Results 191 to 200 of about 3,166 (218)

Genetic Variation in Junin Virus

1993
Junin virus (JV) is a member of Arenaviridae able to cause a severe disease in humans known as Argentine hemorrhagic fever (AHF). The first isolation of this agent was performed in 1958 by Parodi et al. from a human case. Epidemics of AHF have occurred each year in the central area of the country, with incidence peaks coincident with harvest time of ...
Celia E. Coto, Elsa B. Damonte, Laura E. Alche, Luis Scolaro   +3 more
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An antibody for fighting Junin virus

C&EN Global Enterprise, 2016
Argentine hemorrhagic fever was discovered in the 1950s, and it hasn’t spread beyond Argentina’s borders since. But the illness’s mortality rate—which can be as high as 30%—has public health officials worried. The fever is caused by Junin virus and transmitted by rodents through their saliva and droppings, so it could spread outside its current range ...
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Involvement of vacuolar proton ATPase in Junin virus multiplication

Archives of Virology, 2001
The role of vacuolar-proton ATPase (V-H+ ATPAse) on Junin virus (JV) replication was evaluated by analyzing the effect of specific inhibitors of the enzyme activity on different steps of virus multiplication cycle. The presence of the macrolide antibiotics bafilomycin A1 and concanamycin A during the first two hours of infection caused a significant ...
V, Castilla, L M, Palermo, C E, Coto
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Calomys callidus as a potential junin virus reservoir

Journal of Medical Virology, 1989
AbstractThe present study investigated whether C. callidus, a species belonging to the Calomys genus, is capable of developing experimentally a persistent Junin virus (JV) infection. Newborn and adult cricetids were inoculated with the attenuated XJ‐Clone 3 strain of JV by intracerebral or mucosal route. The present results indicate that the species is
C, Videla, A, Kajon, G, Carballal, M, Weissenbacher   +3 more
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Junin virus access to CNS by extraneural rat inoculation

Journal of Medical Virology, 1986
AbstractThis study was carried out to determine the pathways along which two strains of Junin virus (JV), the pathogenic XJV and the attenuated XJC13V, reach the CNS following IP inoculation of 2‐day‐old rats. A sequential study of infectivity and antigen distribution in peritoneal macrophages, spleen, and brain was performed.
G D, Lerman, J L, Blejer, J R, Oubiña, G, Carballal, M R, Nejamkis   +4 more
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Ribavirin effect on experimental Junin virus‐induced encephalitis

Journal of Medical Virology, 1988
AbstractJunin virus, the etiological agent of Argentine hemorrhagic fever, produces in man a disease mainly characterized by hemorrhagic alterations, commonly accompanied by neurological symptoms, and leading to 10% mortality. Intracerebral inoculation in 10‐day‐old rats or intraperitoneal inoculation in 2‐day‐old rats leads to high mortality due to ...
M C, Remesar, J L, Blejer, M C, Weissenbacher, M R, Nejamkis   +3 more
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Experimental neuroinvasiveness of wild and laboratory junin virus strains

Research in Virology, 1992
The neuroinvasiveness of Candid 1 and XJCL3 laboratory strains and CbalV4454 and CbaFHA5069 wild strains of Junin virus was studied in albino mice, guinea pigs, and a South American wild rodent, Calomys musculinus (Cm), of different ages inoculated by a non-neural route. Infectivity in brain, blood and organs, as well as lethality, were determined. The
S I, Medeot, M S, Contigiani, M S, Sabattini, G, Diaz   +3 more
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Contrasuppressor cells induced by Junin virus.

Immunology, 1990
Intracerebral inoculation of Junin virus (JV) in all susceptible mouse models available induces a lethal meningoencephalitis compatible with a delayed-type hypersensitivity (DTH) immune response. In contrast, adult BALB/c mice prove resistant to infection and no DTH response is seen.
O E, Campetella, N V, Galassi, H A, Barrios   +2 more
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Photodynamic inactivation of Junin virus

Medical Microbiology and Immunology, 1986
M, Fernández Cobo, E L, Pasian, Z M, de Martínez Segovia   +2 more
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Tolerance to Junin virus in thymectomized mice

Archiv f�r die gesamte Virusforschung, 1967
G, Schmuñis, M, Weissenbacher, A S, Parodi   +2 more
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