Results 141 to 150 of about 616,094 (331)

Multipoint Thermal Sensing System for Power Semiconductor Devices Utilizing Fiber Bragg Gratings

Applied Sciences
This study investigates the feasibility of using fiber Bragg grating (FBG) sensors for multipoint thermal monitoring of several power semiconductor devices (PSDs), such as insulated gate bipolar transistors (IGBTs), and rectifiers assembled on a common ...
Ridwanullahi Isa, Naveed Iqbal, Mohammad Abido, Jawad Mirza, Khurram Karim Qureshi   +4 more
doaj   +1 more source

Junction temperature of CMOS electronics cooled by a Stirling cryocooler

, 2023
Dmitry Smirnov, Federico Martin Ibanez, Henni Ouerdane   +2 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Drosophila Mutant with a Temperature-Sensitive Block in Nerve Conduction [PDF]

, 1978
A mutant, napts (no action potential, temperature-sensitive), is described in which axonal conduction fails at high temperature. Synaptic transmission at the larval neuromuscular junction is unimpaired.
Benzer, Seymour, Ganetzky, Barry, Jan, Lily Yeh, Jan, Yuh-Nung, Wu, Chun-Fang   +4 more
core  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Research of the tolerable pulsed power of silicon p+–p–n+-structure

Технологія та конструювання в електронній апаратурі, 2011
The conducted researches of the thermal parameters of the silicon p+–p–n+-structure under the influence of the pulse signal have shown that the structure thermal resistance decreases in proportion to the decrease in the thickness of the base region and ...
A. V. Karimov, D. M. Yodgorova, O. A. Abdulhaev, A. A. Karimov, G. O. Asanova   +4 more
doaj  

Low-temperature dissociative adsorption of Hydrogen on W, Mo and Ta surfaces studied with Mechanically Controllable Break-Junctions [PDF]

, 2007
Duncan den Boer, O. I. Shklyarevskiǐ, Johannes A. A. W. Elemans, S. Speller   +3 more
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Revisiting multi-domain empirical modelling of light-emitting diode luminaire

Cogent Engineering
In this work, an empirically derived multi-domain model of a light-emitting diode (LED) luminaire is proposed. The optical, electrical, and thermal characteristics of LEDs are obtained from the data sheets provided by manufacturers.
Shailesh K R, Tanuja Shailesh
doaj   +1 more source