A single mutation (V64G) within the RING Domain of Z attenuates Junin virus. [PDF]
PLoS Neglected Tropical Diseases, 2020 Junin virus (JUNV) is a New World arenavirus that is the causative agent of Argentine hemorrhagic fever (AHF). Candid#1 (Can) is a live-attenuated vaccine strain of JUNV that since its introduction has resulted in a marked decrease in AHF incidence ...
Steven J Hallam +7 more
doaj +2 more sources
Revista Peruana de Medicina Experimental y Salud Pública, 2015 The Argentine hemorrhagic fever (AHF) is a severe acute viral disease caused by the Junin virus of the Arenaviridae family. The AHF endemic area coincides geographically with the largest grain export agro-industrial complex of the country [Argentina ...
Ana Briggiler +6 more
doaj +3 more sources
A hTfR1 Receptor-Specific VHH Antibody Neutralizes Pseudoviruses Expressing Glycoproteins from Junín and Machupo Viruses [PDF]
VirusesThe Junín virus (JUNV) is one of the New World arenaviruses that cause severe hemorrhagic fever. Human transferrin receptor 1 (hTfR1) has been identified as the main receptor for JUNV for virus entry into host cells.
Qinglin Kang +13 more
doaj +2 more sources
Antigen vehiculization particles based on the Z protein of Junin virus [PDF]
BMC Biotechnology, 2012 Background Arenavirus matrix protein Z plays an important role in virus budding and is able to generate enveloped virus-like-particles (VLPs) in absence of any other viral proteins.
Borio Cristina S +6 more
doaj +2 more sources
Potent inhibition of Junín virus infection by interferon in murine cells. [PDF]
PLoS Neglected Tropical Diseases, 2014 The new world arenavirus Junín virus (JUNV) is the causative agent of Argentine hemorrhagic fever, a lethal human infectious disease. Adult laboratory mice are generally resistant to peripheral infection by JUNV.
Cheng Huang +6 more
doaj +2 more sources
RIG-I enhanced interferon independent apoptosis upon Junin virus infection. [PDF]
PLoS ONE, 2014 Junin virus (JUNV) is the etiological agent of Argentine hemorrhagic fever (AHF), a human disease with a high case-fatality rate. It is widely accepted that arenaviral infections, including JUNV infections, are generally non-cytopathic. In contrast, here
Olga A Kolokoltsova +10 more
doaj +2 more sources
Guinea Pig Transferrin Receptor 1 Mediates Cellular Entry of Junín Virus and Other Pathogenic New World Arenaviruses. [PDF]
J Virol, 2020 Hickerson BT +4 more
europepmc +3 more sources
Multi-epitope-based vaccine designing against Junín virus glycoprotein: immunoinformatics approach [PDF]
Future Journal of Pharmaceutical SciencesBackground The Junín virus (JUNV) is well known for causing argentine haemorrhagic fever (AHF), a severe endemic disease in farming premises. The glycoprotein of JUNV is an important therapeutic target in vaccine design.
Mallari Praveen
doaj +2 more sources
Development of horse neutralizing immunoglobulin and immunoglobulin fragments against Junín virus. [PDF]
Antiviral Res, 2020 Pan X, Wu Y, Wang W, Zhang L, Xiao G.
europepmc +2 more sources
Neutralization of Junín virus by single domain antibodies targeted against the nucleoprotein. [PDF]
Sci Rep, 2018 Linero F +5 more
europepmc +3 more sources