JUNV that since its introduction has resulted in a marked decrease in AHF incidence ...
Steven J Hallam +7 more
doaj +2 more sources
Antigen vehiculization particles based on the Z protein of Junin virus [PDF]
BMC Biotechnology, 2012 Background Arenavirus matrix protein Z plays an important role in virus budding and is able to generate enveloped virus-like-particles (VLPs) in absence of any other viral proteins.
Borio Cristina S +6 more
doaj +2 more sources