Results 11 to 20 of about 1,054,606 (156)

Lassa fever and Argentine hemorrhagic fever treatment in guinea pigs using broad-spectrum cap-dependent endonuclease inhibitors [PDF]

mBio
The class Bunyaviricetes encompasses several highly pathogenic viruses that cause lethal hemorrhagic fevers. Due to their limited prevention and treatment options and high pathogenicity, these viruses require handling in biosafety level-4 facilities ...
Junki Maruyama, Satoshi Taniguchi, Takeshi Saito, Shintaro Yamada, Rachel A. Reyna, Ruchi Paroha, Daiki Kobayashi, Gavriella Siman-Tov, Christine Click, Kirsten Littlefield, Shinsuke Toba, Yoshiyuki Taoda, Misato Shibazaki, Cheng Huang, Michihito Sasaki, Yasuko Orba, Hirofumi Sawa, Akihiko Sato, Slobodan Paessler   +18 more
doaj   +2 more sources

Potent inhibition of Junín virus infection by interferon in murine cells. [PDF]

PLoS Neglected Tropical Diseases, 2014
The new world arenavirus Junín virus (JUNV) is the causative agent of Argentine hemorrhagic fever, a lethal human infectious disease. Adult laboratory mice are generally resistant to peripheral infection by JUNV.
Cheng Huang, Aida G Walker, Ashley M Grant, Olga A Kolokoltsova, Nadezhda E Yun, Alexey V Seregin, Slobodan Paessler   +6 more
doaj   +2 more sources

RIG-I enhanced interferon independent apoptosis upon Junin virus infection. [PDF]

PLoS ONE, 2014
Junin virus (JUNV) is the etiological agent of Argentine hemorrhagic fever (AHF), a human disease with a high case-fatality rate. It is widely accepted that arenaviral infections, including JUNV infections, are generally non-cytopathic. In contrast, here
Olga A Kolokoltsova, Ashley M Grant, Cheng Huang, Jennifer K Smith, Allison L Poussard, Bing Tian, Allan R Brasier, Clarence J Peters, Chien-Te Kent Tseng, Juan C de la Torre, Slobodan Paessler   +10 more
doaj   +2 more sources

Immunogenicity of recombinant vesicular stomatitis virus-vectored vaccines expressing the Machupo virus glycoprotein in different genome positions [PDF]

Journal of Virology
Recombinant vesicular stomatitis virus (rVSV) is a powerful vaccine platform that elicits durable cellular and humoral immune responses. rVSV vaccines have successfully been used for various hemorrhagic fever-causing viruses. Here, we create and evaluate
Rachel Erickson, Paul Bates
doaj   +2 more sources

Márgenes brutos de las principales actividades agrícolas : en base a los cultivos de trigo/soja 2da, soja 1ra y maíz - Junín, General Arenales, Leandro N. Alem [PDF]

, 2022
El riesgo y la incertidumbre son importantes propiedades de la producción agrícola. El riesgo, a diferencia de la incertidumbre, es aquella situación en la cual tenemos información, no solo de eventos posibles, sino de sus probabilidades. En este reporte
Signorelli, Alejandro Gabriel, Telleria, María Guadalupe, Leavy, Sebastian, Melilli, Maria Paula   +3 more
core   +1 more source

Siglec-1 Expressed on Dendritic Cells is a New Receptor Implicated in Arenavirus Uptake

Proceedings, 2020
Arenaviruses are enveloped viruses that cause hemorrhagic fever outbreaks in humans and still lack an effective antiviral treatment. Upon early infection, these viruses target dendritic cells (DCs), which can promote systemic viral dissemination ...
Xabier Muniz-Trabudua, Cristina Borio, Marcos Bilen, Itziar Erkizia, Daniel Perez-Zsolt, Susana Benet, Javier Martinez-Picado, Nuria Izquierdo-Useros   +7 more
doaj   +1 more source

VelcroVax: a “Bolt-On” Vaccine Platform for Glycoprotein Display

mSphere, 2023
Having varied approaches to the design and manufacture of vaccines is critical in being able to respond to worldwide needs and newly emerging pathogens.
Natalie J. Kingston, Keith Grehan, Joseph S. Snowden, Mark Hassall, Jehad Alzahrani, Guido C. Paesen, Lee Sherry, Connor Hayward, Amy Roe, Sam Stephen, Darren Tomlinson, Antra Zeltina, Katie J. Doores, Neil A. Ranson, Martin Stacey, Mark Page, Nicola J. Rose, Thomas A. Bowden, David J. Rowlands, Nicola J. Stonehouse   +19 more
doaj   +1 more source

Estado de situación agropecuaria enero 2023 : cultivos, pasturas y plantaciones en el área de cobertura de INTA Junín [PDF]

, 2023
El presente trabajo analiza la situación de los principales cultivos, pasturas y plantaciones para los distritos de Junín, Leandro N. Alem, General Arenales y General Viamonte en el contexto climático actual al día 19 de enero de 2023, base de la ...
Signorelli, Alejandro Gabriel, Baldoni, Cesar, Telleria, María Guadalupe, Melilli, Maria Paula   +3 more
core   +1 more source

The Virus–Host Interplay in Junín Mammarenavirus Infection

Viruses, 2022
Junín virus (JUNV) belongs to the Arenaviridae family and is the causative agent of Argentine hemorrhagic fever (AHF), a severe human disease endemic to agricultural areas in Argentina.
Giovanna Lucrecia Gallo, Nora López, María Eugenia Loureiro   +2 more
doaj   +1 more source

Luminescent reporter cells enable the identification of broad‐spectrum antivirals against emerging viruses

Journal of Medical Virology, Volume 95, Issue 11, November 2023., 2023
Abstract The emerging viruses SARS‐CoV‐2 and arenaviruses cause severe respiratory and hemorrhagic diseases, respectively. The production of infectious particles of both viruses and virus spread in tissues requires cleavage of surface glycoproteins (GPs) by host proprotein convertases (PCs).
Karin Löw, Rebecca Möller, Cora Stegmann, Miriam Becker, Laura Rehburg, Helena Obernolte, Dirk Schaudien, Lisa Oestereich, Armin Braun, Stefan Kunz, Gisa Gerold   +10 more
wiley   +1 more source