Results 71 to 80 of about 1,189,304 (300)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Displacement as Significant Collateral Harm in War

open access: yesGlobal justice: Theory, Practice, Rhetoric, 2018
Traditionally, in deciding whether some strategy or action in war is proportionate and necessary and thus permissible both international law and just war theory focus exclusively on civilian deaths and the destruction of civilian infrastructure.
Jovana Davidovic
doaj   +1 more source

Unsatisfying Wars: Degrees of Risk and the \u3ci\u3eJus ex Bello\u3c/i\u3e [PDF]

open access: yes, 2014
Self-defensive war uses violence to transfer risks from one’s own people to others. We argue that central questions in just war theory may fruitfully be analyzed as issues about the morality of risk transfer.
Blum, Gabriella, Luban, David
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Prefaces and Postscripts: Walzer’s \u3cem\u3eJust and Unjust Wars\u3c/em\u3e at Age 40 [PDF]

open access: yes, 2017
This paper was written as a keynote address for a conference on Michael Walzer’s Just and Unjust War on the 40th anniversary of its publication. It discusses the significance of the book, and examines the updating prefaces Walzer wrote to the five ...
Luban, David
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Kořeny teorie spravedlivé války: od Platóna ke Grotiovi

open access: yesTheatrum Historiae, 2008
The so-called “just war theory” is one of the few instances in the history of human endeavors when organized violence (i.e. war) directly meets philosophy.
Jiří Hutečka
doaj  

Violence and Warfare

open access: yesمجلة الآداب
The Just War tradition (JWT) is viewed in this paper as a corpus of ideas that discusses the morality and ethics of war. It has changed throughout more than 1,500 years, making it a complicated one.
Bimbo OGUNBANJO
doaj   +1 more source

Public and private just wars: Distributed cyber deterrence based on Vitoria and Grotius

open access: yesInternet Policy Review, 2020
This contribution discusses the growing importance of cyber attacks directed at the public sphere and the crucial role of non-state actors in cyber attacks from a perspective of just war theory.
Johannes Thumfart
doaj   +1 more source

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