Results 11 to 20 of about 2,613 (125)

Potent inhibition of Junín virus infection by interferon in murine cells. [PDF]

PLoS Neglected Tropical Diseases, 2014
The new world arenavirus Junín virus (JUNV) is the causative agent of Argentine hemorrhagic fever, a lethal human infectious disease. Adult laboratory mice are generally resistant to peripheral infection by JUNV.
Cheng Huang, Aida G Walker, Ashley M Grant, Olga A Kolokoltsova, Nadezhda E Yun, Alexey V Seregin, Slobodan Paessler   +6 more
doaj   +2 more sources

RIG-I enhanced interferon independent apoptosis upon Junin virus infection. [PDF]

PLoS ONE, 2014
Junin virus (JUNV) is the etiological agent of Argentine hemorrhagic fever (AHF), a human disease with a high case-fatality rate. It is widely accepted that arenaviral infections, including JUNV infections, are generally non-cytopathic. In contrast, here
Olga A Kolokoltsova, Ashley M Grant, Cheng Huang, Jennifer K Smith, Allison L Poussard, Bing Tian, Allan R Brasier, Clarence J Peters, Chien-Te Kent Tseng, Juan C de la Torre, Slobodan Paessler   +10 more
doaj   +2 more sources

Comparison of Vaccine Platforms for Machupo Virus [PDF]

Vaccines
Background/Objectives: Pathogenic mammarenaviruses cause severe hemorrhagic and neurologic disease in humans. Machupo virus (MACV), a New World (NW) mammarenavirus, causes Bolivian hemorrhagic fever in humans, and there are no approved vaccines. Methods:
Rachel Erickson, Hiromi Muramatsu, Sachchidanand Tiwari, Sowmya Sriram, Fernanda Caroline Coirada, Norbert Pardi, Paul Bates   +6 more
doaj   +2 more sources

Siglec-1 Expressed on Dendritic Cells is a New Receptor Implicated in Arenavirus Uptake

Proceedings, 2020
Arenaviruses are enveloped viruses that cause hemorrhagic fever outbreaks in humans and still lack an effective antiviral treatment. Upon early infection, these viruses target dendritic cells (DCs), which can promote systemic viral dissemination ...
Xabier Muniz-Trabudua, Cristina Borio, Marcos Bilen, Itziar Erkizia, Daniel Perez-Zsolt, Susana Benet, Javier Martinez-Picado, Nuria Izquierdo-Useros   +7 more
doaj   +1 more source

VelcroVax: a “Bolt-On” Vaccine Platform for Glycoprotein Display

mSphere, 2023
Having varied approaches to the design and manufacture of vaccines is critical in being able to respond to worldwide needs and newly emerging pathogens.
Natalie J. Kingston, Keith Grehan, Joseph S. Snowden, Mark Hassall, Jehad Alzahrani, Guido C. Paesen, Lee Sherry, Connor Hayward, Amy Roe, Sam Stephen, Darren Tomlinson, Antra Zeltina, Katie J. Doores, Neil A. Ranson, Martin Stacey, Mark Page, Nicola J. Rose, Thomas A. Bowden, David J. Rowlands, Nicola J. Stonehouse   +19 more
doaj   +1 more source

The Virus–Host Interplay in Junín Mammarenavirus Infection

Viruses, 2022
Junín virus (JUNV) belongs to the Arenaviridae family and is the causative agent of Argentine hemorrhagic fever (AHF), a severe human disease endemic to agricultural areas in Argentina.
Giovanna Lucrecia Gallo, Nora López, María Eugenia Loureiro   +2 more
doaj   +1 more source

Luminescent reporter cells enable the identification of broad‐spectrum antivirals against emerging viruses

Journal of Medical Virology, Volume 95, Issue 11, November 2023., 2023
Abstract The emerging viruses SARS‐CoV‐2 and arenaviruses cause severe respiratory and hemorrhagic diseases, respectively. The production of infectious particles of both viruses and virus spread in tissues requires cleavage of surface glycoproteins (GPs) by host proprotein convertases (PCs).
Karin Löw, Rebecca Möller, Cora Stegmann, Miriam Becker, Laura Rehburg, Helena Obernolte, Dirk Schaudien, Lisa Oestereich, Armin Braun, Stefan Kunz, Gisa Gerold   +10 more
wiley   +1 more source

The knowns and unknowns of cardiac autoimmunity in viral myocarditis

Reviews in Medical Virology, Volume 33, Issue 6, November 2023., 2023
Abstract Myocarditis can result from various infectious and non‐infectious causes that can lead to dilated cardiomyopathy (DCM) and heart failure. Among the infectious causes, viruses are commonly suspected. But the challenge is our inability to demonstrate infectious viral particles during clinical presentations, partly because by that point, the ...
Kiruthiga Mone, Jay Reddy
wiley   +1 more source

Surface layer proteins in species of the family Lactobacillaceae

Microbial Biotechnology, Volume 16, Issue 6, Page 1232-1249, June 2023., 2023
Manuscript is focus on the prediction of slp genes within the Lactobacillaceae family and interconnection between the two different modular SLP domain organizations of the new reclassified genera. SLP applications are reviewed regarding heterologous display, pathogen exclusion, immunostimulation, and metal binding. Abstract The S‐layer or surface layer
M. Mercedes Palomino, Mariana C. Allievi, Tania B. Gordillo, Sabrina S. Bockor, Joaquina Fina Martin, Sandra M. Ruzal   +5 more
wiley   +1 more source

Standardization of an ELISA test using a recombinant nucleoprotein from the Junin virus as the antigen and serological screening for arenavirus among the population of Nova Xavantina, State of Mato Grosso Padronização de um teste de ELISA utilizando a nucleoproteína recombinante de vírus Junin como antígeno e triagem sorológica para Arenavírus na população de Nova Xavantina, Estado do Mato Grosso

Revista da Sociedade Brasileira de Medicina Tropical, 2010
INTRODUCTION: Arenavirus hemorrhagic fever is a severe emerging disease. METHODS: Considering that the levels of antibodies against arenavirus in the Brazilian population are completely unknown, we have standardized an ELISA test for detecting IgG ...
Alex Martins Machado, Glauciane Garcia Figueiredo, Gelse Maria Campos, Mario Enrique Lozano, Aline Rafaela da Silva Rodrigues Machado, Luiz Tadeu Moraes Figueiredo   +5 more
doaj   +1 more source